[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Placenta; Ota T., Nishikawa T., Suzuki Y., Kawai-Hio Y., Hayashi K., Ishii S., Saito K., Yamamoto J., Wakamatsu A., Nagai T., Nakamura Y., Nagahari K., Sugano S., Isogai T.; "HRI human cDNA sequencing project."; Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas subfamily [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AK075450; BAC11628.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC016964; AAH16964.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00059513; -.

RefSeq

NP_001091985.1; -.
NP_659452.3; -.

UniGene

Hs.118513

3D structure databases

ModBase

Q96AM1.

Protein family/group databases

GPCRDB

Q96AM1; MRGRF_HUMAN.

Organism-specific databases

GC11M068528; -.

HGNC:24828; MRGPRF.

607233; gene. [NCBI / EBI]

PharmGKB

PA134896544; -.

Gene expression databases

Q96AM1; -.

Q96AM1; -.

HS_MRGPRF; -.

ENSG00000172935; Homo sapiens.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004930;	Molecular function: G-protein coupled receptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00237; GPCRRHODOPSN.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q96AM1; -.

Genome annotation databases

Ensembl

ENSG00000172935; Homo sapiens. [Contig view]

GeneID

116535; -.

KEGG

hsa:219928; -.

Phylogenomic databases

HOGENOM

Q96AM1; -.

HOVERGEN

Q96AM1; -.

OMA

Q96AM1; CPLMVLP.

Other

NextBio

90852; -.

SOURCE

MRGPRF; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 343`	`343`	`Mas-related G-protein coupled receptor member F.`	`PRO_0000069764`
`TOPO_DOM`	`1 44`	`44`	`Extracellular (Potential).`
`TRANSMEM`	`45 66`	`22`	`1 (Potential).`
`TOPO_DOM`	`67 82`	`16`	`Cytoplasmic (Potential).`
`TRANSMEM`	`83 104`	`22`	`2 (Potential).`
`TOPO_DOM`	`105 123`	`19`	`Extracellular (Potential).`
`TRANSMEM`	`124 144`	`21`	`3 (Potential).`
`TOPO_DOM`	`145 160`	`16`	`Cytoplasmic (Potential).`
`TRANSMEM`	`161 181`	`21`	`4 (Potential).`
`TOPO_DOM`	`182 198`	`17`	`Extracellular (Potential).`
`TRANSMEM`	`199 220`	`22`	`5 (Potential).`
`TOPO_DOM`	`221 241`	`21`	`Cytoplasmic (Potential).`
`TRANSMEM`	`242 263`	`22`	`6 (Potential).`
`TOPO_DOM`	`264 273`	`10`	`Extracellular (Potential).`
`TRANSMEM`	`274 294`	`21`	`7 (Potential).`
`TOPO_DOM`	`295 343`	`49`	`Cytoplasmic (Potential).`
`CARBOHYD`	`4 4`		`N-linked (GlcNAc...) (Potential).`
`CONFLICT`	`16 16`		`K -> R (in Ref. 1; BAC11628).`

Sequence information

Length: 343 AA [This is the length of the unprocessed precursor]

Molecular weight: 38171 Da [This is the MW of the unprocessed precursor]

CRC64: 168A649F5B38F154 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAGNCSWEAH PGNRNKMCPG LSEAPELYSR GFLTIEQIAM LPPPAVMNYI FLLLCLCGLV 

        70         80         90        100        110        120 
GNGLVLWFFG FSIKRNPFSI YFLHLASADV GYLFSKAVFS ILNTGGFLGT FADYIRSVCR 

       130        140        150        160        170        180 
VLGLCMFLTG VSLLPAVSAE RCASVIFPAW YWRRRPKRLS AVVCALLWVL SLLVTCLHNY 

       190        200        210        220        230        240 
FCVFLGRGAP GAACRHMDIF LGILLFLLCC PLMVLPCLAL ILHVECRARR RQRSAKLNHV 

       250        260        270        280        290        300 
ILAMVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ 

       310        320        330        340 
RLWEPLRVVF QRALRDGAEL GEAGGSTPNT VTMEMQCPPG NAS

Q96AM1 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools