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UniProtKB/Swiss-Prot entry Q9JI85

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUCB2_RAT
Primary accession number Q9JI85
Secondary accession numbers None
Integrated into Swiss-Prot on November 2, 2001
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 48)
Name and origin of the protein
Protein name Nucleobindin-2 [Precursor]
Synonym DNA-binding protein NEFA
Gene name
Name: Nucb2
Synonyms: Nefa
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Ovary;
Hirschfeld G., Heiden I., Barnikol-Watanabe S., Barnikol H.U., Hilschmann N.;
"Rat NEFA mRNA.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
Hauge X., Neve K.A.;
"Characterization of rat NEFA protein.";
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF250142; AAF75993.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF238223; AAK66864.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC061778; AAH61778.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_067695.1; -.
UniGene Rn.41602
3D structure databases
SMR Q9JI85; 229-327.
ModBase Q9JI85.
Protein-protein interaction databases
IntAct Q9JI85; -.
Organism-specific databases
RGD 620888; Nucb2.
Gene expression databases
ArrayExpress Q9JI85; -.
GermOnline ENSRNOG00000020456; Rattus norvegicus.
Family and domain databases
InterPro IPR011992; EF-Hand_type.
IPR002048; EF_hand_Ca_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.238.10; EF-Hand_type; 1.
Pfam PF00036; efhand; 2.
Pfam graphical view of domain structure.
SMART SM00054; EFh; 2.
SMART graphical view of domain structure.
PROSITE PS00018; EF_HAND_1; 2.
PS50222; EF_HAND_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9JI85.
Genome annotation databases
Ensembl ENSRNOG00000020456; Rattus norvegicus. [Contig view]
GeneID 59295; -.
KEGG rno:59295; -.
Phylogenomic databases
HOVERGEN Q9JI85; -.
Other
ProtoNet Q9JI85.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Cytoplasm; DNA-binding; Membrane; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    24  24     Potential. 
CHAIN   25   420  396     Nucleobindin-2. PRO_0000004167
DOMAIN   241   276  36     EF-hand 1. 
DOMAIN   293   328  36     EF-hand 2. 
DNA_BIND   171   223  53     By similarity. 
CA_BIND   254   265  12     1. 
CA_BIND   306   317  12     2. 
REGION   213   420  208     Binds to necdin (By similarity). 
COMPBIAS   284   293  10     Asp/Glu-rich (acidic). 
CONFLICT   38    38        E -> D (in Ref. 2; AAK66864). 
CONFLICT   352   352        S -> G (in Ref. 2; AAK66864). 
Sequence information
Length: 420 AA [This is the length of the unprocessed precursor] Molecular weight: 50090 Da [This is the MW of the unprocessed precursor] CRC64: E7684E6C835F98FB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRWRTIQARY CFLLVPCVLT ALEAVPIDVD KTKVHNVEPV ESARIEPPDT GLYYDEYLKQ 

        70         80         90        100        110        120 
VIEVLETDPH FREKLQKADI EEIRSGRLSQ ELDLVSHKVR TRLDELKRQE VGRLRMLIKA 

       130        140        150        160        170        180 
KLDALQDTGM NHHLLLKQFE HLNHQNPDTF ESKDLDMLIK AATADLEQYD RTRHEEFKKY 

       190        200        210        220        230        240 
EMMKEHERRE YLKTLSEEKR KEEEAKFAEM KRKHEDHPKV NHPGSKDQLK EVWEETDGLD 

       250        260        270        280        290        300 
PNDFDPKTFF KLHDVNNDGF LDEQELEALF TKELDKVYNP QNAEDDMIEM EEERLRMREH 

       310        320        330        340        350        360 
VMNEIDNNKD RLVTLEEFLR ATEKKEFLEP DSWETLDQQQ LFTEEELKEY ESIIAIQESE 

       370        380        390        400        410        420 
LKKKADELQK QKEELQRQHD HLEAQKQEYQ QAVQQLEQKK FQQGIAPSGP AGELKFEPHT
Q9JI85 in FASTA format

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