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UniProtKB/Swiss-Prot entry Q9Y315

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DEOC_HUMAN
Primary accession number Q9Y315
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 2002
Sequence was last modified on November 1, 2002 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name Putative deoxyribose-phosphate aldolase
Synonyms EC 4.1.2.4
Phosphodeoxyriboaldolase
Deoxyriboaldolase
DERA
Gene name
Name: DERA
ORFNames: CGI-26
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.10.5.703; PubMed=10810093 [NCBI, ExPASy, EBI, Israel, Japan]
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.";
Genome Res. 10:703-713(2000).
[2]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF132960; AAD27735.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_057038.2; -.
UniGene Hs.39429
3D structure databases
HSSP P00882; 1JCL. [HSSP ENTRY / PDB]
ModBase Q9Y315.
Protein-protein interaction databases
IntAct Q9Y315; -.
PTM databases
PhosphoSite Q9Y315; -.
Organism-specific databases
HGNC HGNC:24269; DERA.
GenAtlas DERA.
PharmGKB PA134943367; -.
GeneCards Q9Y315.
Gene expression databases
ArrayExpress Q9Y315; -.
CleanEx HS_DERA; -.
GermOnline ENSG00000023697; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0004139; Molecular function: deoxyribose-phosphate aldolase activity (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0009264; Biological process: deoxyribonucleotide catabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR011343; DeoC.
IPR002915; DeoC/AroFGH_arch.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
PANTHER PTHR10889; DeoC; 1.
Pfam PF01791; DeoC; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001357; DeoC; 1.
TIGRFAMs TIGR00126; deoC; 1.
ProtoNet Q9Y315.
Genome annotation databases
Ensembl ENSG00000023697; Homo sapiens. [Contig view]
GeneID 51071; -.
KEGG hsa:51071; -.
NMPDR fig|9606.3.peg.7251; -.
Phylogenomic databases
HOVERGEN Q9Y315; -.
Other
NextBio 53683; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Lyase; Phosphoprotein; Schiff base.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   318  318     Putative deoxyribose-phosphate aldolase. PRO_0000057310
ACT_SITE   218   218        Schiff-base intermediate with acetaldehyde (By similarity). 
ACT_SITE   254   254        By similarity. 
MOD_RES   261   261        Phosphoserine. 
Sequence information
Length: 318 AA [This is the length of the unprocessed precursor] Molecular weight: 35231 Da [This is the MW of the unprocessed precursor] CRC64: E9576567D0E5CBDE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS 

        70         80         90        100        110        120 
GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI 

       130        140        150        160        170        180 
PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEA LYDEIRQFRK 

       190        200        210        220        230        240 
ACGEAHLKTI LATGELGTLT NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI 

       250        260        270        280        290        300 
RDFFWKTGNK IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ 

       310 
IYHHVTGRYA AYHDLPMS
Q9Y315 in FASTA format

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