[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1006/bbrc.2000.3142; PubMed=10913340 [NCBI, ExPASy, EBI, Israel, Japan] Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., Shiokawa K., Katoh M.; "Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22."; Biochem. Biophys. Res. Commun. 274:337-343(2000).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; DOI=10.1006/bbrc.2000.3675; PubMed=11032730 [NCBI, ExPASy, EBI, Israel, Japan] Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N.; "FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain."; Biochem. Biophys. Res. Commun. 277:355-360(2000).
[3]	NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. PubMed=11306498 [NCBI, ExPASy, EBI, Israel, Japan] Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., Lichenstein H.S.; "Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis."; Cancer Res. 61:3131-3138(2001).
[4]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-116; ALA-175 AND ASN-206. Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Chambers S.W., Schackwitz W.S., Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Neurotrophic factor that regulates central nervous development and function.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Predominantly expressed in the cerebellum.
SIMILARITY: Belongs to the heparin-binding growth factors family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB044277; BAB03633.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB030648; BAB03530.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY696296; AAT85804.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

JC7353; JC7353.

NP_062825.1; -.

3D structure databases

HSSP

P31371; 1IHK. [HSSP ENTRY / PDB]

SMR

Q9NP95; 57-208.

ModBase

Q9NP95.

Enzyme and pathway databases

Reactome

REACT_9470; Signaling by FGFR.

Polymorphism databases

NIEHS-SNPs

FGF20.

Organism-specific databases

HIX0034235; -.

HGNC:3677; FGF20.

605558; gene. [NCBI / EBI]

PharmGKB

PA28116; -.

GeneCards

Q9NP95.

Gene expression databases

ArrayExpress

Q9NP95; -.

CleanEx

HS_FGF20; -.

GermOnline

ENSG00000078579; Homo sapiens.

Ontologies

GO:0005576;	Cellular component: extracellular region (traceable author statement from ProtInc).
GO:0005625;	Cellular component: soluble fraction (traceable author statement from ProtInc).
GO:0016049;	Biological process: cell growth (inferred from mutant phenotype from UniProtKB).
GO:0007267;	Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0008543;	Biological process: fibroblast growth factor receptor signaling pathway (inferred from experiment from Reactome).
QuickGo view.

Family and domain databases

InterPro

IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.

PANTHER

PTHR11486; IL1_HBGF; 1.

Pfam

PF00167; FGF; 1.
Pfam graphical view of domain structure.

PRINTS

PR00263; HBGFFGF.
PR00262; IL1HBGF.

ProDom

PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00442; FGF; 1.
SMART graphical view of domain structure.

PROSITE

PS00247; HBGF_FGF; 1.

BLOCKS

Q9NP95.

Genome annotation databases

Ensembl

ENSG00000078579; Homo sapiens. [Contig view]

GeneID

26281; -.

KEGG

hsa:26281; -.

Phylogenomic databases

HOGENOM

Q9NP95; -.

HOVERGEN

Q9NP95; -.

Other

FGF20; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Growth factor; Polymorphism; Secreted.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 211`	`211`	`Fibroblast growth factor 20.`	`PRO_0000147616`
`VARIANT`	`116 116`	`1`	`G -> R (in dbSNP:rs3793405 [NCBI]).`	`VAR_020946`
`VARIANT`	`175 175`	`1`	`P -> A (in dbSNP:rs10089600 [NCBI]).`	`VAR_020947`
`VARIANT`	`206 206`	`1`	`D -> N (in dbSNP:rs17550360 [NCBI]).`	`VAR_020948`

Sequence information

Length: 211 AA [This is the length of the unprocessed precursor]

Molecular weight: 23499 Da [This is the MW of the unprocessed precursor]

CRC64: AB04608C16060CC1 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL 

        70         80         90        100        110        120 
HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG 

       130        140        150        160        170        180 
MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR 

       190        200        210 
SKRHQKFTHF LPRPVDPERV PELYKDLLMY T

Q9NP95 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools