ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q96F86


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name EDC3_HUMAN
Primary accession number Q96F86
Secondary accession number Q9H797
Integrated into Swiss-Prot on November 22, 2005
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 51)
Name and origin of the protein
Protein name Enhancer of mRNA-decapping protein 3
Synonyms YjeF domain-containing protein 1
LSM16 homolog
Gene name
Name: EDC3
Synonyms: LSM16, YJDC
ORFNames: PP844
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1073/pnas.0404089101; PubMed=15498874 [NCBI, ExPASy, EBI, Israel, Japan]
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X., Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
"Large-scale cDNA transfection screening for genes related to cancer development and progression.";
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH DCP1A; DCP2; DDX6; EDC4 AND ZFP36, SUBCELLULAR LOCATION, AND FUNCTION.
DOI=10.1016/j.molcel.2005.10.031; PubMed=16364915 [NCBI, ExPASy, EBI, Israel, Japan]
Fenger-Groen M., Fillman C., Norrild B., Lykke-Andersen J.;
"Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.";
Mol. Cell 20:905-915(2005).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[8]
X-RAY CRYSTALLOGRAPHY (1.31 ANGSTROMS) OF 1-82.
DOI=10.1128/MCB.01506-07; PubMed=17923697 [NCBI, ExPASy, EBI, Israel, Japan]
Tritschler F., Eulalio A., Truffault V., Hartmann M.D., Helms S., Schmidt S., Coles M., Izaurralde E., Weichenrieder O.;
"A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.";
Mol. Cell. Biol. 27:8600-8611(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF193058; AAG22486.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK024781; BAB15001.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011534; AAH11534.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC021271; AAH21271.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_079359.2; -.
UniGene Hs.96852
3D structure databases
PDB
2VC8; X-ray; 1.31 A; A=1-82.[ExPASy / RCSB / EBI]
PDBsum 2VC8; -.
ModBase Q96F86.
Protein-protein interaction databases
IntAct Q96F86; -.
PTM databases
PhosphoSite Q96F86; -.
Organism-specific databases
H-InvDB HIX0020864; -.
HGNC HGNC:26114; EDC3.
GenAtlas EDC3.
MIM 609842; gene. [NCBI / EBI]
GeneCards Q96F86.
Gene expression databases
ArrayExpress Q96F86; -.
CleanEx HS_EDC3; -.
GermOnline ENSG00000179151; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR004443; YjeF_N.
Graphical view of domain structure.
Pfam PF03853; YjeF_N; 1.
Pfam graphical view of domain structure.
PROSITE PS51385; YJEF_N; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q96F86.
Proteomic databases
PeptideAtlas Q96F86; -.
Genome annotation databases
Ensembl ENSG00000179151; Homo sapiens. [Contig view]
GeneID 80153; -.
KEGG hsa:80153; -.
Phylogenomic databases
HOGENOM Q96F86; -.
HOVERGEN Q96F86; -.
Other
SOURCE EDC3; Homo sapiens.
ProtoNet Q96F86.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   508  508     Enhancer of mRNA-decapping protein 3. PRO_0000119054
DOMAIN   283   487  205     YjeF N-terminal. 
REGION   1    79  79     Required for P-body targeting and interaction with DCP1A (By similarity). 
REGION   191   296  106     Required for interaction with DDX6 (By similarity). 
MOD_RES   131   131        Phosphoserine. 
MOD_RES   161   161        Phosphoserine. 
CONFLICT   74    74        Q -> R (in Ref. 2; BAB15001). 
Sequence information
Length: 508 AA [This is the length of the unprocessed precursor] Molecular weight: 56078 Da [This is the MW of the unprocessed precursor] CRC64: 95346F484FCFC3EA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATDWLGSIV SINCGDSLGV YQGRVSAVDQ VSQTISLTRP FHNGVKCLVP EVTFRAGDIT 

        70         80         90        100        110        120 
ELKILEIPGP GDNQHFGDLH QTELGPSGAG CQVGINQNGT GKFVKKPASS SSAPQNIPKR 

       130        140        150        160        170        180 
TDVKSQDVAV SPQQQQCSKS YVDRHMESLS QSKSFRRRHN SWSSSSRHPN QATPKKSGLK 

       190        200        210        220        230        240 
NGQMKNKDDE CFGDDIEEIP DTDFDFEGNL ALFDKAAVFE EIDTYERRSG TRSRGIPNER 

       250        260        270        280        290        300 
PTRYRHDENI LESEPIVYRR IIVPHNVSKE FCTDSGLVVP SISYELHKKL LSVAEKHGLT 

       310        320        330        340        350        360 
LERRLEMTGV CASQMALTLL GGPNRLNPKN VHQRPTVALL CGPHVKGAQG ISCGRHLANH 

       370        380        390        400        410        420 
DVQVILFLPN FVKMLESITN ELSLFSKTQG QQVSSLKDLP TSPVDLVINC LDCPENVFLR 

       430        440        450        460        470        480 
DQPWYKAAVA WANQNRAPVL SIDPPVHEVE QGIDAKWSLA LGLPLPLGEH AGRIYLCDIG 

       490        500 
IPQQVFQEVG INYHSPFGCK FVIPLHSA 

Q96F86 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!