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UniProtKB/Swiss-Prot entry Q9ERZ8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TRPV4_RAT
Primary accession number Q9ERZ8
Secondary accession numbers None
Integrated into Swiss-Prot on April 26, 2005
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 52)
Name and origin of the protein
Protein name Transient receptor potential cation channel subfamily V member 4
Synonyms TrpV4
Osm-9-like TRP channel 4
OTRPC4
Vanilloid receptor-related osmotically-activated channel
VR-OAC
Gene name
Name: Trpv4
Synonyms: Vroac
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Kidney;
DOI=10.1016/S0092-8674(00)00143-4; PubMed=11081638 [NCBI, ExPASy, EBI, Israel, Japan]
Liedtke W.B., Choe Y., Marti-Renom M.A., Bell A.M., Denis C.S., Sali A., Hudspeth A.J., Friedman J.M., Heller S.;
"Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.";
Cell 103:525-535(2000).
Comments
  • FUNCTION: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity).
  • SUBUNIT: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES (By similarity).
  • SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
  • TISSUE SPECIFICITY: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia.
  • SIMILARITY: Belongs to the transient receptor family. TrpV subfamily.
  • SIMILARITY: Contains 3 ANK repeats.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF263521; AAG28027.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00191593; -.
RefSeq NP_076460.1; -.
UniGene Rn.64508
3D structure databases
ModBase Q9ERZ8.
Protein family/group databases
TCDB 1.A.4.2.5; transient receptor potential Ca2+ channel (TRP-CC) family.
Organism-specific databases
RGD 69337; Trpv4.
Gene expression databases
ArrayExpress Q9ERZ8; -.
GermOnline ENSRNOG00000001195; Rattus norvegicus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from sequence or structural similarity from UniProtKB).
GO:0005262; Molecular function: calcium channel activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005516; Molecular function: calmodulin binding (inferred from sequence or structural similarity from UniProtKB).
GO:0006816; Biological process: calcium ion transport (inferred from electronic annotation from UniProtKB-KW).
GO:0006874; Biological process: cellular calcium ion homeostasis (inferred from sequence or structural similarity from UniProtKB).
GO:0006971; Biological process: hypotonic response (inferred from direct assay from RGD).
QuickGo view.
Family and domain databases
InterPro IPR002110; ANK.
IPR005821; Ion_trans.
IPR004729; TRP_channel.
IPR008347; Vanilpoid_rcpt.
IPR008348; Vanilpoid_rcpt_2.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.20; ANK; 1.
Pfam PF00023; Ank; 3.
PF00520; Ion_trans; 1.
Pfam graphical view of domain structure.
PRINTS PR01768; TRPVRECEPTOR.
PR01769; VRL2RECEPTOR.
SMART SM00248; ANK; 3.
SMART graphical view of domain structure.
TIGRFAMs TIGR00870; trp; 1.
PROSITE PS50297; ANK_REP_REGION; 1.
PS50088; ANK_REPEAT; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSRNOG00000001195; Rattus norvegicus. [Contig view]
GeneID 66026; -.
KEGG rno:66026; -.
Phylogenomic databases
HOVERGEN Q9ERZ8; -.
OMA Q9ERZ8; QPPPILK.
Other
NextBio 614333; -.
ProtoNet Q9ERZ8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ANK repeat; Calcium; Calcium channel; Calcium transport; Calmodulin-binding; Ion transport; Ionic channel; Membrane; Phosphoprotein; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   871  871     Transient receptor potential cation channel subfamily V member 4. PRO_0000215349
TOPO_DOM   1   465  465     Cytoplasmic (Potential). 
TRANSMEM   466   486  21     Potential. 
TOPO_DOM   487   508  22     Extracellular (Potential). 
TRANSMEM   509   529  21     Potential. 
TOPO_DOM   530   550  21     Cytoplasmic (Potential). 
TRANSMEM   551   571  21     Potential. 
TOPO_DOM   572   572  1     Extracellular (Potential). 
TRANSMEM   573   593  21     Potential. 
TOPO_DOM   594   616  23     Cytoplasmic (Potential). 
TRANSMEM   617   637  21     Potential. 
TOPO_DOM   638   690  53     Pore forming (Probable). 
TRANSMEM   691   711  21     Potential. 
TOPO_DOM   712   871  160     Cytoplasmic (Potential). 
REPEAT   237   266  30     ANK 1. 
REPEAT   284   313  30     ANK 2. 
REPEAT   369   398  30     ANK 3. 
REGION   812   831  20     Interaction with calmodulin (By similarity). 
MOD_RES   253   253        Phosphotyrosine (By similarity). 
Sequence information
Length: 871 AA [This is the length of the unprocessed precursor] Molecular weight: 98010 Da [This is the MW of the unprocessed precursor] CRC64: 5D50684DA08C354B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MADPGDGPRA APGDVAEPPG DESGTSGGEA FPLSSLANLF EGEEGSSSLS PVDASRPAGP 

        70         80         90        100        110        120 
GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHPSDN 

       130        140        150        160        170        180 
KRWRRKVVEK QPQSPKAPAP QPPPILKVFN RPILFDIVSR GSTADLDGLL SYLLTHKKRL 

       190        200        210        220        230        240 
TDEEFREPST GKTCLPKALL NLSNGRNDTI PVLLDIAERT GNMREFINSP FRDIYYRGQT 

       250        260        270        280        290        300 
ALHIAIERRC KHYVELLVAQ GADVHAQARG RFFQPKDEGG YFYFGELPLS LAACTNQPHI 

       310        320        330        340        350        360 
VNYLTENPHK KADMRRQDSR GNTVLHALVA IADNTRENTK FVTKMYDLLL LKCSRLFPDS 

       370        380        390        400        410        420 
NLETVLNNDG LSPLMMAAKT GKIGVFQHII RREVTDEDTR HLSRKFKDWA YGPVYSSLYD 

       430        440        450        460        470        480 
LSSLDTCGEE VSVLEILVYN SKIENRHEML AVEPINELLR DKWRKFGAVS FYINVVSYLC 

       490        500        510        520        530        540 
AMVIFTLTAY YQPLEGTPPY PYRTTVDYLR LAGEVITLLT GVLFFFTSIK DLFMKKCPGV 

       550        560        570        580        590        600 
NSLFVDGSFQ LLYFIYSVLV VVSAALYLAG IEAYLAVMVF ALVLGWMNAL YFTRGLKLTG 

       610        620        630        640        650        660 
TYSIMIQKIL FKDLFRFLLV YLLFMIGYAS ALVTLLNPCT NMKVCNEDQS NCTVPSYPAC 

       670        680        690        700        710        720 
RDSETFSAFL LDLFKLTIGM GDLEMLSSAK YPVVFILLLV TYIILTFVLL LNMLIALMGE 

       730        740        750        760        770        780 
TVGQVSKESK HIWKLQWATT ILDIERSFPV FLRKAFRSGE MVTVGKSSDG TPDRRWCFRV 

       790        800        810        820        830        840 
DEVNWSHWNQ NLGIINEDPG KSEIYQYYGF SHTMGRLRRD RWSSVVPRVV ELNKNSGTDE 

       850        860        870 
VVVPLDNLGN PNCDGHQQGY APKWRAEDAP L
Q9ERZ8 in FASTA format

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