[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=129/SvJ; DOI=10.1101/gr.10.12.1958; PubMed=11116090 [NCBI, ExPASy, EBI, Israel, Japan] Del Punta K., Rothman A., Rodriguez I., Mombaerts P.; "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse."; Genome Res. 10:1958-1967(2000).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Sam M., Matsunami H., Buck L.; "Vomeronasal receptor gene diversity in the mammalian genome."; Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[3]	PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE. DOI=10.1038/nature00955; PubMed=12214233 [NCBI, ExPASy, EBI, Israel, Japan] Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.; "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes."; Nature 419:70-74(2002).

Comments

FUNCTION: Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential).
DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF291482; AAG42076.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB062894; BAB79212.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00110398; -.

NP_444448.1; -.

3D structure databases

ModBase

Q9EQ52.

Protein family/group databases

GPCRDB

Q9EQ52; VN1A3_MOUSE.

Organism-specific databases

MGI

MGI:2148508; V1ra3.

Gene expression databases

CleanEx

MM_V1RA3; -.
MM_V1RA6; -.

GermOnline

ENSMUSG00000057592; Mus musculus.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016503;	Molecular function: pheromone receptor activity (inferred from electronic annotation from InterPro).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0019236;	Biological process: response to pheromone (inferred from electronic annotation from UniProtKB-KW).
GO:0007606;	Biological process: sensory perception of chemical stimulus (traceable author statement from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
IPR004072; Vmron_rcpt_1.
Graphical view of domain structure.

PANTHER

PTHR11391; Vmron_rcpt_1; 1.

Pfam

PF03402; V1R; 1.
Pfam graphical view of domain structure.

PRINTS

PR01534; VOMERONASL1R.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9EQ52; -.

Genome annotation databases

Ensembl

ENSMUSG00000057592; Mus musculus. [Contig view]

GeneID

113845; -.

KEGG

mmu:113845; -.

Phylogenomic databases

HOVERGEN

Q9EQ52; -.

OMA

Q9EQ52; ISTEKHI.

Other

367959; -.

V1ra3; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Pheromone response; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 302`	`302`	`Vomeronasal type-1 receptor A3.`	`PRO_0000239958`
`TOPO_DOM`	`1 16`	`16`	`Extracellular (Potential).`
`TRANSMEM`	`17 37`	`21`	`1 (Potential).`
`TOPO_DOM`	`38 49`	`12`	`Cytoplasmic (Potential).`
`TRANSMEM`	`50 70`	`21`	`2 (Potential).`
`TOPO_DOM`	`71 91`	`21`	`Extracellular (Potential).`
`TRANSMEM`	`92 114`	`23`	`3 (Potential).`
`TOPO_DOM`	`115 131`	`17`	`Cytoplasmic (Potential).`
`TRANSMEM`	`132 152`	`21`	`4 (Potential).`
`TOPO_DOM`	`153 193`	`41`	`Extracellular (Potential).`
`TRANSMEM`	`194 214`	`21`	`5 (Potential).`
`TOPO_DOM`	`215 238`	`24`	`Cytoplasmic (Potential).`
`TRANSMEM`	`239 259`	`21`	`6 (Potential).`
`TOPO_DOM`	`260 269`	`10`	`Extracellular (Potential).`
`TRANSMEM`	`270 290`	`21`	`7 (Potential).`
`TOPO_DOM`	`291 302`	`12`	`Cytoplasmic (Potential).`
`CARBOHYD`	`159 159`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`85 172`		`By similarity.`

Sequence information

Length: 302 AA [This is the length of the unprocessed precursor]

Molecular weight: 34263 Da [This is the MW of the unprocessed precursor]

CRC64: EC0CB056AD9F9F0D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL PIGLLSLIHL 

        70         80         90        100        110        120 
LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL CTTSMLSVLQ AIILSPRSYC 

       130        140        150        160        170        180 
LAKFKRKSSH NISCAIIFLS VLYMSISSHL LISITATPNL TMNDFLYVSQ SCSLLPLSYL 

       190        200        210        220        230        240 
MQSIYSTLLV LREVFLIGLM VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI 

       250        260        270        280        290        300 
LMLMTFFVLM SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL 


RG

Q9EQ52 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools