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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1006/geno.1999.6053; PubMed=10673335 [NCBI, ExPASy, EBI, Israel, Japan]
Suzuki T.,
Nishiyama K.,
Yamamoto A.,
Inazawa J.,
Iwaki T.,
Yamada T.,
Kanazawa I.,
Sakaki Y.;
"Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.";
Genomics 63:246-254(2000).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1093/dnares/5.1.31; PubMed=9628581 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T.,
Ishikawa K.,
Miyajima N.,
Tanaka A.,
Kotani H.,
Nomura N.,
Ohara O.;
"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.";
DNA Res. 5:31-39(1998).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Is part of lamellipodial complex that controls Rac-dependent actin remodeling (By similarity).
- SUBUNIT: Associates preferentially with the first SH3 domain of NCK. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Also a component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity).
- INTERACTION:
Q8IZP0:ABI1; NbExp=2; IntAct=EBI-389845, EBI-375446;
Q7L576:CYFIP1; NbExp=2; IntAct=EBI-389845, EBI-1048143;
P31946:YWHAB; NbExp=1; IntAct=EBI-389845, EBI-359815;
P63104:YWHAZ; NbExp=1; IntAct=EBI-389845, EBI-347088;
- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=At the interface between the lamellipodial actin meshwork and the membrane (By similarity).
- TISSUE SPECIFICITY: Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.
- SIMILARITY: Belongs to the HEM-1/HEM-2 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1128 AA [This is the length of the unprocessed precursor] |
Molecular weight: 128790 Da [This is the MW of the unprocessed precursor] |
CRC64: 12D32BAC7080CB5A [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSRSVLQPSQ QKLAEKLTIL NDRGVGMLTR LYNIKKACGD PKAKPSYLID KNLESAVKFI
70 80 90 100 110 120
VRKFPAVETR NNNQQLAQLQ KEKSEILKNL ALYYFTFVDV MEFKDHVCEL LNTIDVCQVF
130 140 150 160 170 180
FDITVNFDLT KNYLDLIITY TTLMILLSRI EERKAIIGLY NYAHEMTHGA SDREYPRLGQ
190 200 210 220 230 240
MIVDYENPLK KMMEEFVPHS KSLSDALISL QMVYPRRNLS ADQWRNAQLL SLISAPSTML
250 260 270 280 290 300
NPAQSDTMPC EYLSLDAMEK WIIFGFILCH GILNTDATAL NLWKLALQSS SCLSLFRDEV
310 320 330 340 350 360
FHIHKAAEDL FVNIRGYNKR INDIRECKEA AVSHAGSMHR ERRKFLRSAL KELATVLSDQ
370 380 390 400 410 420
PGLLGPKALF VFMALSFARD EIIWLLRHAD NMPKKSADDF IDKHIAELIF YMEELRAHVR
430 440 450 460 470 480
KYGPVMQRYY VQYLSGFDAV VLNELVQNLS VCPEDESIIM SSFVNTMTSL SVKQVEDGEV
490 500 510 520 530 540
FDFRGMRLDW FRLQAYTSVS KASLGLADHR ELGKMMNTII FHTKMVDSLV EMLVETSDLS
550 560 570 580 590 600
IFCFYSRAFE KMFQQCLELP SQSRYSIAFP LLCTHFMSCT HELCPEERHH IGDRSLSLCN
610 620 630 640 650 660
MFLDEMAKQA RNLITDICTE QCTLSDQLLP KHCAKTISQA VNKKSKKQTG KKGEPEREKP
670 680 690 700 710 720
GVESMRKNRL VVTNLDKLHT ALSELCFSIN YVPNMVVWEH TFTPREYLTS HLEIRFTKSI
730 740 750 760 770 780
VGMTMYNQAT QEIAKPSELL TSVRAYMTVL QSIENYVQID ITRVFNNVLL QQTQHLDSHG
790 800 810 820 830 840
EPTITSLYTN WYLETLLRQV SNGHIAYFPA MKAFVNLPTE NELTFNAEEY SDISEMRSLS
850 860 870 880 890 900
ELLGPYGMKF LSESLMWHIS SQVAELKKLV VENVDVLTQM RTSFDKPDQM AALFKRLSSV
910 920 930 940 950 960
DSVLKRMTII GVILSFRSLA QEALRDVLSY HIPFLVSSIE DFKDHIPRET DMKVAMNVYE
970 980 990 1000 1010 1020
LSSAAGLPCE IDPALVVALS SQKSENISPE EEYKIACLLM VFVAVSLPTL ASNVMSQYSP
1030 1040 1050 1060 1070 1080
AIEGHCNNIH CLAKAINQIA AALFTIHKGS IEDRLKEFLA LASSSLLKIG QETDKTTTRN
1090 1100 1110 1120
RESVYLLLDM IVQESPFLTM DLLESCFPYV LLRNAYHAVY KQSVTSSA
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Q9Y2A7 in FASTA format |
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