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UniProtKB/Swiss-Prot entry Q9WU72

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TN13B_MOUSE
Primary accession number Q9WU72
Secondary accession numbers None
Integrated into Swiss-Prot on February 21, 2001
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 69)
Name and origin of the protein
Protein name Tumor necrosis factor ligand superfamily member 13B
Synonyms B cell-activating factor
BAFF
CD257 antigen
Contains Tumor necrosis factor ligand superfamily member 13b, membrane form
Tumor necrosis factor ligand superfamily member 13b, soluble form
Gene name
Name: Tnfsf13b
Synonyms: Baff
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1084/jem.189.11.1747; PubMed=10359578 [NCBI, ExPASy, EBI, Israel, Japan]
Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.-L., Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H., Valmori D., Romero P., Werner-Favre C., Zubler R.H., Browning J.L., Tschopp J.;
"BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.";
J. Exp. Med. 189:1747-1756(1999).
[2]
 NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-79.
STRAIN=NZB;
DOI=10.1007/s00251-001-0396-6; PubMed=11862414 [NCBI, ExPASy, EBI, Israel, Japan]
Jiang Y., Ohtsuji M., Abe M., Li N., Xiu Y., Wen X.S., Shirai T., Hirose S.;
"Polymorphism and chromosomal mapping of the mouse gene for B-cell activating factor belonging to the tumor necrosis factor family (Baff) and association with the autoimmune phenotype.";
Immunogenetics 53:810-813(2001).
Comments
  • FUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
  • SUBUNIT: Homotrimer.
  • SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.
  • SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.
  • PTM: The soluble form derives from the membrane form by proteolytic processing.
  • SIMILARITY: Belongs to the tumor necrosis factor family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF119383; AAD22475.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF352245; AAL83939.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00124038; -.
RefSeq NP_296371.1; -.
UniGene Mm.28835
3D structure databases
HSSP Q9Y275; 1KXG. [HSSP ENTRY / PDB]
SMR Q9WU72; 166-309.
ModBase Q9WU72.
Organism-specific databases
MGI MGI:1344376; Tnfsf13b.
Gene expression databases
ArrayExpress Q9WU72; -.
Bgee Q9WU72; -.
GermOnline ENSMUSG00000031497; Mus musculus.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005125; Molecular function: cytokine activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005164; Molecular function: tumor necrosis factor receptor binding (inferred from electronic annotation from InterPro).
GO:0031296; Biological process: B cell costimulation (inferred from direct assay from MGI).
GO:0001782; Biological process: B cell homeostasis (inferred from mutant phenotype from MGI).
GO:0048305; Biological process: immunoglobulin secretion (inferred from genetic interaction from MGI).
GO:0030890; Biological process: positive regulation of B cell proliferation (inferred from direct assay from MGI).
GO:0002636; Biological process: positive regulation of germinal center formation (inferred from mutant phenotype from MGI).
GO:0045885; Biological process: positive regulation of survival gene product expression (inferred from direct assay from MGI).
GO:0042102; Biological process: positive regulation of T cell proliferation (inferred from direct assay from MGI).
GO:0031295; Biological process: T cell costimulation (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR006052; TNF_family.
IPR008983; Tumour_necrosis_fac-like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1.
Pfam PF00229; TNF; 1.
Pfam graphical view of domain structure.
SMART SM00207; TNF; 1.
SMART graphical view of domain structure.
PROSITE PS00251; TNF_1; FALSE_NEG.
PS50049; TNF_2; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSMUSG00000031497; Mus musculus. [Contig view]
GeneID 24099; -.
KEGG mmu:24099; -.
Phylogenomic databases
HOGENOM Q9WU72; -.
HOVERGEN Q9WU72; -.
OMA Q9WU72; LALLSCC.
Other
NextBio 304105; -.
SOURCE Tnfsf13b; Mus musculus.
ProtoNet Q9WU72.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Secreted; Signal-anchor; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   309  309     Tumor necrosis factor ligand superfamily member 13b, membrane form. PRO_0000034530
CHAIN   127   309  183     Tumor necrosis factor ligand superfamily member 13b, soluble form. PRO_0000034531
TOPO_DOM   1    47  47     Cytoplasmic (Potential). 
TRANSMEM   48    68  21     Signal-anchor for type II membrane protein (Potential). 
TOPO_DOM   69   309  241     Extracellular (Potential). 
SITE   126   127  2     Cleavage (By similarity). 
CARBOHYD   117   117        N-linked (GlcNAc...) (Potential). 
CARBOHYD   266   266        N-linked (GlcNAc...) (Potential). 
DISULFID   256   269        By similarity. 
VARIANT   79    79  1     N -> S (in strain: NZB). 
Sequence information
Length: 309 AA [This is the length of the unprocessed precursor] Molecular weight: 34192 Da [This is the MW of the unprocessed precursor] CRC64: F3DE6056E66034B4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDESAKTLPP PCLCFCSEKG EDMKVGYDPI TPQKEEGAWF GICRDGRLLA ATLLLALLSS 

        70         80         90        100        110        120 
SFTAMSLYQL AALQADLMNL RMELQSYRGS ATPAAAGAPE LTAGVKLLTP AAPRPHNSSR 

       130        140        150        160        170        180 
GHRNRRAFQG PEETEQDVDL SAPPAPCLPG CRHSQHDDNG MNLRNIIQDC LQLIADSDTP 

       190        200        210        220        230        240 
TIRKGTYTFV PWLLSFKRGN ALEEKENKIV VRQTGYFFIY SQVLYTDPIF AMGHVIQRKK 

       250        260        270        280        290        300 
VHVFGDELSL VTLFRCIQNM PKTLPNNSCY SAGIARLEEG DEIQLAIPRE NAQISRNGDD 


TFFGALKLL
Q9WU72 in FASTA format

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