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UniProtKB/Swiss-Prot entry Q9BXW4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MLP3C_HUMAN
Primary accession number Q9BXW4
Secondary accession numbers A0PJY8 A2RUP0
Integrated into Swiss-Prot on May 10, 2005
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 47)
Name and origin of the protein
Protein name Microtubule-associated proteins 1A/1B light chain 3C [Precursor]
Synonyms Microtubule-associated protein 1 light chain 3 gamma
MAP1A/1B light chain 3 C
MAP1A/MAP1B LC3 C
MAP1 light chain 3-like protein 3
Autophagy-related protein LC3 C
Autophagy-related ubiquitin-like modifier LC3 C
Gene name
Name: MAP1LC3C
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MUTAGENESIS OF GLY-126.
DOI=10.1074/jbc.M303800200; PubMed=12740394 [NCBI, ExPASy, EBI, Israel, Japan]
He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y., Ling W., Wu C., Zhao S., Liu J.O., Yu L.;
"Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.";
J. Biol. Chem. 278:29278-29287(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
LIPIDATION, AND CLEAVAGE BY APG4B.
DOI=10.1074/jbc.M401461200; PubMed=15187094 [NCBI, ExPASy, EBI, Israel, Japan]
Tanida I., Sou Y.-S., Ezaki J., Minematsu-Ikeguchi N., Ueno T., Kominami E.;
"HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.";
J. Biol. Chem. 279:36268-36276(2004).
Comments
  • FUNCTION: Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity).
  • SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity).
  • SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes.
  • TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary.
  • PTM: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
  • SIMILARITY: Belongs to the MAP1 LC3 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF276659; AAK35152.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX571673; CAH72477.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC127722; AAI27723.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC132986; AAI32987.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC132988; AAI32989.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00387017; -.
RefSeq NP_001004343.1; -.
UniGene Hs.534971
3D structure databases
HSSP P60519; 1EO6. [HSSP ENTRY / PDB]
ModBase Q9BXW4.
Organism-specific databases
GeneCards GC01M240225; -.
H-InvDB HIX0028588; -.
HGNC HGNC:13353; MAP1LC3C.
GenAtlas MAP1LC3C.
MIM 609605; gene. [NCBI / EBI]
PharmGKB PA142671482; -.
Gene expression databases
Bgee Q9BXW4; -.
CleanEx HS_MAP1LC3C; -.
GermOnline ENSG00000197769; Homo sapiens.
Ontologies
GO
GO:0000421; Cellular component: autophagic vacuole membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0031410; Cellular component: cytoplasmic vesicle (inferred from electronic annotation from UniProtKB-SubCell).
GO:0012505; Cellular component: endomembrane system (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005874; Cellular component: microtubule (inferred from electronic annotation from UniProtKB-KW).
GO:0006914; Biological process: autophagy (inferred from electronic annotation from UniProtKB-KW).
GO:0019941; Biological process: modification-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR004241; MAP1_LC3.
Graphical view of domain structure.
PANTHER PTHR10969; MAP1_LC3; 1.
Pfam PF02991; MAP1_LC3; 1.
Pfam graphical view of domain structure.
Proteomic databases
PRIDE Q9BXW4; -.
Genome annotation databases
Ensembl ENSG00000197769; Homo sapiens. [Contig view]
GeneID 440738; -.
KEGG hsa:440738; -.
Phylogenomic databases
HOGENOM Q9BXW4; -.
HOVERGEN Q9BXW4; -.
OMA Q9BXW4; IRSRMVL.
Other
NextBio 109492; -.
SOURCE MAP1LC3C; Homo sapiens.
ProtoNet Q9BXW4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Autophagy; Cytoplasm; Cytoplasmic vesicle; Lipoprotein; Membrane; Microtubule; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   126  126     Microtubule-associated proteins 1A/1B light chain 3C. PRO_0000017204
PROPEP   127   147  21     Removed in mature form. PRO_0000017205
LIPID   126   126        Phosphatidylethanolamine amidated glycine (Probable). 
MUTAGEN   126   126        G->A: No processing of precursor. 
Sequence information
Length: 147 AA [This is the length of the unprocessed precursor] Molecular weight: 16852 Da [This is the MW of the unprocessed precursor] CRC64: D3DFA8EE5985C3AA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPPPQKIPSV RPFKQRKSLA IRQEEVAGIR AKFPNKIPVV VERYPRETFL PPLDKTKFLV 

        70         80         90        100        110        120 
PQELTMTQFL SIIRSRMVLR ATEAFYLLVN NKSLVSMSAT MAEIYRDYKD EDGFVYMTYA 

       130        140 
SQETFGCLES AAPRDGSSLE DRPCNPL 

Q9BXW4 in FASTA format

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