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UniProtKB/Swiss-Prot entry Q9W1K5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SEST_DROME
Primary accession number Q9W1K5
Secondary accession number Q9I7V1
Integrated into Swiss-Prot on April 27, 2001
Sequence was last modified on April 27, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Putative sestrin
Synonyms None
Gene name
ORFNames: CG11299
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=Berkeley;
TISSUE=Embryo;
PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan]
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185 AND SER-190, AND MASS SPECTROMETRY.
TISSUE=Embryo;
DOI=10.1021/pr700696a; PubMed=18327897 [NCBI, ExPASy, EBI, Israel, Japan]
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
J. Proteome Res. 7:1675-1682(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE013599; AAF47053.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY069626; AAL39771.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001097437.1; -.
NP_001097438.1; -.
NP_611821.1; -.
UniGene Dm.2037
3D structure databases
ModBase Q9W1K5.
Protein-protein interaction databases
DIP DIP:19601N; -.
IntAct Q9W1K5; -.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-006283-MON; -.
Organism-specific databases
FlyBase FBgn0034897; CG11299.
Gene expression databases
ArrayExpress Q9W1K5; -.
GermOnline CG11299; Drosophila melanogaster.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR006730; PA26.
Graphical view of domain structure.
PANTHER PTHR12474; PA26; 1.
Pfam PF04636; PA26; 1.
Pfam graphical view of domain structure.
BLOCKS Q9W1K5.
Genome annotation databases
Ensembl CG11299; Drosophila melanogaster. [Contig view]
GeneID 37755; -.
KEGG dme:Dmel_CG11299; -.
NMPDR fig|7227.3.peg.7121; -.
Phylogenomic databases
HOGENOM Q9W1K5; -.
Other
ProtoNet Q9W1K5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Complete proteome; Nucleus; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   497  497     Putative sestrin. PRO_0000221186
MOD_RES   185   185        Phosphoserine. 
MOD_RES   190   190        Phosphoserine. 
VAR_SEQ   80   111        AAARHQCPYLVKRYEKEFINQGGDSAWLGGLD -> SIFRLLFPTFISLPNWPKTIAIDWANEEHGLL (in isoform 2). VSP_006065
VAR_SEQ   112   497        Missing (in isoform 2). VSP_006066
VAR_SEQ   433   437        LLVRP -> VRNQL (in isoform 3). VSP_006067
VAR_SEQ   438   497        Missing (in isoform 3). VSP_006068
Sequence information
Length: 497 AA [This is the length of the unprocessed precursor] Molecular weight: 55853 Da [This is the MW of the unprocessed precursor] CRC64: 39AC03B8F653CA30 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MYYAVDYYAD MGQISQDCFA ATQTGASDFD MDELDDLDQV TQVIGYHPQF HDHFLATQNF 

        70         80         90        100        110        120 
IMKGDGPLPN DYRYYLAIIA AARHQCPYLV KRYEKEFINQ GGDSAWLGGL DFIPAKLRAI 

       130        140        150        160        170        180 
YDINKILAHR PWLLRKEHIE RLTKGKNSWS LSEVVHAMVL LSHFHSLSSF VFSCGLTQKL 

       190        200        210        220        230        240 
DGLSSPKLKS PPAAVAALAP TILITPTSPT EPQKGKPVLA EISLNNANPD YDSQTAASSN 

       250        260        270        280        290        300 
GGAPPDSANA VADGPDATTL NGYLATAQQL PQQHGISVET LMERMKVLSQ KQDECSEAEL 

       310        320        330        340        350        360 
SSRFQKVEQQ TAELAAVTPE AAVGVPTNLS HYVDDANFIY QDFARRGTES INTFRIQDYS 

       370        380        390        400        410        420 
WEDHGYSLVD GLYNDVGIFL DAKFRAAYNL TYCTMGGIKN VDTSKFRRAI WNYIQCIYGI 

       430        440        450        460        470        480 
RHDDYDYGEV NQLLVRPLKM FIKTACCFPE RITTKDYDSV LVELQDSEKV HVNLMIMEAR 

       490 
NQAELLYALR EIMRYMT 

Q9W1K5 in FASTA format

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