[1]	NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS PHE-241 AND ASP-269. DOI=10.1038/79124; PubMed=10973240 [NCBI, ExPASy, EBI, Israel, Japan] Rodriguez I., Greer C.A., Mok M.Y., Mombaerts P.; "A putative pheromone receptor gene expressed in human olfactory mucosa."; Nat. Genet. 26:18-19(2000).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. Holloway J., Lofton-Day C., Lok S.; "Human pheromone receptor ortholog subtype I member 1."; Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-139; PHE-241 AND ASP-269. DOI=10.1073/pnas.1331721100; PubMed=12826614 [NCBI, ExPASy, EBI, Israel, Japan] Zhang J., Webb D.M.; "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."; Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1016/S0014-5793(02)02775-8; PubMed=12044878 [NCBI, ExPASy, EBI, Israel, Japan] Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; "Identification of G protein-coupled receptor genes from the human genome sequence."; FEBS Lett. 520:97-101(2002).
[5]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Putative pheromone receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in the olfactory mucosa, very low expression in brain, lung and kidney.
MISCELLANEOUS: The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].
WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of August 2005; URL="http://www.expasy.org/spotlight/back_issues/sptlt061.shtml";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF255342; AAG10698.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF302903; AAG22545.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY312477; AAP85612.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY312478; AAP85613.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY312479; AAP85614.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB083606; BAB89319.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC095508; AAH95508.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00009853; -.

NP_065684.1; -.

3D structure databases

ModBase

Q9GZP7.

Protein family/group databases

GPCRDB

Q9GZP7; VN1R1_HUMAN.

Organism-specific databases

GC19M062658; -.

HGNC:13548; VN1R1.

605234; gene. [NCBI / EBI]

PharmGKB

PA134957891; -.

Gene expression databases

Q9GZP7; -.

Q9GZP7; -.

HS_VN1R1; -.

ENSG00000178201; Homo sapiens.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016503;	Molecular function: pheromone receptor activity (inferred from electronic annotation from InterPro).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0019236;	Biological process: response to pheromone (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
IPR004072; Vmron_rcpt_1.
Graphical view of domain structure.

PANTHER

PTHR11391; Vmron_rcpt_1; 1.

Pfam

PF03402; V1R; 1.
Pfam graphical view of domain structure.

PRINTS

PR01534; VOMERONASL1R.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9GZP7; -.

Genome annotation databases

Ensembl

ENSG00000178201; Homo sapiens. [Contig view]

GeneID

57191; -.

KEGG

hsa:57191; -.

Phylogenomic databases

HOGENOM

Q9GZP7; -.

HOVERGEN

Q9GZP7; -.

OMA

Q9GZP7; YFSPDFM.

Other

63274; -.

VN1R1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Pheromone response; Polymorphism; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 353`	`353`	`Vomeronasal type-1 receptor 1.`	`PRO_0000070213`
`TOPO_DOM`	`1 56`	`56`	`Extracellular (Potential).`
`TRANSMEM`	`57 77`	`21`	`1 (Potential).`
`TOPO_DOM`	`78 84`	`7`	`Cytoplasmic (Potential).`
`TRANSMEM`	`85 105`	`21`	`2 (Potential).`
`TOPO_DOM`	`106 132`	`27`	`Extracellular (Potential).`
`TRANSMEM`	`133 153`	`21`	`3 (Potential).`
`TOPO_DOM`	`154 169`	`16`	`Cytoplasmic (Potential).`
`TRANSMEM`	`170 190`	`21`	`4 (Potential).`
`TOPO_DOM`	`191 226`	`36`	`Extracellular (Potential).`
`TRANSMEM`	`227 247`	`21`	`5 (Potential).`
`TOPO_DOM`	`248 274`	`27`	`Cytoplasmic (Potential).`
`TRANSMEM`	`275 295`	`21`	`6 (Potential).`
`TOPO_DOM`	`296 303`	`8`	`Extracellular (Potential).`
`TRANSMEM`	`304 324`	`21`	`7 (Potential).`
`TOPO_DOM`	`325 353`	`29`	`Cytoplasmic (Potential).`
`CARBOHYD`	`117 117`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`198 198`		`N-linked (GlcNAc...) (Potential).`
`VARIANT`	`103 103`	`1`	`I -> M (in dbSNP:rs3746223 [NCBI]).`	`VAR_049452`
`VARIANT`	`139 139`	`1`	`I -> T (in allele VN1R1*2).`	`VAR_022795`
`VARIANT`	`241 241`	`1`	`S -> F (in allele VN1R1*3).`	`VAR_022796`
`VARIANT`	`269 269`	`1`	`A -> D (in allele VN1R1*3).`	`VAR_022797`

Sequence information

Length: 353 AA [This is the length of the unprocessed precursor]

Molecular weight: 40021 Da [This is the MW of the unprocessed precursor]

CRC64: CCB0E9BAFA5EC021 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI SFLIQTGVGI 

        70         80         90        100        110        120 
LGNSFLLCFY NLILFTGHKL RPTDLILSQL ALANSMVLFF KGIPQTMAAF GLKYLLNDTG 

       130        140        150        160        170        180 
CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL NPSICRWMEI KIRSPRFIDF CCLLCWAPHV 

       190        200        210        220        230        240 
LMNASVLLLV NGPLNSKNSS AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG 

       250        260        270        280        290        300 
SMVFFLYRHK QQVQHNHSNR LSCRPSQEAR ATHTIMVLVS SFFVFYSVHS FLTIWTTVVA 

       310        320        330        340        350 
NPGQWIVTNS VLVASCFPAR SPFVLIMSDT HISQFCFACR TRKTLFPNLV VMP

Q9GZP7 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools