[1]	NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, AND TISSUE SPECIFICITY. TISSUE=Small intestine; DOI=10.1042/0264-6021:3420721; PubMed=10477285 [NCBI, ExPASy, EBI, Israel, Japan] Arimitsu E., Aoki S., Ishikura S., Nakanishi K., Matsuura K., Hara A.; "Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases."; Biochem. J. 342:721-728(1999).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.; Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Uterus; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

CATALYTIC ACTIVITY: Trans-1,2-dihydrobenzene-1,2-diol + NADP⁺ = catechol + NADPH.
CATALYTIC ACTIVITY: D-xylose + NADP⁺ = D-xylono-1,5-lactone + NADPH.
SUBUNIT: Homodimer.
TISSUE SPECIFICITY: Small intestine.
SIMILARITY: Belongs to the gfo/idh/mocA family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC032730; AAH32730.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB021933; BAA83490.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471177; EAW52414.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_055290.1; -.

UniGene

Hs.631555

3D structure databases

ModBase

Q9UQ10.

Organism-specific databases

HGNC:17887; DHDH.

606377; gene. [NCBI / EBI]

PharmGKB

PA27322; -.

GeneCards

Q9UQ10.

Gene expression databases

ArrayExpress

Q9UQ10; -.

CleanEx

HS_DHDH; -.

Ontologies

GO:0005488;	Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0047837;	Molecular function: D-xylose 1-dehydrogenase (NADP+) activity (inferred from electronic annotation from EC).
GO:0009055;	Molecular function: electron carrier activity (traceable author statement from UniProtKB).
GO:0008746;	Molecular function: NAD(P) transhydrogenase activity (traceable author statement from ProtInc).
GO:0047115;	Molecular function: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0005975;	Biological process: carbohydrate metabolic process (traceable author statement from ProtInc).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000683; GFO/IDH/MocA_N.
IPR016040; NAD(P)-bd.
IPR004104; OxRdtase_C.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01408; GFO_IDH_MocA; 1.
PF02894; GFO_IDH_MocA_C; 1.
Pfam graphical view of domain structure.

ProtoNet

Q9UQ10.

Genome annotation databases

Ensembl

ENSG00000104808; Homo sapiens. [Contig view]

GeneID

27294; -.

KEGG

hsa:27294; -.

Phylogenomic databases

HOGENOM

Q9UQ10; -.

HOVERGEN

Q9UQ10; -.

Other

NextBio

50258; -.

SOURCE

DHDH; Homo sapiens.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NADP; Oxidoreductase; Polymorphism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 334`	`334`	`Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.`	`PRO_0000315361`
`SITE`	`71 71`	`1`	`May play an important role in coenzyme binding (By similarity).`
`SITE`	`79 79`	`1`	`May play an important role in coenzyme binding (By similarity).`
`SITE`	`97 97`	`1`	`May play an important role in coenzyme binding (By similarity).`
`SITE`	`176 176`	`1`	`May play an important role for the adaptation of the alcohol substrate into the binding site (By similarity).`
`SITE`	`180 180`	`1`	`May play an important role in catalytic activity (By similarity).`
`VARIANT`	`2 2`	`1`	`A -> P (in dbSNP:rs10401800 [NCBI]).`	`VAR_038174 [3D]`
`VARIANT`	`66 66`	`1`	`S -> N (in dbSNP:rs2270941 [NCBI]).`	`VAR_038175 [3D]`
`VARIANT`	`200 200`	`1`	`V -> M (in dbSNP:rs35453148 [NCBI]).`	`VAR_038176 [3D]`
`VARIANT`	`247 247`	`1`	`V -> A (in dbSNP:rs11666105 [NCBI]).`	`VAR_038177 [3D]`
`VARIANT`	`282 282`	`1`	`G -> R (in dbSNP:rs3765148 [NCBI]).`	`VAR_038178 [3D]`

Sequence information

Length: 334 AA [This is the length of the unprocessed precursor]

Molecular weight: 36382 Da [This is the MW of the unprocessed precursor]

CRC64: 1E2E11DF0B55214B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD IPKAYGSYEE 

        70         80         90        100        110        120 
LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG VNAAEVREMV AEARSRALFL 

       130        140        150        160        170        180 
MEAIWTRFFP ASEALRSVLA QGTLGDLRVA RAEFGKNLIH VPRAVDRAQA GGALLDIGIY 

       190        200        210        220        230        240 
CVQFTSMVFG GQKPEKISVV GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV 

       250        260        270        280        290        300 
SGTKGMVQLL NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM 

       310        320        330 
KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR

Q9UQ10 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools