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UniProtKB/Swiss-Prot entry Q95126

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AVR2B_BOVIN
Primary accession number Q95126
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 68)
Name and origin of the protein
Protein name Activin receptor type-2B [Precursor]
Synonyms EC 2.7.11.30
Activin receptor type IIB
ACTR-IIB
Gene name
Name: ACVR2B
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Corpus luteum, and Pituitary;
DOI=10.1210/en.138.6.2425; PubMed=9165032 [NCBI, ExPASy, EBI, Israel, Japan]
Ethier J.-F., Lussier J.G., Silversides D.W.;
"Bovine activin receptor type IIB messenger ribonucleic acid displays alternative splicing involving a sequence homologous to Src-homology 3 domain binding sites.";
Endocrinology 138:2425-2434(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U57707; AAC02647.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_776920.1; -.
UniGene Bt.4990
3D structure databases
HSSP P27038; 1BTE. [HSSP ENTRY / PDB]
SMR Q95126; 24-117.
ModBase Q95126.
Family and domain databases
InterPro IPR000333; Activin_II_recpt.
IPR015768; Activin_II_recpt_C.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
PANTHER PTHR23255:SF10; Activin_II_recpt_C; 1.
Pfam PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
PRINTS PR00653; ACTIVIN2R.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q95126.
Genome annotation databases
Ensembl ENSBTAG00000018105; Bos taurus. [Contig view]
GeneID 282131; -.
KEGG bta:282131; -.
Phylogenomic databases
HOVERGEN Q95126; -.
Other
ProtoNet Q95126.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Potential. 
CHAIN   19   512  494     Activin receptor type-2B. PRO_0000024403
TOPO_DOM   19   137  119     Extracellular (Potential). 
TRANSMEM   138   158  21     Potential. 
TOPO_DOM   159   512  354     Cytoplasmic (Potential). 
DOMAIN   190   480  291     Protein kinase. 
NP_BIND   196   204  9     ATP (By similarity). 
ACT_SITE   321   321        Proton acceptor (By similarity). 
BINDING   217   217        ATP (By similarity). 
CARBOHYD   42    42        N-linked (GlcNAc...) (Potential). 
CARBOHYD   65    65        N-linked (GlcNAc...) (Potential). 
DISULFID   29    59        By similarity. 
DISULFID   49    77        By similarity. 
DISULFID   84   103        By similarity. 
DISULFID   90   102        By similarity. 
DISULFID   104   109        By similarity. 
Sequence information
Length: 512 AA [This is the length of the unprocessed precursor] Molecular weight: 57569 Da [This is the MW of the unprocessed precursor] CRC64: D8E14D465B3EEF04 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GERDKRLHCY 

        70         80         90        100        110        120 
ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 

       130        140        150        160        170        180 
GPEVTYEPPP TAPTLLTVLA YSLLPVGGLS LIALLAFWMY RHRKPPYGHA DIHEDPGPPP 

       190        200        210        220        230        240 
PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 

       250        260        270        280        290        300 
HENLLQFIAA EKRGSSLEAE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 

       310        320        330        340        350        360 
LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 

       370        380        390        400        410        420 
TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 

       430        440        450        460        470        480 
HPSLEELQEV VVHKKMRPAI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 

       490        500        510 
IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI
Q95126 in FASTA format

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