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UniProtKB/Swiss-Prot entry Q9P0W0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IFNK_HUMAN
Primary accession number Q9P0W0
Secondary accession number Q5T166
Integrated into Swiss-Prot on March 1, 2005
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Interferon kappa [Precursor]
Synonym IFN-kappa
Gene name
Name: IFNK
ORFNames: UNQ6124/PRO20084
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Cao X., Zhang W.;
"Novel human interferon.";
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.M102502200; PubMed=11514542 [NCBI, ExPASy, EBI, Israel, Japan]
LaFleur D.W., Nardelli B., Tsareva T., Mather D., Feng P., Semenuk M., Taylor K., Buergin M., Chinchilla D., Roshke V., Chen G., Ruben S.M., Pitha P.M., Coleman T.A., Moore P.A.;
"Interferon-kappa, a novel type I interferon expressed in human keratinocytes.";
J. Biol. Chem. 276:39765-39771(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LYS-133.
DOI=10.1038/nature02465; PubMed=15164053 [NCBI, ExPASy, EBI, Israel, Japan]
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[5]
PROTEIN SEQUENCE OF 28-42.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[6]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=12391192 [NCBI, ExPASy, EBI, Israel, Japan]
Nardelli B., Zaritskaya L., Semenuk M., Cho Y.H., LaFleur D.W., Shah D., Ullrich S., Girolomoni G., Albanesi C., Moore P.A.;
"Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system.";
J. Immunol. 169:4822-4830(2002).
Comments
  • FUNCTION: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.
  • SUBCELLULAR LOCATION: Secreted.
  • TISSUE SPECIFICITY: Expressed in keratinocytes, monocytes and in resting dendritic cells.
  • INDUCTION: By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.
  • SIMILARITY: Belongs to the alpha/beta interferon family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF146759; AAF67468.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF315688; AAK01623.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF384048; AAK63835.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358855; AAQ89214.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL451123; CAI13042.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_064509.2; -.
UniGene Hs.591083
3D structure databases
HSSP P56828; 1B5L. [HSSP ENTRY / PDB]
ModBase Q9P0W0.
PTM databases
PhosphoSite Q9P0W0; -.
Organism-specific databases
H-InvDB HIX0034769; -.
HGNC HGNC:21714; IFNK.
GenAtlas IFNK.
PharmGKB PA134970126; -.
GeneCards Q9P0W0.
Gene expression databases
ArrayExpress Q9P0W0; -.
CleanEx HS_IFNK; -.
GermOnline ENSG00000147896; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0005132; Molecular function: interferon-alpha/beta receptor binding (inferred from direct assay from UniProtKB).
GO:0019221; Biological process: cytokine-mediated signaling pathway (inferred from direct assay from UniProtKB).
GO:0030101; Biological process: natural killer cell activation (non-traceable author statement from UniProtKB).
GO:0008285; Biological process: negative regulation of cell proliferation (non-traceable author statement from UniProtKB).
GO:0045089; Biological process: positive regulation of innate immune response (traceable author statement from UniProtKB).
GO:0045449; Biological process: regulation of transcription (inferred from direct assay from UniProtKB).
GO:0009615; Biological process: response to virus (inferred from expression pattern from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR012351; 4_helix_cytokine_core.
IPR000471; Interferon_abd.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
PANTHER PTHR11691; Interferon_abd; 1.
Pfam PF00143; Interferon; 1.
Pfam graphical view of domain structure.
PRINTS PR00266; INTERFERONAB.
ProDom PD000550; Interferon_abd; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00076; IFabd; 1.
SMART graphical view of domain structure.
PROSITE PS00252; INTERFERON_A_B_D; 1.
ProtoNet Q9P0W0.
Genome annotation databases
Ensembl ENSG00000147896; Homo sapiens. [Contig view]
GeneID 56832; -.
KEGG hsa:56832; -.
Phylogenomic databases
HOGENOM Q9P0W0; -.
HOVERGEN Q9P0W0; -.
Other
NextBio 62232; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antiviral defense; Coiled coil; Cytokine; Direct protein sequencing; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    27  27      
CHAIN   28   207  180     Interferon kappa. PRO_0000016410
COILED   118   148  31     Potential. 
DISULFID   30   128        By similarity. 
DISULFID   59   181        By similarity. 
VARIANT   97    97  1     I -> N (in dbSNP:rs34933275 [NCBI]). VAR_032710 
VARIANT   133   133  1     E -> K (in dbSNP:rs700785 [NCBI]). VAR_021303 
Sequence information
Length: 207 AA [This is the length of the unprocessed precursor] Molecular weight: 25219 Da [This is the MW of the unprocessed precursor] CRC64: 49CF410ECE52B597 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS MSNSFPVECL 

        70         80         90        100        110        120 
RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ HTFKYWKERH LKQIQIGLDQ 

       130        140        150        160        170        180 
QAEYLNQCLE EDENENEDMK EMKENEMKPS EARVPQLSSL ELRRYFHRID NFLKEKKYSD 

       190        200 
CAWEIVRVEI RRCLYYFYKF TALFRRK 

Q9P0W0 in FASTA format

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