[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Hypothalamus;
DOI=10.1016/S0092-8674(00)00143-4; PubMed=11081638 [NCBI, ExPASy, EBI, Israel, Japan]
Liedtke W.B.,
Choe Y.,
Marti-Renom M.A.,
Bell A.M.,
Denis C.S.,
Sali A.,
Hudspeth A.J.,
Friedman J.M.,
Heller S.;
"Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.";
Cell 103:525-535(2000).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Kidney;
DOI=10.1016/S0014-5793(00)02212-2; PubMed=11094154 [NCBI, ExPASy, EBI, Israel, Japan]
Wissenbach U.,
Boedding M.,
Freichel M.,
Flockerzi V.;
"Trp12, a novel Trp related protein from kidney.";
FEBS Lett. 485:127-134(2000).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=129/SvEv;
DOI=10.1038/35036318; PubMed=11025659 [NCBI, ExPASy, EBI, Israel, Japan]
Strotmann R.,
Harteneck C.,
Nunnenmacher K.,
Schultz G.,
Plant T.D.;
"OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity.";
Nat. Cell Biol. 2:695-702(2000).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Kidney;
DOI=10.1074/jbc.M302561200; PubMed=12692122 [NCBI, ExPASy, EBI, Israel, Japan]
Suzuki M.,
Mizuno A.,
Kodaira K.,
Imai M.;
"Impaired pressure sensation in mice lacking TRPV4.";
J. Biol. Chem. 278:22664-22668(2003).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
Derst C.,
Schafer M.K.;
"Cloning of mouse and human vanilloid receptor-like protein 2 (VRL-2).";
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
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[6]
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CHARACTERIZATION OF CHANNEL PORE, AND MUTAGENESIS OF ASP-672; LYS-675; MET-680 AND ASP-682.
DOI=10.1074/jbc.M204828200; PubMed=12093812 [NCBI, ExPASy, EBI, Israel, Japan]
Voets T.,
Prenen J.,
Vriens J.,
Watanabe H.,
Janssens A.,
Wissenbach U.,
Bodding M.,
Droogmans G.,
Nilius B.;
"Molecular determinants of permeation through the cation channel TRPV4.";
J. Biol. Chem. 277:33704-33710(2002).
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[7]
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INTERACTION WITH MAP7.
DOI=10.1074/jbc.M308212200; PubMed=14517216 [NCBI, ExPASy, EBI, Israel, Japan]
Suzuki M.,
Hirao A.,
Mizuno A.;
"Microtubule-associated protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).";
J. Biol. Chem. 278:51448-51453(2003).
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[8]
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INTERACTION WITH LYN; SRC; FYN; HCK; LCK AND YES, PHOSPHORYLATION AT TYR-253, AND MUTAGENESIS OF TYR-253.
DOI=10.1074/jbc.M211061200; PubMed=12538589 [NCBI, ExPASy, EBI, Israel, Japan]
Xu H.,
Zhao H.,
Tian W.,
Yoshida K.,
Roullet J.B.,
Cohen D.M.;
"Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.";
J. Biol. Chem. 278:11520-11527(2003).
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- FUNCTION: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.
- SUBUNIT: Interacts with calmodulin (By similarity). Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.
- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
- TISSUE SPECIFICITY: Expressed heart, liver, kidney and testis. In the central nervous system, expressed in the lamina terminalis (arched vascular organ and neurons of the subfornical organ), median preoptic area, ventral hippocampal commissure, and ependymal cells of the choroid plexus. In the cochlea, expressed in both inner and outer hair cells, and in marginal cells of the cochlear stria vascularis. Expressed in large neurons of the trigeminal ganglion. In the kidney cortex, strongly expressed by epithelial cells of tubules and much weaker in glomeruli.
- SIMILARITY: Belongs to the transient receptor family. TrpV subfamily.
- SIMILARITY: Contains 3 ANK repeats.
- SEQUENCE CAUTION:
- Sequence=AAG28028.1; Type=Frameshift; Positions=47, 50, 53, 72, 73;
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