[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=7700636 [NCBI, ExPASy, EBI, Israel, Japan] Jones T.L., Karavanova I., Maeno M., Ong R.C., Kung H.-F., Daar I.O.; "Expression of an amphibian homolog of the Eph family of receptor tyrosine kinases is developmentally regulated."; Oncogene 10:1111-1117(1995).

Comments

FUNCTION: Receptor for members of the ephrin-B family. May play a role in the development or function of the central nervous system.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DEVELOPMENTAL STAGE: Maternally expressed, it decreases at mid blastula transition and reappears at late neurulation. Expressed at higher levels in the anterior and dorsal regions of embryonic stages 16, 24 and 37. In adult it appears to be ubiquitously expressed with higher expression in brain and ovary. Expression in the brain, brachial arches, trigeminal facial ganglion, and the retina of swimming tadpole stage of development.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
SIMILARITY: Contains 2 fibronectin type-III domains.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 SAM (sterile alpha motif) domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U14164; AAA74888.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

I51672; I51672.

NP_001084070.1; -.

3D structure databases

HSSP

P54763; 1JPA. [HSSP ENTRY / PDB]

SMR

Q91571; 20-199, 438-529, 593-890.

ModBase

Q91571.

Organism-specific databases

Xenbase

XB-FEAT-488625; ephb1.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0005003;	Molecular function: ephrin receptor activity (inferred from electronic annotation from InterPro).
GO:0006468;	Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
GO:0007169;	Biological process: transmembrane receptor protein tyrosine kinase signaling pathway (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR013032; EGF_like_reg_CS.
IPR001090; Eph_rcpt_lig_bd.
IPR008957; Fibronectin_typ-III-like_fold.
IPR003961; FN_III.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR001660; SAM.
IPR011510; SAM_2.
IPR013761; SAM_type.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
IPR016257; TyrPK_ephrin_receptor.
IPR001426; YKase_receptorV_CS.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.30; FN_III-like; 1.
G3DSA:1.10.150.50; SAM_type; 1.

Pfam

PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000666; TyrPK_ephrin_receptor; 1.

PRINTS

PR00109; TYRKINASE.

ProDom

PD001495; Ephrin_receptor; 1.
PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.

PROSITE

PS01186; EGF_2; UNKNOWN_1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; FALSE_NEG.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q91571.

Genome annotation databases

GeneID

399288; -.

KEGG

xla:399288; -.

Phylogenomic databases

HOVERGEN

Q91571; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`Potential.`
`CHAIN`	`20 985`	`966`	`Ephrin type-B receptor 1-A.`	`PRO_0000016826`
`TOPO_DOM`	`20 542`	`523`	`Extracellular (Potential).`
`TRANSMEM`	`543 563`	`21`	`Potential.`
`TOPO_DOM`	`564 985`	`422`	`Cytoplasmic (Potential).`
`DOMAIN`	`325 426`	`102`	`Fibronectin type-III 1.`
`DOMAIN`	`436 527`	`92`	`Fibronectin type-III 2.`
`DOMAIN`	`620 883`	`264`	`Protein kinase.`
`DOMAIN`	`912 976`	`65`	`SAM.`
`NP_BIND`	`626 634`	`9`	`ATP (By similarity).`
`MOTIF`	`983 985`	`3`	`PDZ-binding (Potential).`
`COMPBIAS`	`185 321`	`137`	`Cys-rich.`
`ACT_SITE`	`745 745`		`Proton acceptor (By similarity).`
`BINDING`	`652 652`		`ATP (By similarity).`
`MOD_RES`	`595 595`		`Phosphotyrosine; by autocatalysis (Potential).`
`MOD_RES`	`601 601`		`Phosphotyrosine; by autocatalysis (Potential).`
`MOD_RES`	`779 779`		`Phosphotyrosine; by autocatalysis (Potential).`
`MOD_RES`	`929 929`		`Phosphotyrosine; by autocatalysis (Potential).`
`CARBOHYD`	`336 336`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`428 428`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`482 482`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 985 AA [This is the length of the unprocessed precursor]

Molecular weight: 110104 Da [This is the MW of the unprocessed precursor]

CRC64: BE72CD1BFF51E623 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MELNVLLLLL CLSGGQVGAV EETLMDTRTA TAELGWTANP SSGWEEVSGY DENLNTIRTY 

        70         80         90        100        110        120 
QVCNVFGPKQ NNWLLTTFIP RRGAHRVYVE MRFTVRDCSS LPNVPGSCKE TFNLYYYETD 

       130        140        150        160        170        180 
SNIENKISTF WNESPYLKVD TIAADESFSQ VDFGGRLMKV NTEVRSFGPL TRSGFYLAFQ 

       190        200        210        220        230        240 
DYGACMSLLS VRVFFKEMPS VVQNLLVFPE TMTGAESTSL VIARGTCIPN AEEVDVPIKL 

       250        260        270        280        290        300 
YCNGDGEWMV PIGKCTCKAG YEPENHVVCK ACPAAMFKAN QGMGICAQCP ANSRSTSEAS 

       310        320        330        340        350        360 
PICICRNGYY RADFDTPEAP CTSVPSGPRN VISIVNETAI TLEWHPPRET GGRDDVDYNI 

       370        380        390        400        410        420 
VCKKCRADRR ACSRCDDNVD FVPRQLGLTD TRVFISNLWA HTPYTFETQA VNGVTNKSPF 

       430        440        450        460        470        480 
PPQHVSVNIT TNQAAPSSVP IMHQVKATMK SITLSWPQQE QPNGIILDYE IRYYEKDHHE 

       490        500        510        520        530        540 
FNSSLARSQT NTARRTGGRV WMFMSVQVRA RTVAGYGKFS SKCGFQTLTA EDYKSELREQ 

       550        560        570        580        590        600 
LPLTGSAAAG VVFIVSLVAI SIVCSRKRTY SKEAVYSDKL QHYSTGRGSP GMKIYIDPFT 

       610        620        630        640        650        660 
YEDPNEAVRE FAKEIDVSFV KIEEVIGAGE FGEVYKGRLK LPSKREISVA IKTLKAGYSE 

       670        680        690        700        710        720 
KQRRDFLSEA SIMGQFDHPN IIRLEGVVTK SRPVMIITEF MENGALDSFL RQNDGQFTVI 

       730        740        750        760        770        780 
QLVGMLRGIA AGMKYLSEMN YVHRDLAARN ILVNSNLVCK VSDFGLSRYL QDDTSDPTYT 

       790        800        810        820        830        840 
SSLGGKIPVR WTAQEAIAYR KFTSASDVWS YGIVMWEVMS YGERPYWTMS NQDVINAIEQ 

       850        860        870        880        890        900 
DYRLPPPMDC PAALHQLMLD CWQKDRNSRP RLAEIVNTLR PMIRNPASLK TVATIPAVPS 

       910        920        930        940        950        960 
QPLLDRSIPD ISAFTSVDDW LSAIKMGQYR DNFLSSGFTS LQLVAQMTSE DLLRIGITLA 

       970        980 
GHQKKILNSI QSMRVQITQS PTSIA

Q91571 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools