[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 108-131; 220-231 AND 349-393, CHARACTERIZATION, AND MUTAGENESIS OF ARG-336.
TISSUE=Cervix carcinoma;
DOI=10.1016/S1097-2765(02)00548-8; PubMed=12086618 [NCBI, ExPASy, EBI, Israel, Japan]
Nishioka K.,
Rice J.C.,
Sarma K.,
Erdjument-Bromage H.,
Werner J.,
Wang Y.,
Chuikov S.,
Valenzuela P.,
Tempst P.,
Steward R.,
Lis J.T.,
Allis C.D.,
Reinberg D.;
"PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.";
Mol. Cell 9:1201-1213(2002).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 83-103; 109-134; 141-151; 162-172; 221-230; 245-260; 280-297 AND 350-393, CHARACTERIZATION, AND MUTAGENESIS OF HIS-340 AND 385-ILE--HIS-393.
DOI=10.1016/S0960-9822(02)00924-7; PubMed=12121615 [NCBI, ExPASy, EBI, Israel, Japan]
Fang J.,
Feng Q.,
Ketel C.S.,
Wang H.,
Cao R.,
Xia L.,
Erdjument-Bromage H.,
Tempst P.,
Simon J.A.,
Zhang Y.;
"Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.";
Curr. Biol. 12:1086-1099(2002).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tain F.,
Huang S.;
"A novel PR/SET domain-containing gene, SET07, as a candidate tumor suppressor.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
DOI=10.1101/gad.1014902; PubMed=12208845 [NCBI, ExPASy, EBI, Israel, Japan]
Rice J.C.,
Nishioka K.,
Sarma K.,
Steward R.,
Reinberg D.,
Allis C.D.;
"Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.";
Genes Dev. 16:2225-2230(2002).
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[6]
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FUNCTION, AND INDUCTION.
DOI=10.1016/j.molcel.2004.06.008; PubMed=15200950 [NCBI, ExPASy, EBI, Israel, Japan]
Julien E.,
Herr W.;
"A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1.";
Mol. Cell 14:713-725(2004).
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[7]
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CATALYTIC ACTIVITY.
DOI=10.1074/jbc.M501691200; PubMed=15964846 [NCBI, ExPASy, EBI, Israel, Japan]
Yin Y.,
Liu C.,
Tsai S.N.,
Zhou B.,
Ngai S.M.,
Zhu G.;
"SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20.";
J. Biol. Chem. 280:30025-30031(2005).
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[8]
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FUNCTION.
DOI=10.1074/jbc.M513462200; PubMed=16517599 [NCBI, ExPASy, EBI, Israel, Japan]
Sims J.K.,
Houston S.I.,
Magazinnik T.,
Rice J.C.;
"A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin.";
J. Biol. Chem. 281:12760-12766(2006).
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[9]
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X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 233-393 IN COMPLEX WITH HISTONE H4 AND S-ADENOSYLMETHIONINE, AND FUNCTION.
DOI=10.1101/gad.1315905; PubMed=15933069 [NCBI, ExPASy, EBI, Israel, Japan]
Xiao B.,
Jing C.,
Kelly G.,
Walker P.A.,
Muskett F.W.,
Frenkiel T.A.,
Martin S.R.,
Sarma K.,
Reinberg D.,
Gamblin S.J.,
Wilson J.R.;
"Specificity and mechanism of the histone methyltransferase Pr-Set7.";
Genes Dev. 19:1444-1454(2005).
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[10]
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X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 231-393 IN COMPLEX WITH HISTONE H4 AND S-ADENOSYLMETHIONINE, FUNCTION, AND MUTAGENESIS OF TYR-286; GLU-300; CYS-311; TYR-375; ASP-379 AND HIS-388.
DOI=10.1101/gad.1318405; PubMed=15933070 [NCBI, ExPASy, EBI, Israel, Japan]
Couture J.-F.,
Collazo E.,
Brunzelle J.S.,
Trievel R.C.;
"Structural and functional analysis of SET8, a histone H4 'Lys-20' methyltransferase.";
Genes Dev. 19:1455-1465(2005).
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