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UniProtKB/Swiss-Prot entry Q8Z687

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information

Entry name

DADA_SALTI

Primary accession number

Q8Z687

Secondary accession numbers

None

Integrated into Swiss-Prot on

March 5, 2002

Sequence was last modified on

March 5, 2002 (Sequence version 1)

Annotations were last modified on

November 4, 2008 (Entry version 48)

Name and origin of the protein

Protein name

D-amino acid dehydrogenase small subunit

Synonym

EC 1.4.99.1

Gene name

	Name:	dadA
	OrderedLocusNames:	STY1931, t1074

From

Salmonella typhi

[TaxID: 601]

[HAMAP proteome]

Taxonomy

Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella.

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CT18;
DOI=10.1038/35101607; PubMed=11677608 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.";
Nature 413:848-852(2001).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700931 / Ty2;
DOI=10.1128/JB.185.7.2330-2337.2003; PubMed=12644504 [NCBI, ExPASy, EBI, Israel, Japan]
Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.";
J. Bacteriol. 185:2330-2337(2003).

Comments

FUNCTION: Oxidative deamination of D-amino acids (By similarity).
CATALYTIC ACTIVITY: A D-amino acid + H₂O + acceptor = a 2-oxo acid + NH₃ + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine: step 1/1 .
SUBUNIT: Heterodimer of a small and a large subunit (By similarity).
SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein (By similarity).
SIMILARITY: Belongs to the dadA oxidoreductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AL627272; CAD05486.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014613; AAO68740.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_456310.1; -.
NP_804891.1; -.

3D structure databases

ModBase

Q8Z687.

Enzyme and pathway databases

BioCyc

SENT209261:T1074-MON; -.
SENT220341:STY1931-MON; -.

Ontologies

GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0008718;	Molecular function: D-amino-acid dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006524;	Biological process: alanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_01202; -; 1.
PBIL [Tree]

InterPro

IPR006076; FAD-dep_OxRdtase.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
Graphical view of domain structure.

Pfam

PF01266; DAO; 1.
Pfam graphical view of domain structure.

PRINTS

PR00469; PNDRDTASEII.

ProDom

PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]

ProtoNet

Q8Z687.

Genome annotation databases

GeneID

1070422; -.
1248286; -.

GenomeReviews

AL513382_GR; STY1931.
AE014613_GR; t1074.

KEGG

stt:t1074; -.
sty:STY1931; -.

Phylogenomic databases

HOGENOM

Q8Z687; -.

Genome annotation databases

CMR

Q8Z687; STY1931.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell inner membrane; Cell membrane; Complete proteome; FAD; Flavoprotein; Membrane; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 432`	`432`	`D-amino acid dehydrogenase small subunit.`	`PRO_0000166149`
`NP_BIND`	`3 17`	`15`	`FAD (Potential).`

Sequence information

Length: 432 AA [This is the length of the unprocessed precursor]

Molecular weight: 47952 Da [This is the MW of the unprocessed precursor]

CRC64: 6717E0D8F795F0EB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRVVILGSGV VGVTSAWYLS QAGHDVTVID RESGPAQETS AANAGQISPG YAAPWAAPGV 

        70         80         90        100        110        120 
PLKAIKWMFQ RHAPLAVRLD GTPFQLKWMW QMLRNCDTRH YMENKGRMVR LAEYSRDCLK 

       130        140        150        160        170        180 
TLRAATGIEY EGRQGGTLQL FRTAQQYENA TRDIAVLEDA GVPYQLLEAS RLAEVEPALA 

       190        200        210        220        230        240 
EVAHKLTGGL RLPNDETGDC QLFTQRLARM AEQAGVTFRF NTPVEKLLYE NDQIYGVKCA 

       250        260        270        280        290        300 
DEIIKADAYV MAFGSYSTAM LKGIVDIPVY PLKGYSLTIP IVEPDGAPVS TILDETYKIA 

       310        320        330        340        350        360 
ITRFDKRIRV GGMAEIVGFN TDLLQPRRET LEMVVRDLFP RGGHIEQATF WTGLRPMTPD 

       370        380        390        400        410        420 
GTPVVGRTRY KNLWLNTGHG TLGWTMACGS GQLLSDILLG RTPAIPYDDL SVARYRSDFT 

       430 
PTRPQRLHSA HN

Q8Z687 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools