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UniProtKB/Swiss-Prot entry P08138


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TNR16_HUMAN
Primary accession number P08138
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on August 1, 1988 (Sequence version 1)
Annotations were last modified on    April 8, 2008 (Entry version 98)
Name and origin of the protein
Protein name Tumor necrosis factor receptor superfamily member 16 [Precursor]
Synonyms Low-affinity nerve growth factor receptor
NGF receptor
Gp80-LNGFR
p75 ICD
Low affinity neurotrophin receptor p75NTR
CD271 antigen
Gene name
Name: NGFR
Synonyms: TNFRSF16
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0092-8674(86)90619-7; PubMed=3022937 [NCBI, ExPASy, EBI, Israel, Japan]
Johnson D., Lanahan A., Buck C.R., Sehgal A., Morgan C., Mercer E., Bothwell M., Chao M.;
"Expression and structure of the human NGF receptor.";
Cell 47:545-554(1986).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
PubMed=2850481 [NCBI, ExPASy, EBI, Israel, Japan]
Sehgal A., Patil N., Chao M.;
"A constitutive promoter directs expression of the nerve growth factor receptor gene.";
Mol. Cell. Biol. 8:3160-3167(1988).
[4]
INTERACTION WITH TRAF2; TRAF4 AND TRAF6.
DOI=10.1074/jbc.274.42.30202; PubMed=10514511 [NCBI, ExPASy, EBI, Israel, Japan]
Ye X., Mehlen P., Rabizadeh S., VanArsdale T., Zhang H., Shin H., Wang J.J.L., Leo E., Zapata J.M., Hauser C.A., Reed J.C., Bredesen D.E.;
"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.";
J. Biol. Chem. 274:30202-30208(1999).
[5]
INTERACTION WITH TRAF6.
DOI=10.1074/jbc.274.5.2597; PubMed=9915784 [NCBI, ExPASy, EBI, Israel, Japan]
Khursigara G., Orlinick J.R., Chao M.V.;
"Association of the p75 neurotrophin receptor with TRAF6.";
J. Biol. Chem. 274:2597-2600(1999).
[6]
INTERACTION WITH PTPN13.
DOI=10.1016/S0014-5793(99)01324-1; PubMed=10544233 [NCBI, ExPASy, EBI, Israel, Japan]
Irie S., Hachiya T., Rabizadeh S., Maruyama W., Mukai J., Li Y., Reed J.C., Bredesen D.E., Sato T.A.;
"Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation.";
FEBS Lett. 460:191-198(1999).
[7]
INTERACTION WITH TRAF6 AND SQSTM1.
DOI=10.1074/jbc.C000869200; PubMed=11244088 [NCBI, ExPASy, EBI, Israel, Japan]
Wooten M.W., Seibenhener M.L., Mamidipudi V., Diaz-Meco M.T., Barker P.A., Moscat J.;
"The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.";
J. Biol. Chem. 276:7709-7712(2001).
[8]
INTERACTION WITH RANBP9.
TISSUE=Brain;
DOI=10.1016/j.bbrc.2003.08.033; PubMed=12963025 [NCBI, ExPASy, EBI, Israel, Japan]
Bai D., Chen H., Huang B.-R.;
"RanBPM is a novel binding protein for p75NTR.";
Biochem. Biophys. Res. Commun. 309:552-557(2003).
[9]
FUNCTION, AND INTERACTION WITH LINGO1.
DOI=10.1038/nn1188; PubMed=14966521 [NCBI, ExPASy, EBI, Israel, Japan]
Mi S., Lee X., Shao Z., Thill G., Ji B., Relton J., Levesque M., Allaire N., Perrin S., Sands B., Crowell T., Cate R.L., McCoy J.M., Pepinsky R.B.;
"LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.";
Nat. Neurosci. 7:221-228(2004).
[10]
STRUCTURE OF O-LINKED CARBOHYDRATE.
PubMed=8627329 [NCBI, ExPASy, EBI, Israel, Japan]
Chapman B.S., Eckart M.R., Kaufman S.E., Lapointe G.R.;
"O-linked oligosaccharide on the 75-kDa neurotrophin receptor.";
J. Neurochem. 66:1707-1716(1996).
Comments
  • FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
  • SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1.
  • SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
  • DOMAIN: Death domain is responsible for interaction with RANBP9.
  • DOMAIN: The extracellular domain is responsible for interaction with NTRK1 (By similarity).
  • PTM: N- and O-glycosylated.
  • PTM: O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
  • PTM: Phosphorylated on serine residues.
  • SIMILARITY: Contains 1 death domain.
  • SIMILARITY: Contains 4 TNFR-Cys repeats.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M14764; AAB59544.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC050309; AAH50309.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M21621; AAA36363.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A25218; GQHUN.
RefSeq NP_002498.1; -.
UniGene Hs.415768
3D structure databases
HSSP P07174; 1NGR. [HSSP ENTRY / PDB]
SMR P08138; 30-189, 333-420.
ModBase P08138.
Protein-protein interaction databases
DIP DIP:406N; -.
IntAct P08138; -.
PTM databases
GlycoSuiteDB P08138; -.
PhosphoSite P08138; -.
Organism-specific databases
H-InvDB HIX0027193; -.
HGNC HGNC:7809; NGFR.
GeneLynx NGFR; Homo sapiens.
GenAtlas NGFR.
HPA CAB000143; -.
CAB001995; -.
HPA004765; -.
MIM 162010; gene. [NCBI / EBI]
PharmGKB PA31615; -.
GeneCards P08138.
Gene expression databases
ArrayExpress P08138; -.
CleanEx HS_NGFR; -.
GermOnline ENSG00000064300; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004888; Molecular function: transmembrane receptor activity (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000488; Death.
IPR011029; DEATH_like.
IPR001368; TNFR_c6.
Graphical view of domain structure.
Gene3D G3DSA:1.10.533.10; DEATH_like; 1.
Pfam PF00531; Death; 1.
PF00020; TNFR_c6; 4.
Pfam graphical view of domain structure.
SMART SM00005; DEATH; 1.
SM00208; TNFR; 4.
SMART graphical view of domain structure.
PROSITE PS50017; DEATH_DOMAIN; 1.
PS00652; TNFR_NGFR_1; 3.
PS50050; TNFR_NGFR_2; 4.
PROSITE graphical view of domain structure (profiles).
BLOCKS P08138.
Proteomic databases
PeptideAtlas P08138; -.
Genome annotation databases
Ensembl ENSG00000064300; Homo sapiens. [Contig view]
GeneID 4804; -.
KEGG hsa:4804; -.
Other
SOURCE NGFR; Homo sapiens.
ProtoNet P08138.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Apoptosis; Developmental protein; Differentiation; Glycoprotein; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Receptor; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    28  28      
CHAIN   29   427  399     Tumor necrosis factor receptor superfamily member 16. PRO_0000034591
TOPO_DOM   29   250  222     Extracellular (Potential). 
TRANSMEM   251   272  22     Potential. 
TOPO_DOM   273   427  155     Cytoplasmic (Potential). 
REPEAT   31    64  34     TNFR-Cys 1. 
REPEAT   66   107  42     TNFR-Cys 2. 
REPEAT   108   146  39     TNFR-Cys 3. 
REPEAT   148   188  41     TNFR-Cys 4. 
DOMAIN   344   421  78     Death. 
REGION   326   341  16     Mediates interaction with ARMS (By similarity). 
COMPBIAS   197   248  52     Ser/Thr-rich. 
CARBOHYD   60    60        N-linked (GlcNAc...) (Probable) [GlycoSuiteDB]. CAR_000231
DISULFID   32    43        By similarity. 
DISULFID   44    57        By similarity. 
DISULFID   47    64        By similarity. 
DISULFID   67    83        By similarity. 
DISULFID   86    99        By similarity. 
DISULFID   89   107        By similarity. 
DISULFID   109   122        By similarity. 
DISULFID   125   138        By similarity. 
DISULFID   128   146        By similarity. 
DISULFID   149   164        By similarity. 
DISULFID   167   180        By similarity. 
DISULFID   170   188        By similarity. 
VARIANT   205   205  1     S -> L (in dbSNP:rs2072446 [NCBI]). VAR_020010 
Sequence information
Length: 427 AA [This is the length of the unprocessed precursor] Molecular weight: 45183 Da [This is the MW of the unprocessed precursor] CRC64: B09FA143FB3D625B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGAGATGRAM DGPRLLLLLL LGVSLGGAKE ACPTGLYTHS GECCKACNLG EGVAQPCGAN 

        70         80         90        100        110        120 
QTVCEPCLDS VTFSDVVSAT EPCKPCTECV GLQSMSAPCV EADDAVCRCA YGYYQDETTG 

       130        140        150        160        170        180 
RCEACRVCEA GSGLVFSCQD KQNTVCEECP DGTYSDEANH VDPCLPCTVC EDTERQLREC 

       190        200        210        220        230        240 
TRWADAECEE IPGRWITRST PPEGSDSTAP STQEPEAPPE QDLIASTVAG VVTTVMGSSQ 

       250        260        270        280        290        300 
PVVTRGTTDN LIPVYCSILA AVVVGLVAYI AFKRWNSCKQ NKQGANSRPV NQTPPPEGEK 

       310        320        330        340        350        360 
LHSDSGISVD SQSLHDQQPH TQTASGQALK GDGGLYSSLP PAKREEVEKL LNGSAGDTWR 

       370        380        390        400        410        420 
HLAGELGYQP EHIDSFTHEA CPVRALLASW ATQDSATLDA LLAALRRIQR ADLVESLCSE 


STATSPV 

P08138 in FASTA format

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