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UniProtKB/Swiss-Prot entry Q9YA15


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GCSPA_AERPE
Primary accession number Q9YA15
Secondary accession numbers None
Integrated into Swiss-Prot on October 3, 2003
Sequence was last modified on July 10, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 36)
Name and origin of the protein
Protein name Probable glycine dehydrogenase [decarboxylating] subunit 1
Synonyms EC 1.4.4.2
Glycine decarboxylase subunit 1
Glycine cleavage system P-protein subunit 1
Gene name
Name: gcvPA
OrderedLocusNames: APE_2124.1
From
Aeropyrum pernix [TaxID: 56636] [HAMAP proteome]
Taxonomy Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Desulfurococcaceae; Aeropyrum.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K1;
DOI=10.1093/dnares/6.2.83; PubMed=10382966 [NCBI, ExPASy, EBI, Israel, Japan]
Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1.";
DNA Res. 6:83-101(1999).
Comments
  • FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).
  • CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2.
  • SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits (By similarity).
  • SIMILARITY: Belongs to the gcvP family. N-terminal subunit subfamily.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000002; BAA81135.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G72518; G72518.
RefSeq NP_148401.2; -.
3D structure databases
ModBase Q9YA15.
Ontologies
GO
GO:0004375; Molecular function: glycine dehydrogenase (decarboxylating) activity (inferred from electronic annotation from InterPro).
GO:0030170; Molecular function: pyridoxal phosphate binding (inferred from electronic annotation from InterPro).
GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00712; -; 1.
PBIL [Tree]
InterPro IPR003437; GDC-P.
IPR015421; PyrdxlP-dep_Trfase_major_sub1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
PANTHER PTHR11773; GDC-P; 1.
Pfam PF02347; GDC-P; 1.
Pfam graphical view of domain structure.
ProtoNet Q9YA15.
Genome annotation databases
GeneID 1445209; -.
GenomeReviews BA000002_GR; APE_2124.1.
KEGG ape:APE_2124.1; -.
NMPDR fig|272557.1.peg.1509; -.
Phylogenomic databases
HOGENOM Q9YA15; -.
Genome annotation databases
CMR Q9YA15; APE_2124.1.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   465  465     Probable glycine dehydrogenase [decarboxylating] subunit 1. PRO_0000166982
Sequence information
Length: 465 AA [This is the length of the unprocessed precursor] Molecular weight: 51103 Da [This is the MW of the unprocessed precursor] CRC64: 922E4FEC815313F8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEHPWIPNSH KAILDEMLEA IGVSSVDDLY RDIPPTILLS PEEWDSLPIG EGRPLSEAEV 

        70         80         90        100        110        120 
LARINDILSR NKYFTDPPPF VGGGVWPRYV PSVVKALITR GEFLTAYTPY QAEISQGLMQ 

       130        140        150        160        170        180 
ALFEYQSLVA ELLEMEVVNA SLYDWSSAVG EAMLMARRVT RRNRVLVPET MNPLHLETAT 

       190        200        210        220        230        240 
TYAYGGGIRV EKVRVDRETG FIDLEDLESR LSQGDTAALY MEYPSSYTGV IDENVEAAGE 

       250        260        270        280        290        300 
AVHKAGGLFI LGVEPVSMAI LKPPGRLGAD IAVGDGQPLG LGLNYGGPYL GVFAVRWDGR 

       310        320        330        340        350        360 
LVRQMPGRLI GMTVDAEGRR AFAMILQTRE QHIRRAKATS NITTNEALMA IAAAVYLSLL 

       370        380        390        400        410        420 
GPQGLREVAE ASWYMSHYAA KRLSELRGVE APLLEGEFIM DFTVRLPMDA GVARRRLLEK 

       430        440        450        460 
GVLAGIPLGG FSFFSDNDML LTVTEAHTRR HVDLLVNLLD SVLGG 

Q9YA15 in FASTA format

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