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UniProtKB/Swiss-Prot entry Q9Y5S1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TRPV2_HUMAN
Primary accession number Q9Y5S1
Secondary accession numbers A6NML2 A8K0Z0 Q9Y670
Integrated into Swiss-Prot on April 26, 2005
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 70)
Name and origin of the protein
Protein name Transient receptor potential cation channel subfamily V member 2
Synonyms TrpV2
Osm-9-like TRP channel 2
OTRPC2
Vanilloid receptor-like protein 1
VRL-1
Gene name
Name: TRPV2
Synonyms: VRL
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
TISSUE=Lymphoblast;
DOI=10.1038/18906; PubMed=10201375 [NCBI, ExPASy, EBI, Israel, Japan]
Caterina M.J., Rosen T.A., Tominaga M., Brake A.J., Julius D.;
"A capsaicin-receptor homologue with a high threshold for noxious heat.";
Nature 398:436-441(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymphoblast;
Garcia R.L., Delmas P., Cesare P., England S., Liapi A., Wood J.N.;
"Cloning and functional expression of VRL, a vanilloid receptor-like gene.";
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Kelsell R.E.;
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04689; PubMed=16625196 [NCBI, ExPASy, EBI, Israel, Japan]
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.";
Nature 440:1045-1049(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1021/pr060363j; PubMed=17081065 [NCBI, ExPASy, EBI, Israel, Japan]
Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F.;
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.";
J. Proteome Res. 5:3135-3144(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-523 AND SER-524, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
[10]
X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 69-319, AND DOMAINS ANKYRIN REPEATS.
DOI=10.1110/ps.062357206; PubMed=16882997 [NCBI, ExPASy, EBI, Israel, Japan]
McCleverty C.J., Koesema E., Patapoutian A., Lesley S.A., Kreusch A.;
"Crystal structure of the human TRPV2 channel ankyrin repeat domain.";
Protein Sci. 15:2201-2206(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF129112; AAD26363.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF103906; AAD41724.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ487963; CAD32310.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK289705; BAF82394.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC093484; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
CH471222; EAX04508.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC018926; AAH18926.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051305; AAH51305.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00183666; -.
RefSeq NP_057197.2; -.
UniGene Hs.279746
3D structure databases
PDB
2F37; X-ray; 1.70 A; A/B=69-319.[ExPASy / RCSB / EBI]
PDBsum 2F37; -.
ModBase Q9Y5S1.
Protein family/group databases
TCDB 1.A.4.2.8; transient receptor potential Ca2+ channel (TRP-CC) family.
PTM databases
PhosphoSite Q9Y5S1; -.
Organism-specific databases
GeneCards GC17P016259; -.
H-InvDB HIX0013570; -.
HIX0059753; -.
HGNC HGNC:18082; TRPV2.
GenAtlas TRPV2.
MIM 606676; gene. [NCBI / EBI]
PharmGKB PA38292; -.
Gene expression databases
ArrayExpress Q9Y5S1; -.
Bgee Q9Y5S1; -.
CleanEx HS_TRPV2; -.
GermOnline ENSG00000187688; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0042470; Cellular component: melanosome (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005262; Molecular function: calcium channel activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006816; Biological process: calcium ion transport (inferred from electronic annotation from UniProtKB-KW).
GO:0009266; Biological process: response to temperature stimulus (inferred from direct assay from MGI).
GO:0007600; Biological process: sensory perception (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002110; ANK.
IPR005821; Ion_trans.
IPR004729; TRP_channel.
IPR008347; Vanilpoid_rcpt.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.20; ANK; 1.
Pfam PF00023; Ank; 4.
PF00520; Ion_trans; 1.
Pfam graphical view of domain structure.
PRINTS PR01768; TRPVRECEPTOR.
SMART SM00248; ANK; 4.
SMART graphical view of domain structure.
TIGRFAMs TIGR00870; trp; 1.
PROSITE PS50297; ANK_REP_REGION; 1.
PS50088; ANK_REPEAT; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9Y5S1; -.
Genome annotation databases
Ensembl ENSG00000187688; Homo sapiens. [Contig view]
GeneID 51393; -.
KEGG hsa:51393; -.
Phylogenomic databases
HOVERGEN Q9Y5S1; -.
OMA Q9Y5S1; LWYFWRR.
Other
NextBio 54925; -.
SOURCE TRPV2; Homo sapiens.
ProtoNet Q9Y5S1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ANK repeat; Calcium; Calcium channel; Calcium transport; Cell membrane; Cytoplasm; Glycoprotein; Ion transport; Ionic channel; Membrane; Phosphoprotein; Polymorphism; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   764  764     Transient receptor potential cation channel subfamily V member 2. PRO_0000215342
TOPO_DOM   1   390  390     Cytoplasmic (Potential). 
TRANSMEM   391   411  21     Potential. 
TOPO_DOM   412   434  23     Extracellular (Potential). 
TRANSMEM   435   455  21     Potential. 
TOPO_DOM   456   471  16     Cytoplasmic (Potential). 
TRANSMEM   472   492  21     Potential. 
TOPO_DOM   493   493  1     Extracellular (Potential). 
TRANSMEM   494   514  21     Potential. 
TOPO_DOM   515   537  23     Cytoplasmic (Potential). 
TRANSMEM   538   558  21     Potential. 
TOPO_DOM   559   621  63     Pore forming (Potential). 
TRANSMEM   622   642  21     Potential. 
TOPO_DOM   643   764  122     Cytoplasmic (Potential). 
REPEAT   72   114  43     ANK 1. 
REPEAT   115   161  47     ANK 2. 
REPEAT   162   207  46     ANK 3. 
REPEAT   208   243  36     ANK 4. 
REPEAT   244   292  49     ANK 5. 
REPEAT   293   319  27     ANK 6. 
MOD_RES   523   523        Phosphotyrosine. 
MOD_RES   524   524        Phosphoserine. 
CARBOHYD   570   570        N-linked (GlcNAc...) (Potential). 
VARIANT   17    17  1     G -> A (in dbSNP:rs3813768 [NCBI]). VAR_024678 
CONFLICT   52    52        P -> S (in Ref. 2; AAD41724). 
CONFLICT   82    82        A -> V (in Ref. 2; AAD41724). 
CONFLICT   200   200        K -> N (in Ref. 2; AAD41724). 
CONFLICT   459   459        V -> L (in Ref. 2; AAD41724). 
CONFLICT   465   466        FI -> YT (in Ref. 2; AAD41724). 
CONFLICT   477   478        QA -> HS (in Ref. 2; AAD41724). 
CONFLICT   485   485        Q -> L (in Ref. 2; AAD41724). 
CONFLICT   491   491        A -> V (in Ref. 2; AAD41724). 
CONFLICT   535   536        LL -> MV (in Ref. 2; AAD41724). 
CONFLICT   540   540        L -> V (in Ref. 2; AAD41724). 
HELIX   76    84  9      
HELIX   88    91  4      
HELIX   94   101  8      
HELIX   108   110  3      
TURN   113   115  3      
HELIX   119   125  7      
HELIX   135   145  11      
HELIX   151   153  3      
TURN   159   163  5      
HELIX   166   172  7      
HELIX   176   184  9      
HELIX   196   198  3      
HELIX   212   218  7      
HELIX   222   230  9      
HELIX   248   255  8      
HELIX   260   280  21      
HELIX   286   288  3      
HELIX   297   303  7      
HELIX   307   315  9      
Sequence information
Length: 764 AA [This is the length of the unprocessed precursor] Molecular weight: 85981 Da [This is the MW of the unprocessed precursor] CRC64: A73E3696E70F91E9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTSPSSSPVF RLETLDGGQE DGSEADRGKL DFGSGLPPME SQFQGEDRKF APQIRVNLNY 

        70         80         90        100        110        120 
RKGTGASQPD PNRFDRDRLF NAVSRGVPED LAGLPEYLSK TSKYLTDSEY TEGSTGKTCL 

       130        140        150        160        170        180 
MKAVLNLKDG VNACILPLLQ IDRDSGNPQP LVNAQCTDDY YRGHSALHIA IEKRSLQCVK 

       190        200        210        220        230        240 
LLVENGANVH ARACGRFFQK GQGTCFYFGE LPLSLAACTK QWDVVSYLLE NPHQPASLQA 

       250        260        270        280        290        300 
TDSQGNTVLH ALVMISDNSA ENIALVTSMY DGLLQAGARL CPTVQLEDIR NLQDLTPLKL 

       310        320        330        340        350        360 
AAKEGKIEIF RHILQREFSG LSHLSRKFTE WCYGPVRVSL YDLASVDSCE ENSVLEIIAF 

       370        380        390        400        410        420 
HCKSPHRHRM VVLEPLNKLL QAKWDLLIPK FFLNFLCNLI YMFIFTAVAY HQPTLKKQAA 

       430        440        450        460        470        480 
PHLKAEVGNS MLLTGHILIL LGGIYLLVGQ LWYFWRRHVF IWISFIDSYF EILFLFQALL 

       490        500        510        520        530        540 
TVVSQVLCFL AIEWYLPLLV SALVLGWLNL LYYTRGFQHT GIYSVMIQKV ILRDLLRFLL 

       550        560        570        580        590        600 
IYLVFLFGFA VALVSLSQEA WRPEAPTGPN ATESVQPMEG QEDEGNGAQY RGILEASLEL 

       610        620        630        640        650        660 
FKFTIGMGEL AFQEQLHFRG MVLLLLLAYV LLTYILLLNM LIALMSETVN SVATDSWSIW 

       670        680        690        700        710        720 
KLQKAISVLE MENGYWWCRK KQRAGVMLTV GTKPDGSPDE RWCFRVEEVN WASWEQTLPT 

       730        740        750        760 
LCEDPSGAGV PRTLENPVLA SPPKEDEDGA SEENYVPVQL LQSN 

Q9Y5S1 in FASTA format

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