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UniProtKB/Swiss-Prot entry Q9V574


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name L2K1_DROME
Primary accession number Q9V574
Secondary accession number P91662
Integrated into Swiss-Prot on July 19, 2003
Sequence was last modified on June 1, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 48)
Name and origin of the protein
Protein name Protein lethal(2)k10201
Synonym Wunen region B protein
Gene name
Name: l(2)k10201
ORFNames: CG13951
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
DOI=10.1038/385064a0; PubMed=8985246 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang N., Zhang J.P., Purcell K.J., Chen Y., Howard K.;
"The Drosophila protein Wunen repels migrating germ cells.";
Nature 385:64-67(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U73823; AAC47450.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE013599; AAF58944.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_788296.1; -.
UniGene Dm.27473
3D structure databases
ModBase Q9V574.
Protein-protein interaction databases
DIP DIP:19602N; -.
IntAct Q9V574; -.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-003625-MON; -.
Organism-specific databases
FlyBase FBgn0016970; l(2)k10201.
Gene expression databases
ArrayExpress Q9V574; -.
GermOnline CG13951; Drosophila melanogaster.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0007275; Biological process: multicellular organismal development (inferred from mutant phenotype from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
Graphical view of domain structure.
SMART SM00355; ZnF_C2H2; 2.
SMART graphical view of domain structure.
PROSITE PS00028; ZINC_FINGER_C2H2_1; 2.
PS50157; ZINC_FINGER_C2H2_2; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9V574.
Genome annotation databases
Ensembl CG13951; Drosophila melanogaster. [Contig view]
GeneID 48373; -.
KEGG dme:Dmel_CG13951; -.
NMPDR fig|7227.3.peg.4072; -.
Phylogenomic databases
HOGENOM Q9V574; -.
Other
ProtoNet Q9V574.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Developmental protein; Metal-binding; Repeat; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   221  221     Protein lethal(2)k10201. PRO_0000046927
ZN_FING   74    97  24     C2H2-type 1. 
ZN_FING   113   138  26     C2H2-type 2. 
Sequence information
Length: 221 AA [This is the length of the unprocessed precursor] Molecular weight: 24962 Da [This is the MW of the unprocessed precursor] CRC64: CC906EC62398DAD9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDSEAAGVAL LSREQIIRIL SEVPAGFIKP TDPPAPSLAP FKKLGVLVDI DDILGEQDAA 

        70         80         90        100        110        120 
AARIRDNIDK EQSYSCVECR KMLPTAHLLD LHITEQHDCY FAASVERGDK PMFSCFLEEC 

       130        140        150        160        170        180 
TIKFHTARQR KDHCIITHKL PANYRFDHSK NRGKQKHQGK SKPNSMEVDE VIEETKSLPY 

       190        200        210        220 
VKAFSFGHQT QRSFYTGKDQ RSGKTLDDVQ AMKEAINDIL D 

Q9V574 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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