ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q91845

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name EPA4A_XENLA
Primary accession number Q91845
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 78)
Name and origin of the protein
Protein name Ephrin type-A receptor 4-A [Precursor]
Synonyms EC 2.7.10.1
Tyrosine-protein kinase receptor SEK-1
xSEK-1
Gene name
Name: epha4-A
Synonyms: sek1
From
Xenopus laevis (African clawed frog) [TaxID: 8355] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8575301 [NCBI, ExPASy, EBI, Israel, Japan]
Xu Q., Alldus G., Holder N., Wilkinson D.G.;
"Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain.";
Development 121:4005-4016(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X91191; CAA62601.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001090183.1; -.
UniGene Xl.57159
3D structure databases
HSSP P54763; 1JPA. [HSSP ENTRY / PDB]
SMR Q91845; 612-887, 910-981.
ModBase Q91845.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0005003; Molecular function: ephrin receptor activity (inferred from electronic annotation from InterPro).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
GO:0007169; Biological process: transmembrane receptor protein tyrosine kinase signaling pathway (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013032; EGF_like_reg_CS.
IPR001090; Eph_rcpt_lig_bd.
IPR008957; Fibronectin_typ-III-like_fold.
IPR003961; FN_III.
IPR003962; FnIII_subd.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR001660; SAM.
IPR011510; SAM_2.
IPR013761; SAM_type.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
IPR016257; TyrPK_ephrin_receptor.
IPR001426; YKase_receptorV_CS.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 2.
G3DSA:1.10.150.50; SAM_type; 1.
Pfam PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000666; TyrPK_ephrin_receptor; 1.
PRINTS PR00014; FNTYPEIII.
PR00109; TYRKINASE.
ProDom PD001495; Ephrin_receptor; 1.
PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS01186; EGF_2; UNKNOWN_1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q91845.
Genome annotation databases
GeneID 779062; -.
KEGG xla:779062; -.
Phylogenomic databases
HOVERGEN Q91845; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
CHAIN   21   986  966     Ephrin type-A receptor 4-A. PRO_0000016810
TOPO_DOM   21   547  527     Extracellular (Potential). 
TRANSMEM   548   569  22     Potential. 
TOPO_DOM   570   986  417     Cytoplasmic (Potential). 
DOMAIN   328   430  103     Fibronectin type-III 1. 
DOMAIN   440   533  94     Fibronectin type-III 2. 
DOMAIN   620   881  262     Protein kinase. 
DOMAIN   911   975  65     SAM. 
NP_BIND   626   634  9     ATP (By similarity). 
MOTIF   984   986  3     PDZ-binding (Potential). 
COMPBIAS   191   325  135     Cys-rich. 
ACT_SITE   745   745        Proton acceptor (By similarity). 
BINDING   652   652        ATP (By similarity). 
MOD_RES   595   595        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   601   601        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   778   778        Phosphotyrosine; by autocatalysis (Potential). 
MOD_RES   928   928        Phosphotyrosine; by autocatalysis (Potential). 
CARBOHYD   340   340        N-linked (GlcNAc...) (Potential). 
CARBOHYD   407   407        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 986 AA [This is the length of the unprocessed precursor] Molecular weight: 109841 Da [This is the MW of the unprocessed precursor] CRC64: C34F4078DB3F025F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGIVHGILF CGLFGLCWAV TGSRIYPASE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 

        70         80         90        100        110        120 
DEKNTPIRTY QVCNVMESSQ NNWLRTDWIP RSGAQRVYVE IKFTLRDCNS LPGVMGTCKE 

       130        140        150        160        170        180 
TFNLYYYESN NDKERFIRET QYVKIDTIAA DESFTQVDIG DRIMKLNTEV RDVGPLSKKG 

       190        200        210        220        230        240 
FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG SDTSSLVEVR GSCVDNSEEK 

       250        260        270        280        290        300 
DVPKMYCGAD GEWLVPIGNC LCNAGFEEHN GGCQACKVGY YKALSTDAAC SKCPPHSYAL 

       310        320        330        340        350        360 
REGSTSCTCD RGYFRADTDP ASMPCTRPPS APQNLISNVN ETSVNLEWSP PQNSGGRPDV 

       370        380        390        400        410        420 
SYNLVCKRCG SDLTRCRPCG SGVHYSPQQN GLKTTKVSIT DLQAHTNYTF EVWSINGVSK 

       430        440        450        460        470        480 
QNPGQDQAVS VTVTTNQAAP STVTQIQPKD ITRHSVSLTW PEPERPNGVI LEYEVKYYEK 

       490        500        510        520        530        540 
DQNERTYRIV KTTSRSADIK GLNPLTAYVF HVRARTAAGY GEFSGPFEFT TNTVPSPMIG 

       550        560        570        580        590        600 
EGASPTVLLV SVAGSIVLVV ILIAAFVISR RRSKYSKAKQ EADEEKHLNQ GVKTYVDPFT 

       610        620        630        640        650        660 
YEDPNQAVRE FAKEIDASCI KIEKVIGVGE FGEVCSGRLK VPGKREIYVA IKTLKAGYTD 

       670        680        690        700        710        720 
KQRRDFLSEA SIMGQFDHPN IIHLEGVVTK CKPVMIITEY MENGSLDAFL RKNDGRFTVI 

       730        740        750        760        770        780 
QLVGILRGIG SGMKYLSDMS YVHRDLAARN ILVNSNLVCK VSDFGMSRVL EDDPEAAYTT 

       790        800        810        820        830        840 
RGGKIPIRWT APEAIAYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMSNQ DVIKAIEEGY 

       850        860        870        880        890        900 
RLPPPMDCPI ALHQLMLDCW QKERSDRPKF GQIVSMLDKL IRNPNSLKRT GLDNSSRTNT 

       910        920        930        940        950        960 
TLLDPSSPEW SQVASVLDWL QAIKMERYKD NFTAAGYTSL EAVVHVNQDD LTRIGISSPS 

       970        980 
HQNKILSSVQ GMRTQMQQIQ GRMVPV
Q91845 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!