[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). DOI=10.1006/geno.1999.5979; PubMed=10585776 [NCBI, ExPASy, EBI, Israel, Japan] Hu S., Tamada K., Ni J., Vincenz C., Chen L.; "Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily."; Genomics 62:103-107(1999).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). TISSUE=Embryo, and Spleen; DOI=10.1074/jbc.275.20.15336; PubMed=10809768 [NCBI, ExPASy, EBI, Israel, Japan] Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.; "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."; J. Biol. Chem. 275:15336-15342(2000).
[3]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). TISSUE=Brain; DOI=10.1074/jbc.M002691200; PubMed=10764796 [NCBI, ExPASy, EBI, Israel, Japan] Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T.; "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles."; J. Biol. Chem. 275:20742-20747(2000).
[4]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). STRAIN=C57BL/6; Chaudhary D., Long A.J.; "TRADE, a novel TNF receptor family member associated with death signaling."; Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[5]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). STRAIN=Czech II; TISSUE=Lung; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors.
SUBUNIT: Associates with TRAF1, TRAF2, TRAF3 and TRAF5 (By similarity). Interacts with LINGO1 (By similarity).
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable).
SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein (Probable).
SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type I membrane protein (Probable).
SUBCELLULAR LOCATION: Isoform 2: Secreted (Probable).

ALTERNATIVE PRODUCTS: 4 named isoforms [FASTA] produced by alternative splicing.

Name	1
Synonyms	TAJ-alphaL
Isoform ID	Q9JLL3-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	TAJ-beta1
Isoform ID	Q9JLL3-2
Features which should be applied to build the isoform sequence: VSP_006513, VSP_006514.

Name	3
Synonyms	TAJ-alphaS, dTROY
Isoform ID	Q9JLL3-3
Features which should be applied to build the isoform sequence: VSP_006515, VSP_006516.

Name	4
Isoform ID	Q9JLL3-4
Features which should be applied to build the isoform sequence: VSP_006517, VSP_006518.

TISSUE SPECIFICITY: Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver.
SIMILARITY: Contains 3 TNFR-Cys repeats.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF173166; AAF19795.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF167552; AAF71825.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF167554; AAF71827.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF167553; AAF71826.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB040432; BAB03267.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB040433; BAB03268.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF247000; AAK28397.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030062; AAH30062.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00340474; -.
IPI00387198; -.
IPI00387201; -.
IPI00399493; -.

UniGene

Mm.281356

3D structure databases

HSSP

Q92956; 1JMA. [HSSP ENTRY / PDB]

ModBase

Q9JLL3.

Organism-specific databases

MGI

MGI:1352474; Tnfrsf19.

Gene expression databases

ArrayExpress

Q9JLL3; -.

Bgee

Q9JLL3; -.

GermOnline

ENSMUSG00000060548; Mus musculus.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004872;	Molecular function: receptor activity (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001368; TNFR_Cys_rich_reg.
Graphical view of domain structure.

Pfam

PF00020; TNFR_c6; 1.
Pfam graphical view of domain structure.

SMART

SM00208; TNFR; 2.
SMART graphical view of domain structure.

PROSITE

PS00652; TNFR_NGFR_1; 2.
PS50050; TNFR_NGFR_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSMUSG00000060548; Mus musculus. [Contig view]

Phylogenomic databases

HOGENOM

Q9JLL3; -.

HOVERGEN

Q9JLL3; -.

Other

SOURCE

Tnfrsf19; Mus musculus.

ProtoNet

Q9JLL3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein; Membrane; Receptor; Repeat; Secreted; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 29`	`29`	`Potential.`
`CHAIN`	`30 416`	`387`	`Tumor necrosis factor receptor superfamily member 19.`	`PRO_0000034598`
`TOPO_DOM`	`30 170`	`141`	`Extracellular (Potential).`
`TRANSMEM`	`171 191`	`21`	`Potential.`
`TOPO_DOM`	`192 416`	`225`	`Cytoplasmic (Potential).`
`REPEAT`	`33 72`	`40`	`TNFR-Cys 1.`
`REPEAT`	`74 114`	`41`	`TNFR-Cys 2.`
`REPEAT`	`116 149`	`34`	`TNFR-Cys 3; truncated.`
`CARBOHYD`	`105 105`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`34 46`		`By similarity.`
`DISULFID`	`49 62`		`By similarity.`
`DISULFID`	`52 72`		`By similarity.`
`DISULFID`	`75 89`		`By similarity.`
`DISULFID`	`92 106`		`By similarity.`
`DISULFID`	`95 114`		`By similarity.`
`DISULFID`	`117 135`		`By similarity.`
`DISULFID`	`138 149`		`By similarity.`
`VAR_SEQ`	`150 150`		`T -> E (in isoform 2).`	`VSP_006513`
`VAR_SEQ`	`151 416`		`Missing (in isoform 2).`	`VSP_006514`
`VAR_SEQ`	`204 214`		`WSLRSQDIQYN -> CKLPSLCLTVK (in isoform 3).`	`VSP_006515`
`VAR_SEQ`	`215 416`		`Missing (in isoform 3).`	`VSP_006516`
`VAR_SEQ`	`340 348`		`NESTASLDS -> MLCFRFRDL (in isoform 4).`	`VSP_006517`
`VAR_SEQ`	`349 416`		`Missing (in isoform 4).`	`VSP_006518`
`CONFLICT`	`31 31`		`T -> A (in Ref. 1; AAF19795).`
`CONFLICT`	`208 208`		`S -> P (in Ref. 1; AAF19795).`
`CONFLICT`	`287 287`		`N -> D (in Ref. 3; BAB03267/AAK28397).`
`CONFLICT`	`343 343`		`T -> A (in Ref. 3; BAB03267/AAK28397).`

Sequence information

Length: 416 AA [This is the length of the unprocessed precursor]

Molecular weight: 45294 Da [This is the MW of the unprocessed precursor]

CRC64: 19CA2F75DD7B9D49 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALKVLPLHR TVLFAAILFL LHLACKVSCE TGDCRQQEFK DRSGNCVLCK QCGPGMELSK 

        70         80         90        100        110        120 
ECGFGYGEDA QCVPCRPHRF KEDWGFQKCK PCADCALVNR FQRANCSHTS DAVCGDCLPG 

       130        140        150        160        170        180 
FYRKTKLVGF QDMECVPCGD PPPPYEPHCT SKVNLVKISS TVSSPRDTAL AAVICSALAT 

       190        200        210        220        230        240 
VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDQPRLRHCA HRACCQYHRD 

       250        260        270        280        290        300 
SAPMYGPVHL IPSLCCEEAR SSARAVLGCG LRSPTTLQER NPASVGNTMP AFFGSVSRSI 

       310        320        330        340        350        360 
CAEFSDAWPL MQNPLGGDSS LCDSYPELTG EDTNSLNPEN ESTASLDSSG GQDLAGTAAL 

       370        380        390        400        410 
ESSGNVSEST DSPRHGDTGT VWEQTLAQDA QRTPSQGGWE DRENLNLAMP TAFQDA

Q9JLL3 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools