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UniProtKB/Swiss-Prot entry Q8VIM0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TIMD3_MOUSE
Primary accession number Q8VIM0
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2005
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    May 5, 2009 (Entry version 56)
Name and origin of the protein
Protein name Hepatitis A virus cellular receptor 2 homolog [Precursor]
Synonyms HAVcr-2
T-cell immunoglobulin and mucin domain-containing protein 3
TIMD-3
T-cell membrane protein 3
TIM-3
Gene name
Name: Havcr2
Synonyms: Tim3, Timd3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=DBA/2;
TISSUE=Spleen;
DOI=10.1038/ni739; PubMed=11725301 [NCBI, ExPASy, EBI, Israel, Japan]
McIntire J.J., Umetsu S.E., Akbari O., Potter M., Kuchroo V.K., Barsh G.S., Freeman G.J., Umetsu D.T., DeKruyff R.H.;
"Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.";
Nat. Immunol. 2:1109-1116(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
The mouse genome sequencing consortium;
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
[3]
FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1038/415536a; PubMed=11823861 [NCBI, ExPASy, EBI, Israel, Japan]
Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K.;
"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.";
Nature 415:536-541(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF399831; AAL35776.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL669948; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
IPI IPI00270293; -.
RefSeq NP_599011.2; -.
UniGene Mm.72168
3D structure databases
SMR Q8VIM0; 24-131.
ModBase Q8VIM0.
PTM databases
PhosphoSite Q8VIM0; -.
Organism-specific databases
MGI MGI:2159682; Havcr2.
Gene expression databases
ArrayExpress Q8VIM0; -.
Bgee Q8VIM0; -.
CleanEx MM_HAVCR2; -.
GermOnline ENSMUSG00000020399; Mus musculus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013106; Ig_V-set.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 1.
Pfam PF07686; V-set; 1.
Pfam graphical view of domain structure.
SMART SM00409; IG; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q8VIM0; -.
Genome annotation databases
Ensembl ENSMUSG00000020399; Mus musculus. [Contig view]
GeneID 171285; -.
KEGG mmu:171285; -.
Phylogenomic databases
HOGENOM Q8VIM0; -.
HOVERGEN Q8VIM0; -.
OMA Q8VIM0; PRMLTTK.
Other
NextBio 370963; -.
SOURCE Havcr2; Mus musculus.
ProtoNet Q8VIM0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     Potential. 
CHAIN   20   281  262     Hepatitis A virus cellular receptor 2 homolog. PRO_0000042102
TOPO_DOM   20   193  174     Extracellular (Potential). 
TRANSMEM   194   214  21     Potential. 
TOPO_DOM   215   281  67     Cytoplasmic (Potential). 
DOMAIN   20   125  106     Ig-like V-type. 
COMPBIAS   221   224  4     Poly-Lys. 
CARBOHYD   74    74        N-linked (GlcNAc...) (Potential). 
CARBOHYD   100   100        N-linked (GlcNAc...) (Potential). 
CARBOHYD   172   172        N-linked (GlcNAc...) (Potential). 
DISULFID   38   111        By similarity. 
DISULFID   52    63        By similarity. 
DISULFID   58   110        By similarity. 
Sequence information
Length: 281 AA [This is the length of the unprocessed precursor] Molecular weight: 30934 Da [This is the MW of the unprocessed precursor] CRC64: C0349E4BD0E5761D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFSGLTLNCV LLLLQLLLAR SLENAYVFEV GKNAYLPCSY TLSTPGALVP MCWGKGFCPW 

        70         80         90        100        110        120 
SQCTNELLRT DERNVTYQKS SRYQLKGDLN KGDVSLIIKN VTLDDHGTYC CRIQFPGLMN 

       130        140        150        160        170        180 
DKKLELKLDI KAAKVTPAQT AHGDSTTASP RTLTTERNGS ETQTLVTLHN NNGTKISTWA 

       190        200        210        220        230        240 
DEIKDSGETI RTAIHIGVGV SAGLTLALII GVLILKWYSC KKKKLSSLSL ITLANLPPGG 

       250        260        270        280 
LANAGAVRIR SEENIYTIEE NVYEVENSNE YYCYVNSQQP S 

Q8VIM0 in FASTA format

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