[1]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ARG-100.
Koch-Nolte F.;
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ARG-100.
TISSUE=Fetal brain;
DOI=10.1006/geno.1999.5799; PubMed=10329013 [NCBI, ExPASy, EBI, Israel, Japan]
Johansson M.;
"A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues.";
Genomics 57:442-445(1999).
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ARG-100, AND SUBCELLULAR LOCATION.
TISSUE=Frontal cortex;
DOI=10.1242/jcs.00341; PubMed=12640039 [NCBI, ExPASy, EBI, Israel, Japan]
Augustin A.,
Spenlehauer C.,
Dumond H.,
Menissier-de Murcia J.,
Piel M.,
Schmit A.-C.,
Apiou F.,
Vonesch J.-L.,
Kock M.,
Bornens M.,
de Murcia G.M.;
"PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.";
J. Cell Sci. 116:1551-1562(2003).
|
[4]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04728; PubMed=16641997 [NCBI, ExPASy, EBI, Israel, Japan]
Muzny D.M.,
Scherer S.E.,
Kaul R.,
Wang J.,
Yu J.,
Sudbrak R.,
Buhay C.J.,
Chen R.,
Cree A.,
Ding Y.,
Dugan-Rocha S.,
Gill R.,
Gunaratne P.,
Harris R.A.,
Hawes A.C.,
Hernandez J.,
Hodgson A.V.,
Hume J.,
Jackson A., ![]()
Khan Z.M.,
Kovar-Smith C.,
Lewis L.R.,
Lozado R.J.,
Metzker M.L.,
Milosavljevic A.,
Miner G.R.,
Morgan M.B.,
Nazareth L.V.,
Scott G.,
Sodergren E.,
Song X.-Z.,
Steffen D.,
Wei S.,
Wheeler D.A.,
Wright M.W.,
Worley K.C.,
Yuan Y.,
Zhang Z.,
Adams C.Q.,
Ansari-Lari M.A.,
Ayele M.,
Brown M.J.,
Chen G.,
Chen Z.,
Clendenning J.,
Clerc-Blankenburg K.P.,
Chen R.,
Chen Z.,
Davis C.,
Delgado O.,
Dinh H.H.,
Dong W.,
Draper H.,
Ernst S.,
Fu G.,
Gonzalez-Garay M.L.,
Garcia D.K.,
Gillett W.,
Gu J.,
Hao B.,
Haugen E.,
Havlak P.,
He X.,
Hennig S.,
Hu S.,
Huang W.,
Jackson L.R.,
Jacob L.S.,
Kelly S.H.,
Kube M.,
Levy R.,
Li Z.,
Liu B.,
Liu J.,
Liu W.,
Lu J.,
Maheshwari M.,
Nguyen B.-V.,
Okwuonu G.O.,
Palmeiri A.,
Pasternak S.,
Perez L.M.,
Phelps K.A.,
Plopper F.J.,
Qiang B.,
Raymond C.,
Rodriguez R.,
Saenphimmachak C.,
Santibanez J.,
Shen H.,
Shen Y.,
Subramanian S.,
Tabor P.E.,
Verduzco D.,
Waldron L.,
Wang J.,
Wang J.,
Wang Q.,
Williams G.A.,
Wong G.K.-S.,
Yao Z.,
Zhang J.,
Zhang X.,
Zhao G.,
Zhou J.,
Zhou Y.,
Nelson D.,
Lehrach H.,
Reinhardt R.,
Naylor S.L.,
Yang H.,
Olson M.,
Weinstock G.,
Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
|
[5]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-100.
TISSUE=B-cell;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[6]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-533 (ISOFORM 1), AND VARIANT ARG-100.
TISSUE=Kidney;
DOI=10.1186/1471-2164-8-399; PubMed=17974005 [NCBI, ExPASy, EBI, Israel, Japan]
Bechtel S.,
Rosenfelder H.,
Duda A.,
Schmidt C.P.,
Ernst U.,
Wellenreuther R.,
Mehrle A.,
Schuster C.,
Bahr A.,
Blocker H.,
Heubner D.,
Hoerlein A.,
Michel G.,
Wedler H.,
Kohrer K.,
Ottenwalder B.,
Poustka A.,
Wiemann S.,
Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
|
[7]
|
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH PRKDC; PARP1; EZH2; HDAC1; HDAC2; SUZ12; YY1; LIG3 AND LIG4.
DOI=10.1002/jcb.21051; PubMed=16924674 [NCBI, ExPASy, EBI, Israel, Japan]
Rouleau M.,
McDonald D.,
Gagne P.,
Ouellet M.E.,
Droit A.,
Hunter J.M.,
Dutertre S.,
Prigent C.,
Hendzel M.J.,
Poirier G.G.;
"PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.";
J. Cell. Biochem. 100:385-401(2007).
|
[8]
|
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 178-532 IN COMPLEX WITH THE INHIBITOR 3-AMINOBENZOIC ACID.
Structural genomics consortium (SGC);
"Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid.";
Submitted (APR-2007) to the PDB data bank.
|
[9]
|
STRUCTURE BY NMR OF 41-157.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3.";
Submitted (APR-2008) to the PDB data bank.
|
|
- FUNCTION: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
- CATALYTIC ACTIVITY: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
- SUBUNIT: Interacts with PRKDC and PARP1. Interacts with XRCC5; the interaction is dependent on nucleic acids. Interacts with XRCC6; the interaction is dependent on nucleic acids. Interacts with EZH2, HDAC1, HDAC2, SUZ12, YY1, LIG3 and LIG4.
- INTERACTION:
Q16778:HIST2H2BE; NbExp=1; IntAct=EBI-1045281, EBI-1056125;
Q71DI3:HIST2H3A; NbExp=1; IntAct=EBI-1045281, EBI-750650;
- SUBCELLULAR LOCATION: Nucleus. Centrosome. Centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According PubMed:16924674 is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
| Name | 1 |
| Synonyms | Short |
| Isoform ID | Q9Y6F1-1 |
| Note: More abundant according to PubMed:16924674. |
| This is the isoform sequence displayed in this entry. |
|
|
| Name | 2 |
| Synonyms | Long |
| Isoform ID | Q9Y6F1-2 |
| Features which should be applied to build the isoform sequence: VSP_007863. |
|
|
- TISSUE SPECIFICITY: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
- DOMAIN: According to PubMed:10329013 the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain.
- PTM: Auto-poly(ADP)-ribosylation.
- SIMILARITY: Contains 1 PARP alpha-helical domain.
- SIMILARITY: Contains 1 PARP catalytic domain.
|
ExPASy Home page
CBR Canada
