[1]
|
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Brain;
DOI=10.1016/0014-5793(94)00395-5; PubMed=8194594 [NCBI, ExPASy, EBI, Israel, Japan]
Jakes R.,
Spillantini M.G.,
Goedert M.;
"Identification of two distinct synucleins from human brain.";
FEBS Lett. 345:27-32(1994).
|
[2]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1998.5556; PubMed=9806846 [NCBI, ExPASy, EBI, Israel, Japan]
Lavedan C.,
Leroy E.,
Torres R.,
Dehejia A.,
Dutra A.,
Buchholtz S.,
Nussbaum R.L.,
Polymeropoulos M.H.;
"Genomic organization and expression of the human beta-synuclein gene (SNCB).";
Genomics 54:173-175(1998).
|
[3]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
|
[4]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L.,
Schick M.,
Neubert P.,
Schatten R.,
Henze S.,
Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
|
[5]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[6]
|
PROTEIN SEQUENCE OF 46-85, AND MASS SPECTROMETRY.
TISSUE=Fetal brain cortex;
Lubec G.,
Chen W.-Q.,
Sun Y.;
Submitted (DEC-2008) to UniProtKB.
|
[7]
|
PHOSPHORYLATION.
DOI=10.1074/jbc.M003542200; PubMed=10852916 [NCBI, ExPASy, EBI, Israel, Japan]
Pronin A.N.,
Morris A.J.,
Surguchov A.,
Benovic J.L.;
"Synucleins are a novel class of substrates for G protein-coupled receptor kinases.";
J. Biol. Chem. 275:26515-26522(2000).
|
|
- FUNCTION: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
- SUBCELLULAR LOCATION: Cytoplasm.
- TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
- PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
- DISEASE: Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
- SIMILARITY: Belongs to the synuclein family.
|
ExPASy Home page
CBR Canada
