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UniProtKB/Swiss-Prot entry Q9NSA1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FGF21_HUMAN
Primary accession number Q9NSA1
Secondary accession number Q8N683
Integrated into Swiss-Prot on April 27, 2001
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 72)
Name and origin of the protein
Protein name Fibroblast growth factor 21 [Precursor]
Synonym FGF-21
Gene name
Name: FGF21
ORFNames: UNQ3115/PRO10196
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0167-4781(00)00067-1; PubMed=10858549 [NCBI, ExPASy, EBI, Israel, Japan]
Nishimura T., Nakatake Y., Konishi M., Itoh N.;
"Identification of a novel FGF, FGF-21, preferentially expressed in the liver.";
Biochim. Biophys. Acta 1492:203-206(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-141 AND PRO-174.
NIEHS SNPs program;
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 29-43.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[7]
FUNCTION.
DOI=10.1172/JCI23606; PubMed=15902306 [NCBI, ExPASy, EBI, Israel, Japan]
Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick J.T., Hawkins E.D., Wroblewski V.J., Li D.-S., Mehrbod F., Jaskunas S.R., Shanafelt A.B.;
"FGF-21 as a novel metabolic regulator.";
J. Clin. Invest. 115:1627-1635(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB021975; BAA99415.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359086; AAQ89444.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ847413; ABI75345.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471177; EAW52402.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC018404; AAH18404.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00017149; -.
RefSeq NP_061986.1; -.
UniGene Hs.283015
3D structure databases
HSSP P03968; 1BAR. [HSSP ENTRY / PDB]
ModBase Q9NSA1.
Organism-specific databases
GeneCards GC19P053951; -.
H-InvDB HIX0027440; -.
HGNC HGNC:3678; FGF21.
GenAtlas FGF21.
MIM 609436; gene. [NCBI / EBI]
PharmGKB PA28117; -.
Gene expression databases
ArrayExpress Q9NSA1; -.
Bgee Q9NSA1; -.
CleanEx HS_FGF21; -.
GermOnline ENSG00000105550; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (traceable author statement from ProtInc).
GO:0005625; Cellular component: soluble fraction (traceable author statement from ProtInc).
GO:0008083; Molecular function: growth factor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0007267; Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR017338; Fibroblast_GF_15/19/21.
IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF037961; FGF-19_FGF-21; 1.
PRINTS PR00263; HBGFFGF.
PR00262; IL1HBGF.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; 1.
Proteomic databases
PRIDE Q9NSA1; -.
Genome annotation databases
Ensembl ENSG00000105550; Homo sapiens. [Contig view]
GeneID 26291; -.
KEGG hsa:26291; -.
Phylogenomic databases
HOGENOM Q9NSA1; -.
HOVERGEN Q9NSA1; -.
OMA Q9NSA1; HPIPDSS.
Other
NextBio 48635; -.
SOURCE FGF21; Homo sapiens.
ProtoNet Q9NSA1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Growth factor; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    28  28      
CHAIN   29   209  181     Fibroblast growth factor 21. PRO_0000008994
VARIANT   141   141  1     G -> S. VAR_055375 
VARIANT   174   174  1     L -> P (in dbSNP:rs739320 [NCBI]). VAR_049064 
CONFLICT   23    23        Missing (in Ref. 2; AAQ89444). 
Sequence information
Length: 209 AA [This is the length of the unprocessed precursor] Molecular weight: 22300 Da [This is the MW of the unprocessed precursor] CRC64: 27925C52A0023823 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY TDDAQQTEAH 

        70         80         90        100        110        120 
LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR FLCQRPDGAL YGSLHFDPEA 

       130        140        150        160        170        180 
CSFRELLLED GYNVYQSEAH GLPLHLPGNK SPHRDPAPRG PARFLPLPGL PPALPEPPGI 

       190        200 
LAPQPPDVGS SDPLSMVGPS QGRSPSYAS 

Q9NSA1 in FASTA format

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