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UniProtKB/Swiss-Prot entry Q9UYR1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GYAR_PYRAB
Primary accession number Q9UYR1
Secondary accession numbers None
Integrated into Swiss-Prot on May 10, 2004
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name Glyoxylate reductase
Synonym EC 1.1.1.26
Gene name
Name: gyaR
OrderedLocusNames: PYRAB14460
ORFNames: PAB2374
From
Pyrococcus abyssi [TaxID: 29292] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=GE5 / Orsay;
DOI=10.1046/j.1365-2958.2003.03381.x; PubMed=12622808 [NCBI, ExPASy, EBI, Israel, Japan]
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi.";
Mol. Microbiol. 47:1495-1512(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ248287; CAB50351.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B75057; B75057.
RefSeq NP_127121.1; -.
3D structure databases
HSSP P36234; 1GDH. [HSSP ENTRY / PDB]
SMR Q9UYR1; 3-334.
ModBase Q9UYR1.
Enzyme and pathway databases
BioCyc PABY272844:PAB2374-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0047964; Molecular function: glyoxylate reductase activity (inferred from electronic annotation from HAMAP).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00776; -; 1.
PBIL [Tree]
InterPro IPR006139; D-isomer_2_OHA_DHase.
IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00389; 2-Hacid_dh; 1.
PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1.
PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
PS00671; D_2_HYDROXYACID_DH_3; 1.
ProtoNet Q9UYR1.
Genome annotation databases
GeneID 1495721; -.
GenomeReviews AL096836_GR; PYRAB14460.
KEGG pab:PAB2374; -.
NMPDR fig|272844.1.peg.1531; -.
Phylogenomic databases
HOGENOM Q9UYR1; -.
Genome annotation databases
CMR Q9UYR1; PYRAB14460.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   335  335     Glyoxylate reductase. PRO_0000075947
NP_BIND   159   162  4     NADP (By similarity). 
NP_BIND   181   183  3     NADP (By similarity). 
NP_BIND   240   242  3     NADP (By similarity). 
NP_BIND   289   291  3     NADP (By similarity). 
ACT_SITE   242   242        By similarity. 
ACT_SITE   271   271        By similarity. 
ACT_SITE   289   289        Proton donor (By similarity). 
Sequence information
Length: 335 AA [This is the length of the unprocessed precursor] Molecular weight: 38270 Da [This is the MW of the unprocessed precursor] CRC64: 32CEA1CB7126A0B4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKPRVFITR EIPEVGIEML EKEFEVEVWE DEREIPREIL LEKVKDVDAL VTMLSERIDR 

        70         80         90        100        110        120 
EVFERAPRLR IVANYAVGYD NIDVEEATKR GIYVTNTPGV LTDATADLAF ALLLATARHL 

       130        140        150        160        170        180 
VKGDKFTRSG EWKKRGVAWH PKWFLGYDVY GKTIGIIGFG RIGQAIAKRA RGFDMRILYY 

       190        200        210        220        230        240 
SRTRKPEVEK ELNAEFKPLD ELLRESDFVV LAVPLNKETY HMINEERLKM MKRTAILINV 

       250        260        270        280        290        300 
ARGKVIDTKA LIKALKEGWI AGAGLDVYEE EPYYNEELFS LDNVVLTPHI GSATFGAREG 

       310        320        330 
MAKLVAENLI AFKRGEVPPT LVNREVLKVR KPGFQ
Q9UYR1 in FASTA format

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