[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Heart; DOI=10.1006/bbrc.1998.9876; PubMed=9920726 [NCBI, ExPASy, EBI, Israel, Japan] Nishimura Y., Hayashi M., Inada H., Tanaka T.; "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins."; Biochem. Biophys. Res. Commun. 254:21-26(1999).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[3]	PROTEIN SEQUENCE OF 176-182, AND MASS SPECTROMETRY. STRAIN=Sprague-Dawley; TISSUE=Brain; Lubec G., Kang S.U.; Submitted (JUL-2007) to UniProtKB.

Comments

FUNCTION: May play a role in vesicle trafficking.
SUBUNIT: Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type IV membrane protein (By similarity). Endomembrane system; Single-pass type IV membrane protein (By similarity). Note=Present in the plasma membrane and in intracellular vesicles (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Contains 1 MSP domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF086631; AAD13580.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC065576; AAH65576.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00209283; -.

NP_068619.1; -.

3D structure databases

SMR

Q9Z269; 1-134.

ModBase

Q9Z269.

Organism-specific databases

RGD

68326; Vapb.

Gene expression databases

ArrayExpress

Q9Z269; -.

GermOnline

ENSRNOG00000005331; Rattus norvegicus.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from sequence or structural similarity from UniProtKB).
GO:0005794;	Cellular component: Golgi apparatus (inferred from sequence or structural similarity from UniProtKB).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0048487;	Molecular function: beta-tubulin binding (inferred from sequence or structural similarity from UniProtKB).
GO:0019899;	Molecular function: enzyme binding (inferred from sequence or structural similarity from UniProtKB).
GO:0042803;	Molecular function: protein homodimerization activity (inferred from sequence or structural similarity from UniProtKB).
GO:0005198;	Molecular function: structural molecule activity (inferred from electronic annotation from InterPro).
GO:0030968;	Biological process: endoplasmic reticulum unfolded protein response (inferred from sequence or structural similarity from UniProtKB).
GO:0045070;	Biological process: positive regulation of viral genome replication (inferred from sequence or structural similarity from UniProtKB).
GO:0019048;	Biological process: virus-host interaction (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR000535; Major_sperm.
IPR008962; PapD-like.
IPR016763; Vesicle-associated_membrane.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.360; MSP; 1.

Pfam

PF00635; Motile_Sperm; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF019693; VAMP-associated; 1.

PROSITE

PS50202; MSP; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9Z269; -.

Genome annotation databases

Ensembl

ENSRNOG00000005331; Rattus norvegicus. [Contig view]

GeneID

60431; -.

KEGG

rno:60431; -.

Phylogenomic databases

HOVERGEN

Q9Z269; -.

OMA

Q9Z269; KTAQSNS.

Other

612154; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Coiled coil; Direct protein sequencing; Membrane; Phosphoprotein; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 243`	`242`	`Vesicle-associated membrane protein-associated protein B.`	`PRO_0000213475`
`TOPO_DOM`	`2 218`	`217`	`Cytoplasmic (Potential).`
`TRANSMEM`	`219 239`	`21`	`Anchor for type IV membrane protein (Potential).`
`DOMAIN`	`7 124`	`118`	`MSP.`
`COILED`	`161 196`	`36`	`Potential.`
`MOD_RES`	`159 159`		`Phosphoserine (By similarity).`
`MOD_RES`	`206 206`		`Phosphoserine (By similarity).`

Sequence information

Length: 243 AA [This is the length of the unprocessed precursor]

Molecular weight: 26916 Da [This is the MW of the unprocessed precursor]

CRC64: 870B177B0798B4EA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGV 

        70         80         90        100        110        120 
IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS DMEAVWKEAK PEDLMDSKLR 

       130        140        150        160        170        180 
CVFELPAENA KPHDVEINKI MPTSASKTEA PVAAKPLTSP LDDAEVKKVM EECRRLQGEV 

       190        200        210        220        230        240 
QRLREESRQL KEEDGLRARK ALPSNSPMAA LAASGKEEGL SARLLALVVL FFIVGVIIGK 


IAL

Q9Z269 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools