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UniProtKB/Swiss-Prot entry Q9QXJ1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name APBB1_MOUSE
Primary accession number Q9QXJ1
Secondary accession numbers O08642 Q3TPU0 Q8BNF4 Q8BSR9
Integrated into Swiss-Prot on January 11, 2001
Sequence was last modified on September 27, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name Amyloid beta A4 precursor protein-binding family B member 1
Synonym Fe65 protein
Gene name
Name: Apbb1
Synonyms: Fe65
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Liakicheva A.V., Ivanova N.B., Belyavsky A.V.;
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6J;
TISSUE=Hippocampus, and Spinal ganglion;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 498-674.
TISSUE=Embryo;
DOI=10.1093/hmg/5.10.1589; PubMed=8894693 [NCBI, ExPASy, EBI, Israel, Japan]
Bressler S.L., Gray M.D., Sopher B.L., Hu Q., Hearn M.G., Pham D.G., Dinulos M.B., Fukuchi K., Sisodia S.S., Miller M.A., Disteche C.M., Martin G.M.;
"cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.";
Hum. Mol. Genet. 5:1589-1598(1996).
[4]
INTERACTION WITH APBB1IP AND ENAH, AND MUTAGENESIS OF TRP-280 AND PRO-283.
DOI=10.1074/jbc.272.52.32869; PubMed=9407065 [NCBI, ExPASy, EBI, Israel, Japan]
Ermekova K.S., Zambrano N., Linn H., Minopoli G., Gertler F., Russo T., Sudol M.;
"The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.";
J. Biol. Chem. 272:32869-32877(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF206720; AAF20141.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK030748; BAC27116.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK083830; BAC39033.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK164140; BAE37645.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L77865; AAB51603.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_033815.1; -.
UniGene Mm.38469
3D structure databases
SMR Q9QXJ1; 241-290.
ModBase Q9QXJ1.
Protein-protein interaction databases
IntAct Q9QXJ1; -.
PTM databases
PhosphoSite Q9QXJ1; -.
Organism-specific databases
MGI MGI:107765; Apbb1.
Gene expression databases
ArrayExpress Q9QXJ1; -.
GermOnline ENSMUSG00000037032; Mus musculus.
Ontologies
GO
GO:0030426; Cellular component: growth cone (inferred from sequence or structural similarity from UniProtKB).
GO:0030027; Cellular component: lamellipodium (inferred from sequence or structural similarity from UniProtKB).
GO:0005634; Cellular component: nucleus (inferred from direct assay from UniProtKB).
GO:0045202; Cellular component: synapse (inferred from sequence or structural similarity from UniProtKB).
GO:0001540; Molecular function: beta-amyloid binding (inferred from sequence or structural similarity from UniProtKB).
GO:0035035; Molecular function: histone acetyltransferase binding (non-traceable author statement from UniProtKB).
GO:0008134; Molecular function: transcription factor binding (inferred from direct assay from UniProtKB).
GO:0030048; Biological process: actin filament-based movement (non-traceable author statement from UniProtKB).
GO:0007411; Biological process: axon guidance (inferred from genetic interaction from MGI).
GO:0007050; Biological process: cell cycle arrest (inferred from direct assay from UniProtKB).
GO:0030198; Biological process: extracellular matrix organization and biogenesis (inferred from genetic interaction from MGI).
GO:0030308; Biological process: negative regulation of cell growth (inferred from direct assay from UniProtKB).
GO:0045749; Biological process: negative regulation of S phase of mitotic cell cycle (inferred from direct assay from UniProtKB).
GO:0050760; Biological process: negative regulation of thymidylate synthase biosynthetic process (inferred from direct assay from UniProtKB).
GO:0001764; Biological process: neuron migration (inferred from genetic interaction from MGI).
GO:0045944; Biological process: positive regulation of transcription from RNA polymerase II promoter (inferred from genetic interaction from MGI).
GO:0050821; Biological process: protein stabilization (non-traceable author statement from UniProtKB).
GO:0008542; Biological process: visual learning (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR011993; PH_type.
IPR006020; PTB_PID.
IPR001202; WW_Rsp5_WWP.
Graphical view of domain structure.
Gene3D G3DSA:2.30.29.30; PH_type; 2.
Pfam PF00640; PID; 2.
PF00397; WW; 1.
Pfam graphical view of domain structure.
SMART SM00462; PTB; 2.
SM00456; WW; 1.
SMART graphical view of domain structure.
PROSITE PS01179; PID; 2.
PS01159; WW_DOMAIN_1; 1.
PS50020; WW_DOMAIN_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9QXJ1.
Genome annotation databases
Ensembl ENSMUSG00000037032; Mus musculus. [Contig view]
GeneID 11785; -.
KEGG mmu:11785; -.
Phylogenomic databases
HOGENOM Q9QXJ1; -.
HOVERGEN Q9QXJ1; -.
Other
SOURCE Apbb1; Mus musculus.
ProtoNet Q9QXJ1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   710  710     Amyloid beta A4 precursor protein-binding family B member 1. PRO_0000076050
DOMAIN   253   285  33     WW. 
DOMAIN   370   509  140     PID 1. 
DOMAIN   542   699  158     PID 2. 
COMPBIAS   158   171  14     Glu-rich. 
VAR_SEQ   462   463        Missing (in isoform 2). VSP_011659
MUTAGEN   280   280        W->F: Abolishes ligand binding; when associated with A-283. 
MUTAGEN   283   283        P->A: Abolishes ligand binding; when associated with F-280. 
CONFLICT   92    92        T -> A (in Ref. 1; AAF20141). 
CONFLICT   313   313        E -> D (in Ref. 1; AAF20141). 
CONFLICT   630   630        A -> S (in Ref. 2; BAC39033). 
Sequence information
Length: 710 AA [This is the length of the unprocessed precursor] Molecular weight: 77468 Da [This is the MW of the unprocessed precursor] CRC64: 9E1A121C5408F979 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSVPSSLSQS AINANSHGGP ALSFPLPLHA AHNQLLNAKL QATAVVPKDL RSAMGEGSVP 

        70         80         90        100        110        120 
EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEAETAPLGP KGLMHLYSEL 

       130        140        150        160        170        180 
ELSAHNAANR GLHGSALIIN TQEQGPDEGE EKAAGEAEED DEDEEEEEEE EDLSSPPGLP 

       190        200        210        220        230        240 
EPLENVEVPS GPQALTDGPR EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT 

       250        260        270        280        290        300 
DSFWNPNAFE TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL 

       310        320        330        340        350        360 
TWTGFAHQEG FEEGEFWKDE PSEEAPMELG LKDPEEATLS FPAQSLSPEP VPQEEEKLSQ 

       370        380        390        400        410        420 
RNANPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ LSYHKNNLHD PMAGGWGEGK 

       430        440        450        460        470        480 
DLLLQLEDET LKLVEPQNQT LLHAQPIVSI RVWGVGRDSG RERDFAYVAR DKLTQMLKCH 

       490        500        510        520        530        540 
VFRCEAPAKN IATSLHEICS KIMSERRNAR CLVNGLSLDH SKLVDVPFQV EFPAPKNELV 

       550        560        570        580        590        600 
QKFQVYYLGN VPVAKPVGVD VINGALESVL SSSSREQWTP SHVSVAPATL TILHQQTEAV 

       610        620        630        640        650        660 
LGECRVRFLS FLAVGRDVHT FAFIMAAGPA SFCCHMFWCE PNAASLSEAV QAACMLRYQK 

       670        680        690        700        710 
CLDARSQTST SCLPAPPAES VARRVGWTVR RGVQSLWGSL KPKRLGSQTP 

Q9QXJ1 in FASTA format

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View entry in raw text format (no links)
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