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UniProtKB/Swiss-Prot entry Q9C5U8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_ARATH
Primary accession number Q9C5U8
Secondary accession numbers Q8LA77 Q9FN00
Integrated into Swiss-Prot on March 28, 2003
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 56)
Name and origin of the protein
Protein name Histidinol dehydrogenase, chloroplastic [Precursor]
Synonyms HDH
EC 1.1.1.23
Gene name
Name: HDH
OrderedLocusNames: At5g63890
ORFNames: MGI19.9
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Fujimori K.;
"Isolation of Arabidopsis cDNA for histidinol dehydrogenase.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1093/dnares/4.6.401; PubMed=9501997 [NCBI, ExPASy, EBI, Israel, Japan]
Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence features of the regions of 1,191,918 bp covered by seventeen physically assigned P1 clones.";
DNA Res. 4:401-414(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB027709; BAB40445.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB007646; BAB11037.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY039881; AAK63985.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY143900; AAN28839.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY087987; AAM65533.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_568981.2; -.
UniGene At.20645
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase Q9C5U8.
Organism-specific databases
TAIR At5g63890; -.
Gene expression databases
ArrayExpress Q9C5U8; -.
GermOnline AT5G63890; Arabidopsis thaliana.
Ontologies
GO
GO:0009507; Cellular component: chloroplast (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q9C5U8.
ProtoNet Q9C5U8.
Genome annotation databases
GeneID 836509; -.
GenomeReviews BA000015_GR; AT5G63890.
KEGG ath:AT5G63890; -.
NMPDR fig|3702.1.peg.28443; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Amino-acid biosynthesis; Chloroplast; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Plastid; Transit peptide; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    30  30     Chloroplast (By similarity). 
CHAIN   31   466  436     Histidinol dehydrogenase, chloroplastic. PRO_0000007215
ACT_SITE   356   356        Proton acceptor (By similarity). 
ACT_SITE   357   357        Proton acceptor (By similarity). 
METAL   288   288        Zinc (By similarity). 
METAL   291   291        Zinc (By similarity). 
METAL   390   390        Zinc (By similarity). 
METAL   449   449        Zinc (By similarity). 
BINDING   155   155        NAD (By similarity). 
BINDING   217   217        NAD (By similarity). 
BINDING   240   240        NAD (By similarity). 
BINDING   266   266        Substrate (By similarity). 
BINDING   288   288        Substrate (By similarity). 
BINDING   291   291        Substrate (By similarity). 
BINDING   357   357        Substrate (By similarity). 
BINDING   390   390        Substrate (By similarity). 
BINDING   444   444        Substrate (By similarity). 
BINDING   449   449        Substrate (By similarity). 
VAR_SEQ   1    31        Missing (in isoform 2). VSP_008912
CONFLICT   25    25        K -> KA (in Ref. 2; BAB11037). 
Sequence information
Length: 466 AA [This is the length of the unprocessed precursor] Molecular weight: 50323 Da [This is the MW of the unprocessed precursor] CRC64: 1175DEA979244595 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLNLSRLSL LSSPRISIST HAPRKGYVCC SMKSYRLSEL SSSQVDSLKS RPRIDFSSIF 

        70         80         90        100        110        120 
ATVNPIIDAV RSNGDNAVKE YTERFDKVQL NKVVEDMSEL SVPELDSNVK EAFDVAYDNI 

       130        140        150        160        170        180 
YAFHLAQKST EKSVENMKGV RCKRVSRSIG SVGLYVPGGT AVLPSTALML AIPAQIAGCK 

       190        200        210        220        230        240 
TVVLATPPSK DGSICKEVLY CAKRAGVTHI LKAGGAQAIA AMAWGTDSCP KVEKIFGPGN 

       250        260        270        280        290        300 
QYVTAAKMIL QNSEAMVSID MPAGPSEVLV IADEHASPVY IAADLLSQAE HGPDSQVVLV 

       310        320        330        340        350        360 
VVGDSVDLNA IEEEIAKQCK SLPRGEFASK ALSHSFTVFA RDMIEAISFS NLYAPEHLII 

       370        380        390        400        410        420 
NVKDAEKWEG LIENAGSVFI GPWTPESVGD YASGTNHVLP TYGYARMYSG VSLDSFLKFM 

       430        440        450        460 
TVQSLTEEGL RNLGPYVATM AEIEGLDAHK RAVTLRLKDI EAKQLA 

Q9C5U8 in FASTA format

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