[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, AND ENZYME REGULATION.
TISSUE=Heart;
PubMed=10969042 [NCBI, ExPASy, EBI, Israel, Japan]
Donoghue M.,
Hsieh F.,
Baronas E.,
Godbout K.,
Gosselin M.,
Stagliano N.,
Donovan M.,
Woolf B.,
Robison K.,
Jeyaseelan R.,
Breitbart R.E.,
Acton S.;
"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.";
Circ. Res. 87:E1-E9(2000).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, GLYCOSYLATION, FUNCTION, AND ENZYME REGULATION.
TISSUE=Lymphoma;
DOI=10.1074/jbc.M002615200; PubMed=10924499 [NCBI, ExPASy, EBI, Israel, Japan]
Tipnis S.R.,
Hooper N.M.,
Hyde R.,
Karran E.,
Christie G.,
Turner A.J.;
"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.";
J. Biol. Chem. 275:33238-33243(2000).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND ENZYME REGULATION.
TISSUE=Testis;
DOI=10.1210/en.2004-0443; PubMed=15231706 [NCBI, ExPASy, EBI, Israel, Japan]
Douglas G.C.,
O'Bryan M.K.,
Hedger M.P.,
Lee D.K.L.,
Yarski M.A.,
Smith A.I.,
Lew R.A.;
"The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis.";
Endocrinology 145:4703-4711(2004).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT SER-638.
TISSUE=Lung, and Testis;
DOI=10.1002/ajmg.a.30779; PubMed=15937940 [NCBI, ExPASy, EBI, Israel, Japan]
Itoyama S.,
Keicho N.,
Hijikata M.,
Quy T.,
Phi N.C.,
Long H.T.,
Ha L.D.,
Ban V.V.,
Matsushita I.,
Yanai H.,
Kirikae F.,
Kirikae T.,
Kuratsuji T.,
Sasazuki T.;
"Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.";
Am. J. Med. Genet. A 136:52-57(2005).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Suzuki Y.,
Watanabe M.,
Sugano S.;
"Cloning, expression analysis and chromosomal localization of a novel ACE like enzyme.";
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F.,
Gurney A.L.,
Abaya E.,
Baker K.,
Baldwin D.T.,
Brush J.,
Chen J.,
Chow B.,
Chui C.,
Crowley C.,
Currell B.,
Deuel B.,
Dowd P.,
Eaton D.,
Foster J.S.,
Grimaldi C.,
Gu Q.,
Hass P.E.,
Heldens S., ![]()
Huang A.,
Kim H.S.,
Klimowski L.,
Jin Y.,
Johnson S.,
Lee J.,
Lewis L.,
Liao D.,
Mark M.R.,
Robbie E.,
Sanchez C.,
Schoenfeld J.,
Seshagiri S.,
Simmons L.,
Singh J.,
Smith V.,
Stinson J.,
Vagts A.,
Vandlen R.L.,
Watanabe C.,
Wieand D.,
Woods K.,
Xie M.-H.,
Yansura D.G.,
Yi S.,
Yu G.,
Yuan J.,
Zhang M.,
Zhang Z.,
Goddard A.D.,
Wood W.I.,
Godowski P.J.,
Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), AND VARIANT ARG-26.
SeattleSNPs program for genomic applications;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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[8]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[9]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-805 (ISOFORM 1).
TISSUE=Testis;
The German cDNA consortium;
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
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[10]
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PROTEIN SEQUENCE OF 679-689, IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH ITGB1.
DOI=10.1016/j.bbadis.2004.05.005; PubMed=15276642 [NCBI, ExPASy, EBI, Israel, Japan]
Lin Q.,
Keller R.S.,
Weaver B.,
Zisman L.S.;
"Interaction of ACE2 and integrin beta1 in failing human heart.";
Biochim. Biophys. Acta 1689:175-178(2004).
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[11]
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TISSUE SPECIFICITY.
DOI=10.1016/S0014-5793(02)03640-2; PubMed=12459472 [NCBI, ExPASy, EBI, Israel, Japan]
Harmer D.,
Gilbert M.,
Borman R.,
Clark K.L.;
"Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.";
FEBS Lett. 532:107-110(2002).
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[12]
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BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, AND COFACTOR.
DOI=10.1074/jbc.M200581200; PubMed=11815627 [NCBI, ExPASy, EBI, Israel, Japan]
Vickers C.,
Hales P.,
Kaushik V.,
Dick L.,
Gavin J.,
Tang J.,
Godbout K.,
Parsons T.,
Baronas E.,
Hsieh F.,
Acton S.,
Patane M.A.,
Nichols A.,
Tummino P.;
"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.";
J. Biol. Chem. 277:14838-14843(2002).
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[13]
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FUNCTION, INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN, GLYCOSYLATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
DOI=10.1038/nature02145; PubMed=14647384 [NCBI, ExPASy, EBI, Israel, Japan]
Li W.,
Moore M.J.,
Vasilieva N.,
Sui J.,
Wong S.-K.,
Berne M.A.,
Somasundaran M.,
Sullivan J.L.,
Luzuriaga K.,
Greenough T.C.,
Choe H.,
Farzan M.;
"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.";
Nature 426:450-454(2003).
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[14]
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INDUCTION.
DOI=10.1186/1741-7015-2-19; PubMed=15151696 [NCBI, ExPASy, EBI, Israel, Japan]
Goulter A.B.,
Goddard M.J.,
Allen J.C.,
Clark K.L.;
"ACE2 gene expression is up-regulated in the human failing heart.";
BMC Med. 2:19-19(2004).
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[15]
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TISSUE SPECIFICITY.
DOI=10.1002/path.1570; PubMed=15141377 [NCBI, ExPASy, EBI, Israel, Japan]
Hamming I.,
Timens W.,
Bulthuis M.L.C.,
Lely A.T.,
Navis G.J.,
van Goor H.;
"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.";
J. Pathol. 203:631-637(2004).
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[16]
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INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN.
DOI=10.1128/JVI.78.20.11429-11433.2004; PubMed=15452268 [NCBI, ExPASy, EBI, Israel, Japan]
Li W.,
Greenough T.C.,
Moore M.J.,
Vasilieva N.,
Somasundaran M.,
Sullivan J.L.,
Farzan M.,
Choe H.;
"Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2.";
J. Virol. 78:11429-11433(2004).
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[17]
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GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-90, AND MASS SPECTROMETRY.
TISSUE=Bile;
DOI=10.1074/mcp.M400015-MCP200; PubMed=15084671 [NCBI, ExPASy, EBI, Israel, Japan]
Kristiansen T.Z.,
Bunkenborg J.,
Gronborg M.,
Molina H.,
Thuluvath P.J.,
Argani P.,
Goggins M.G.,
Maitra A.,
Pandey A.;
"A proteomic analysis of human bile.";
Mol. Cell. Proteomics 3:715-728(2004).
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[18]
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TISSUE SPECIFICITY, AND INDUCTION.
DOI=10.1093/eurheartj/ehi114; PubMed=15671045 [NCBI, ExPASy, EBI, Israel, Japan]
Burrell L.M.,
Risvanis J.,
Kubota E.,
Dean R.G.,
MacDonald P.S.,
Lu S.,
Tikellis C.,
Grant S.L.,
Lew R.A.,
Smith A.I.,
Cooper M.E.,
Johnston C.I.;
"Myocardial infarction increases ACE2 expression in rat and humans.";
Eur. Heart J. 26:369-375(2005).
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[19]
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INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN, AND MUTAGENESIS.
DOI=10.1038/sj.emboj.7600640; PubMed=15791205 [NCBI, ExPASy, EBI, Israel, Japan]
Li W.,
Zhang C.,
Sui J.,
Kuhn J.H.,
Moore M.J.,
Luo S.,
Wong S.-K.,
Huang I.-C.,
Xu K.,
Vasilieva N.,
Murakami A.,
He Y.,
Marasco W.A.,
Guan Y.,
Choe H.,
Farzan M.;
"Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2.";
EMBO J. 24:1634-1643(2005).
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[20]
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PROTEOLYTIC CLEAVAGE.
DOI=10.1074/jbc.M505111200; PubMed=15983030 [NCBI, ExPASy, EBI, Israel, Japan]
Lambert D.W.,
Yarski M.,
Warner F.J.,
Thornhill P.,
Parkin E.T.,
Smith A.I.,
Hooper N.M.,
Turner A.J.;
"Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).";
J. Biol. Chem. 280:30113-30119(2005).
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[21]
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INTERACTION WITH HCOV-NL63 SPIKE GLYCOPROTEIN.
DOI=10.1073/pnas.0409465102; PubMed=15897467 [NCBI, ExPASy, EBI, Israel, Japan]
Hofmann H.,
Pyrc K.,
van der Hoek L.,
Geier M.,
Berkhout B.,
Poehlmann S.;
"Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry.";
Proc. Natl. Acad. Sci. U.S.A. 102:7988-7993(2005).
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[22]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 19-615, X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 19-615 IN COMPLEX WITH MLN-4760, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-53; ASN-90; ASN-103; ASN-322; ASN-432 AND ASN-546.
DOI=10.1074/jbc.M311191200; PubMed=14754895 [NCBI, ExPASy, EBI, Israel, Japan]
Towler P.,
Staker B.,
Prasad S.G.,
Menon S.,
Tang J.,
Parsons T.,
Ryan D.,
Fisher M.,
Williams D.,
Dales N.A.,
Patane M.A.,
Pantoliano M.W.;
"ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.";
J. Biol. Chem. 279:17996-18007(2004).
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