ID   FGF13_HUMAN             Reviewed;         245 AA.
AC   Q92913; O95830;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   02-SEP-2008, entry version 73.
DE   RecName: Full=Fibroblast growth factor 13;
DE            Short=FGF-13;
DE   AltName: Full=Fibroblast growth factor homologous factor 2;
DE            Short=FHF-2;
GN   Name=FGF13; Synonyms=FHF2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
RC   TISSUE=Retina;
RX   MEDLINE=96382556; PubMed=8790420; DOI=10.1073/pnas.93.18.9850;
RA   Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H.,
RA   Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.;
RT   "Fibroblast growth factor (FGF) homologous factors: new members of the
RT   FGF family implicated in nervous system development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B).
RC   TISSUE=Brain;
RX   MEDLINE=99168751; PubMed=10071193; DOI=10.1007/s004390050910;
RA   Gecz J., Baker E., Donnelly A., Ming J.E., McDonnald-McGinn D.M.,
RA   Spinner N.B., Zackai E.H., Sutherland G.R., Mulley J.C.;
RT   "Fibroblast growth factor homologous factor 2 (FHF2): gene structure,
RT   expression and mapping to the Borjeson-Forssman-Lehmann syndrome
RT   region in Xq26 delineated by a duplication breakpoint in a BFLS-like
RT   patient.";
RL   Hum. Genet. 104:56-63(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-197.
RA   Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,
RA   Nguyen C.P., Nguyen D.A., Poel C.L., Chambers S.W., Schackwitz W.S.,
RA   Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.;
RT   "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department
RT   of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
RC   TISSUE=Lung, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably involved in nervous system development and
CC       function.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1A;
CC         IsoId=Q92913-1; Sequence=Displayed;
CC       Name=1B;
CC         IsoId=Q92913-2; Sequence=VSP_001529;
CC   -!- TISSUE SPECIFICITY: Nervous system.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; U66198; AAB18914.1; -; mRNA.
DR   EMBL; AF100143; AAD16400.1; -; mRNA.
DR   EMBL; AF100144; AAD16401.1; -; mRNA.
DR   EMBL; AY672645; AAT70720.1; -; Genomic_DNA.
DR   EMBL; BC012347; AAH12347.1; -; mRNA.
DR   EMBL; BC034340; AAH34340.1; -; mRNA.
DR   RefSeq; NP_004105.1; -.
DR   RefSeq; NP_378668.1; -.
DR   UniGene; Hs.6540; -.
DR   HSSP; P31371; 1G82.
DR   SMR; Q92913; 64-201.
DR   Ensembl; ENSG00000129682; Homo sapiens.
DR   GeneID; 2258; -.
DR   KEGG; hsa:2258; -.
DR   H-InvDB; HIX0017088; -.
DR   HGNC; HGNC:3670; FGF13.
DR   HPA; HPA002809; -.
DR   MIM; 300070; gene.
DR   PharmGKB; PA28109; -.
DR   HOVERGEN; Q92913; -.
DR   ArrayExpress; Q92913; -.
DR   CleanEx; HS_FGF13; -.
DR   GermOnline; ENSG00000129682; Homo sapiens.
DR   GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   InterPro; IPR002209; GF_heparin_bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   ProDom; PD000831; IL1_HBGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Growth factor; Polymorphism.
FT   CHAIN         1    245       Fibroblast growth factor 13.
FT                                /FTId=PRO_0000147607.
FT   VAR_SEQ       1     62       MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKN
FT                                KLNVFSRVKLFGSKKRRRRRP -> MALLRKSYS (in
FT                                isoform 1B).
FT                                /FTId=VSP_001529.
FT   VARIANT     197    197       K -> Q.
FT                                /FTId=VAR_020945.
SQ   SEQUENCE   245 AA;  27564 MW;  30FB62C6B2669F29 CRC64;
     MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR
     RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK
     LYLAMNSEGY LYTSELFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM
     KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS
     HNEST
//