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UniProtKB/Swiss-Prot entry Q91735

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name EPHB3_XENLA
Primary accession number Q91735
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 81)
Name and origin of the protein
Protein name Ephrin type-B receptor 3 [Precursor]
Synonyms EC 2.7.10.1
Tyrosine-protein kinase receptor TCK
Gene name
Name: ephb3
Synonyms: tck
From
Xenopus laevis (African clawed frog) [TaxID: 8355] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7478602 [NCBI, ExPASy, EBI, Israel, Japan]
Scales J.B., Winning R.S., Renaud C.S., Shea L.J., Sargent T.D.;
"Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development.";
Oncogene 11:1745-1752(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L43620; AAA93526.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001081434.1; -.
UniGene Xl.1027
3D structure databases
HSSP P54763; 1JPA. [HSSP ENTRY / PDB]
SMR Q91735; 582-879, 898-968.
ModBase Q91735.
Family and domain databases
InterPro IPR001090; Eph_rcpt_lig_bd.
IPR008957; Fibronectin_typ-III-like_fold.
IPR003961; FN_III.
IPR003962; FnIII_subd.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR001660; SAM.
IPR011510; SAM_2.
IPR013761; SAM_type.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
IPR016257; TyrPK_ephrin_receptor.
IPR001426; YKase_receptorV_CS.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 1.
G3DSA:1.10.150.50; SAM_type; 1.
Pfam PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000666; TyrPK_ephrin_receptor; 1.
PRINTS PR00014; FNTYPEIII.
PR00109; TYRKINASE.
ProDom PD001495; Ephrin_receptor; 1.
PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q91735.
ProtoNet Q91735.
Genome annotation databases
GeneID 397834; -.
KEGG xla:397834; -.
Phylogenomic databases
HOVERGEN Q91735; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    16  16     Potential. 
CHAIN   17   974  958     Ephrin type-B receptor 3. PRO_0000016833
TOPO_DOM   17   534  518     Extracellular (Potential). 
TRANSMEM   535   555  21     Potential. 
TOPO_DOM   556   974  419     Cytoplasmic (Potential). 
DOMAIN   319   418  100     Fibronectin type-III 1. 
DOMAIN   424   518  95     Fibronectin type-III 2. 
DOMAIN   609   872  264     Protein kinase. 
DOMAIN   901   965  65     SAM. 
NP_BIND   615   623  9     ATP (By similarity). 
MOTIF   972   974  3     PDZ-binding (Potential). 
COMPBIAS   178   315  138     Cys-rich. 
ACT_SITE   734   734        Proton acceptor (By similarity). 
BINDING   641   641        ATP (By similarity). 
MOD_RES   584   584        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   590   590        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   768   768        Phosphotyrosine; by autocatalysis (Potential). 
MOD_RES   918   918        Phosphotyrosine; by autocatalysis (By similarity). 
CARBOHYD   330   330        N-linked (GlcNAc...) (Potential). 
CARBOHYD   420   420        N-linked (GlcNAc...) (Potential). 
DISULFID   60    95        By similarity. 
Sequence information
Length: 974 AA [This is the length of the unprocessed precursor] Molecular weight: 108264 Da [This is the MW of the unprocessed precursor] CRC64: F881412E86628533 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLPAVFVILA LSAVQGLEET LMDTKWTTSE LAWVAYPDSG WEEVSGYDEA SNPIRTYQVC 

        70         80         90        100        110        120 
NVRDSNQNNW LRTQFIPRQD VQRVYVELKF TVRDCNSLPN LRGSCKETFN FFYYESDSDS 

       130        140        150        160        170        180 
ASADSPFWME NPYIKVDTIA PDESFSRRDS GRVNTKIRSF GPISRAGFYL AFQDLGACVS 

       190        200        210        220        230        240 
LISVRVFFKK CPRTTAGFAS FPETITGAEP TSLVIAPGTC VPNALEVSVP LKLYCNGDGD 

       250        260        270        280        290        300 
WMVPVGACTC AAGFEPAGKD TQCQACKRGT YKSKQGEGSC MPCPANSRAI SSAATICSCQ 

       310        320        330        340        350        360 
NGYYRADGES AETACTSVPS APRQVISNVN ETSVVLEWAE PGHLGGRDDV LYNVICKKCL 

       370        380        390        400        410        420 
ERLCSRCDDN VQFWPRQLGV TQRLVSVSHL QAHTKYSFEI QAVNGVSGKS PHIPNYFTVN 

       430        440        450        460        470        480 
ITTNQAAPSS VPMVQSHGSL ANSLTLSWAP PESPNGIILD YEIKYYAKGH IGAGNTVTSQ 

       490        500        510        520        530        540 
RTTVRMEGMT PDTVYVVQVR ARTVAGYGAY SEPREFQTIA EDGDRSSLQE QVPMVVGSVT 

       550        560        570        580        590        600 
AGLIFIIAVV IIVIVCFSRK QRNDSESEYT EKLQQYMVPG MKLYIDPFTY EDPNEAVRDF 

       610        620        630        640        650        660 
AKEIDISCVK IEEVIGAGEF GEVCRGKLKQ AGRREQFVAI KTLKAGYTEQ QRRDFLGEAS 

       670        680        690        700        710        720 
IMGQFDHPNI IRLEGVVTRS RPVMILTEFM ENGALDSFLR MNDGQFTVIQ LVGILRGIAS 

       730        740        750        760        770        780 
GMKYLSEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRFLE NSRSDPTYTS ALGGKIPIRW 

       790        800        810        820        830        840 
TAPEAISYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVINAIEQD YRLPPPMDCP 

       850        860        870        880        890        900 
SALHQLMLDC WLRDRNLRPK FSQIVSSLDK LIRNAASLKV TSPGQAGVSQ QLLDRTVPDY 

       910        920        930        940        950        960 
TTFPTVSDWL EAIKMGQYQE NFLSAGFTSF HLVAQMTAED LLRIGVTLAG HQKKLLNSVQ 

       970 
DMRLQMSQTL PVQV
Q91735 in FASTA format

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