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UniProtKB/Swiss-Prot entry Q9Y679


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AUP1_HUMAN
Primary accession number Q9Y679
Secondary accession numbers Q9H866 Q9UNQ6 Q9Y685
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    April 14, 2009 (Entry version 69)
Name and origin of the protein
Protein name Ancient ubiquitous protein 1
Synonyms None
Gene name
Name: AUP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
TISSUE=Pituitary;
Peng Y., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.;
"Human ancient ubiquitous protein AUP1 isoform gene.";
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
TISSUE=Umbilical cord blood;
DOI=10.1101/gr.140200; PubMed=11042152 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.";
Genome Res. 10:1546-1560(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
TISSUE=Hematopoietic stem cell;
Gu J., Huang Q., Yu Y., Xu S., Han Z., Fu G., Zhou J., Wang Y., Huang C., Ren S., Tu Y., Chen Z.;
"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients.";
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
TISSUE=Eye;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
TISSUE=Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
SUBCELLULAR LOCATION, INTERACTION WITH ITGA2B; ITGA1; ITGA2; ITGA5; ITGAV AND ITGAM, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.M204340200; PubMed=12042322 [NCBI, ExPASy, EBI, Israel, Japan]
Kato A., Kawamata N., Tamayose K., Egashira M., Miura R., Fujimura T., Murayama K., Oshimi K.;
"Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.";
J. Biol. Chem. 277:28934-28941(2002).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354; SER-358; SER-422; SER-429 AND THR-433, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[8]
IDENTIFICATION IN A COMPLEX WITH SEL1L, SUBCELLULAR LOCATION, AND FUNCTION.
DOI=10.1073/pnas.0805371105; PubMed=18711132 [NCBI, ExPASy, EBI, Israel, Japan]
Mueller B., Klemm E.J., Spooner E., Claessen J.H., Ploegh H.L.;
"SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 105:12325-12330(2008).
[9]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[10]
STRUCTURE BY NMR OF 358-411.
RIKEN structural genomics initiative (RSGI);
"Solution structure of RUH-075, a human CUE domain.";
Submitted (SEP-2007) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF100754; AAD43018.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF100753; AAD43017.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF100746; AAD43010.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF165515; AAF86645.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK023983; BAB14753.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033646; AAH33646.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00001891; -.
IPI00215815; -.
IPI00917463; -.
UniGene Hs.411480
3D structure databases
PDB
2EKF; NMR; -; A=358-411.[ExPASy / RCSB / EBI]
PDBsum 2EKF; -.
ModBase Q9Y679.
Protein-protein interaction databases
IntAct Q9Y679; 7.
PTM databases
PhosphoSite Q9Y679; -.
Organism-specific databases
GeneCards GC02M074607; -.
HGNC HGNC:891; AUP1.
GenAtlas AUP1.
HPA HPA007674; -.
MIM 602434; gene. [NCBI / EBI]
PharmGKB PA25182; -.
Gene expression databases
ArrayExpress Q9Y679; -.
Bgee Q9Y679; -.
CleanEx HS_AUP1; -.
GermOnline ENSG00000115307; Homo sapiens.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005634; Cellular component: nucleus (inferred from direct assay from HPA).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0019941; Biological process: modification-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR003892; CUE.
Graphical view of domain structure.
Pfam PF02845; CUE; 1.
Pfam graphical view of domain structure.
SMART SM00546; CUE; 1.
SMART graphical view of domain structure.
PROSITE PS51140; CUE; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9Y679; -.
Genome annotation databases
Ensembl ENSG00000115307; Homo sapiens. [Contig view]
Phylogenomic databases
HOGENOM Q9Y679; -.
HOVERGEN Q9Y679; -.
Other
SOURCE AUP1; Homo sapiens.
ProtoNet Q9Y679.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Endoplasmic reticulum; Membrane; Phosphoprotein; Transmembrane; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   476  476     Ancient ubiquitous protein 1. PRO_0000020765
TOPO_DOM   1    20  20     Lumenal (Potential). 
TRANSMEM   21    41  21     Signal-anchor for type III membrane protein (Potential). 
TOPO_DOM   42   476  435     Cytoplasmic (Potential). 
DOMAIN   362   404  43     CUE. 
COMPBIAS   160   165  6     Poly-Phe. 
MOD_RES   354   354        Phosphoserine. 
MOD_RES   358   358        Phosphoserine. 
MOD_RES   422   422        Phosphoserine. 
MOD_RES   429   429        Phosphoserine. 
MOD_RES   433   433        Phosphothreonine. 
VAR_SEQ   114   179        Missing (in isoform Short and isoform 3). VSP_004133
VAR_SEQ   426   439        FPSSGPVTPQPTAL -> AFDACLMMMTPQAL (in isoform 3). VSP_036228
VAR_SEQ   440   476        Missing (in isoform 3). VSP_036229
CONFLICT   354   354        S -> P (in Ref. 3; AAD43010). 
HELIX   363   373  11      
STRAND   375   377  3      
HELIX   379   387  9      
HELIX   392   400  9      
Sequence information
Length: 476 AA [This is the length of the unprocessed precursor] Molecular weight: 53028 Da [This is the MW of the unprocessed precursor] CRC64: A6AF3AAD84AE86CB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MELPSGPGPE RLFDSHRLPG DCFLLLVLLL YAPVGFCLLV LRLFLGIHVF LVSCALPDSV 

        70         80         90        100        110        120 
LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF DHNIVNLLTT CSTVSESEAE 

       130        140        150        160        170        180 
SATGRFPGAQ LKAPLSPLAF RMEDTEALPL TPILYPTCQF FFFIFLNIFL LAFSSPGSQP 

       190        200        210        220        230        240 
LLNSPPSFVC WSRGFMEMNG RGELVESLKR FCASTRLPPT PLLLFPEEEA TNGREGLLRF 

       250        260        270        280        290        300 
SSWPFSIQDV VQPLTLQVQR PLVSVTVSDA SWVSELLWSL FVPFTVYQVR WLRPVHRQLG 

       310        320        330        340        350        360 
EANEEFALRV QQLVAKELGQ TGTRLTPADK AEHMKRQRHP RLRPQSAQSS FPPSPGPSPD 

       370        380        390        400        410        420 
VQLATLAQRV KEVLPHVPLG VIQRDLAKTG CVDLTITNLL EGAVAFMPED ITKGTQSLPT 

       430        440        450        460        470 
ASASKFPSSG PVTPQPTALT FAKSSWARQE SLQERKQALY EYARRRFTER RAQEAD 

Q9Y679 in FASTA format

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