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UniProtKB/Swiss-Prot entry Q9H0Y0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATG10_HUMAN
Primary accession number Q9H0Y0
Secondary accession numbers B2RE09 Q6PIX1 Q9H842
Integrated into Swiss-Prot on March 29, 2005
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 56)
Name and origin of the protein
Protein name Autophagy-related protein 10
Synonym APG10-like
Gene name
Name: ATG10
ORFNames: PP12616, APG10L
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
DOI=10.1073/pnas.0404089101; PubMed=15498874 [NCBI, ExPASy, EBI, Israel, Japan]
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X., Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
"Large-scale cDNA transfection screening for genes related to cancer development and progression.";
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Thymus;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Uterus;
DOI=10.1186/1471-2164-8-399; PubMed=17974005 [NCBI, ExPASy, EBI, Israel, Japan]
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS MET-212 AND HIS-220.
TISSUE=Placenta, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF318326; AAL55833.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK024016; BAB14778.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK315752; BAG38106.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136912; CAB66846.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC004551; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
BC027718; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
BC029268; AAH29268.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00017456; -.
IPI00073313; -.
RefSeq NP_001124500.1; -.
NP_113670.1; -.
UniGene Hs.713698
3D structure databases
ModBase Q9H0Y0.
Protein-protein interaction databases
IntAct Q9H0Y0; 1.
Organism-specific databases
GeneCards GC05P081304; -.
HGNC HGNC:20315; ATG10.
GenAtlas ATG10.
MIM 610800; gene. [NCBI / EBI]
PharmGKB PA134872167; -.
Gene expression databases
ArrayExpress Q9H0Y0; -.
Bgee Q9H0Y0; -.
CleanEx HS_ATG10; -.
GermOnline ENSG00000152348; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0034263; Biological process: autophagy in response to ER overload (inferred from mutant phenotype from UniProtKB).
GO:0019941; Biological process: modification-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0031401; Biological process: positive regulation of protein modification process (inferred from sequence or structural similarity from UniProtKB).
GO:0006497; Biological process: protein amino acid lipidation (inferred from sequence or structural similarity from UniProtKB).
GO:0032446; Biological process: protein modification by small protein conjugation (inferred from direct assay from UniProtKB).
GO:0015031; Biological process: protein transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR007135; Autophagy-rel_prot_3.
Graphical view of domain structure.
Pfam PF03987; Autophagy_act_C; 1.
Pfam graphical view of domain structure.
Genome annotation databases
Ensembl ENSG00000152348; Homo sapiens. [Contig view]
GeneID 83734; -.
KEGG hsa:83734; -.
Phylogenomic databases
HOGENOM Q9H0Y0; -.
HOVERGEN Q9H0Y0; -.
OMA Q9H0Y0; SPLHLAN.
Other
NextBio 72737; -.
SOURCE ATG10; Homo sapiens.
ProtoNet Q9H0Y0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Autophagy; Cytoplasm; Polymorphism; Protein transport; Transport; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   220  220     Autophagy-related protein 10. PRO_0000096183
VAR_SEQ   73   125        EAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLY FRASFLDGRPLTL -> VKSCSVTQAGVQLRDLSSLQPPPSGFKQFSCLSLPSNWDY RGSPLHLANFLYF (in isoform 2). VSP_013272
VAR_SEQ   126   220        Missing (in isoform 2). VSP_013273
VARIANT   62    62  1     S -> P (in dbSNP:rs3734114 [NCBI]). VAR_024370 
VARIANT   212   212  1     T -> M (in dbSNP:rs1864183 [NCBI]). VAR_021562 
VARIANT   220   220  1     P -> H (in dbSNP:rs1864182 [NCBI]). VAR_021563 
Sequence information
Length: 220 AA [This is the length of the unprocessed precursor] Molecular weight: 25279 Da [This is the MW of the unprocessed precursor] CRC64: 1EDA80E385779B69 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI KNGSVMSHLG 

        70         80         90        100        110        120 
ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV LYSCSYQVPV LYFRASFLDG 

       130        140        150        160        170        180 
RPLTLKDIWE GVHECYKMRL LQGPWDTITQ QEHPILGQPF FVLHPCKTNE FMTPVLKNSQ 

       190        200        210        220 
KINKNVNYIT SWLSIVGPVV GLNLPLSYAK ATSQDERNVP 

Q9H0Y0 in FASTA format

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