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UniProtKB/Swiss-Prot entry Q9WV31


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARC_MOUSE
Primary accession number Q9WV31
Secondary accession number Q9ES15
Integrated into Swiss-Prot on January 23, 2007
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name Activity-regulated cytoskeleton-associated protein
Synonyms Activity-regulated gene 3.1 protein homolog
Arg3.1
ARC/ARG3.1
mArc
Gene name
Name: Arc
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=11466419 [NCBI, ExPASy, EBI, Israel, Japan]
Waltereit R., Dammermann B., Wulff P., Scafidi J., Staubli U., Kauselmann G., Bundman M., Kuhl D.;
"Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation.";
J. Neurosci. 21:5484-5493(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6;
TISSUE=Forebrain;
Chowdhury S., Lanahan A.A., Worley P.F.;
"The mArc gene, a mouse homolog of rat Arc.";
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD;
TISSUE=Dendritic cell, and Embryo;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-242.
STRAIN=C57BL/6 X CBA;
Medrano S., Worley P.F., Chowdhury S., Lanahan A., Steward O., Scrable H.;
"Characterization of the promoter region of the immediate early gene Arc.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[6]
SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
DOI=10.1095/biolreprod.102.004143; PubMed=12493697 [NCBI, ExPASy, EBI, Israel, Japan]
Maier B., Medrano S., Sleight S.B., Visconti P.E., Scrable H.;
"Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tail.";
Biol. Reprod. 68:67-76(2003).
[7]
FUNCTION, AND NULL MUTANT.
DOI=10.1016/j.neuron.2006.08.024; PubMed=17088210 [NCBI, ExPASy, EBI, Israel, Japan]
Plath N., Ohana O., Dammermann B., Errington M.L., Schmitz D., Gross C., Mao X., Engelsberg A., Mahlke C., Welzl H., Kobalz U., Stawrakakis A., Fernandez E., Waltereit R., Bick-Sander A., Therstappen E., Cooke S.F., Blanquet V., Wurst W., Salmen B., Bosl M.R., Lipp H.P., Grant S.G., Bliss T.V., Wolfer D.P., Kuhl D.;
"Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.";
Neuron 52:437-444(2006).
[8]
FUNCTION.
DOI=10.1016/j.neuron.2006.08.034; PubMed=17088213 [NCBI, ExPASy, EBI, Israel, Japan]
Shepherd J.D., Rumbaugh G., Wu J., Chowdhury S., Plath N., Kuhl D., Huganir R.L., Worley P.F.;
"Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA Receptors.";
Neuron 52:475-484(2006).
Comments
  • FUNCTION: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
  • SUBUNIT: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (By similarity).
  • SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Endosome (By similarity). Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse (By similarity). Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines (By similarity). Associated with the sperm tail.
  • TISSUE SPECIFICITY: Expressed in brain and testis.
  • DEVELOPMENTAL STAGE: Detectable in brain from postnatal week 1, in testis from postnatal week 3.
  • MISCELLANEOUS: Mice lacking Arc show deficits in several forms of long-term memory formation including spatial and fear-related learning, conditioned taste aversion as well as long-term object recognition. They show enhanced early-phase but impaired late-phase long-term potentiation (LTP) as well as impaired long-term depression (LTD). Neurons lacking Arc show an increase in surface levels of AMPA receptors.
  • MISCELLANEOUS: Widely used as activity-dependent neuronal marker to identify recently activated neurons in behavioral studies.
  • SIMILARITY: Belongs to the ARC/ARG3.1 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF177701; AAK91587.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF162777; AAD43586.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK157822; BAE34212.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK170446; BAE41804.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC023127; AAH23127.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF254662; AAG10254.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_061260.1; -.
UniGene Mm.25405
3D structure databases
ModBase Q9WV31.
Protein-protein interaction databases
IntAct Q9WV31; -.
Organism-specific databases
MGI MGI:88067; Arc.
Gene expression databases
ArrayExpress Q9WV31; -.
Ontologies
GO
GO:0005856; Cellular component: cytoskeleton (traceable author statement from MGI).
GO:0003779; Molecular function: actin binding (traceable author statement from MGI).
GO:0009952; Biological process: anterior/posterior pattern formation (inferred from mutant phenotype from MGI).
GO:0007492; Biological process: endoderm development (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
BLOCKS Q9WV31.
Genome annotation databases
Ensembl ENSMUSG00000022602; Mus musculus. [Contig view]
GeneID 11838; -.
KEGG mmu:11838; -.
Phylogenomic databases
HOVERGEN Q9WV31; -.
Other
SOURCE Arc; Mus musculus.
ProtoNet Q9WV31.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell junction; Cell membrane; Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein; Endocytosis; Endosome; Membrane; Postsynaptic cell membrane; Synapse.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   396  396     Activity-regulated cytoskeleton-associated protein. PRO_0000273286
REGION   89   100  12     Binds SH3GL1 or SH3GL3 (By similarity). 
REGION   195   214  20     Required for binding DNM2 (By similarity). 
COILED   54    78  25     Potential. 
Sequence information
Length: 396 AA [This is the length of the unprocessed precursor] Molecular weight: 45321 Da [This is the MW of the unprocessed precursor] CRC64: F4D3505FD477D18A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MELDHMTTGG LHAYPAPRGG PAAKPNVILQ IGKCRAEMLE HVRRTHRHLL TEVSKQVERE 

        70         80         90        100        110        120 
LKGLHRSVGK LENNLDGYVP TGDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF 

       130        140        150        160        170        180 
YRLERWADRL ESMGGKYPVG SEPARHTVSV GVGGPEPYCQ EADGYDYTVS PYAITPPPAA 

       190        200        210        220        230        240 
GELPEQESVE AQQYQSWGPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS 

       250        260        270        280        290        300 
QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELEL PQKQGEPLDQ 

       310        320        330        340        350        360 
FLWRKRDLYQ TLYVDAEEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDGLE 

       370        380        390 
QAAEPSGTPL PTEDETEALT PALTSESVAS DRTQPE 

Q9WV31 in FASTA format

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