[1]	NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. STRAIN=BALB/c; DOI=10.1016/S0169-328X(98)00183-1; PubMed=9757043 [NCBI, ExPASy, EBI, Israel, Japan] Saito H., Mimmack M.L., Keverne E.B., Kishimoto J., Emson P.C.; "Isolation of mouse vomeronasal receptor genes and their co-localization with specific G-protein messenger RNAs."; Brain Res. Mol. Brain Res. 60:215-227(1998).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1073/pnas.012608399; PubMed=11752409 [NCBI, ExPASy, EBI, Israel, Japan] Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J.; "Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion."; Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Sam M., Matsunami H., Buck L.; "Vomeronasal receptor gene diversity in the mammalian genome."; Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-319. STRAIN=129/SvJ; DOI=10.1101/gr.10.12.1958; PubMed=11116090 [NCBI, ExPASy, EBI, Israel, Japan] Del Punta K., Rothman A., Rodriguez I., Mombaerts P.; "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse."; Genome Res. 10:1958-1967(2000).
[5]	PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE. DOI=10.1038/nature00955; PubMed=12214233 [NCBI, ExPASy, EBI, Israel, Japan] Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.; "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes."; Nature 419:70-74(2002).

Comments

FUNCTION: Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in the apical layer of the vomeronasal organ.
DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Y12725; CAA73257.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF129005; AAG43249.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB062897; BAB79215.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF291481; AAG42075.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00346604; -.

UniGene

Mm.20471

3D structure databases

ModBase

Q8VIC6.

Protein family/group databases

GPCRDB

Q8VIC6; VN1A1_MOUSE.

Organism-specific databases

MGI

MGI:1333759; V1ra1.

Gene expression databases

ArrayExpress

Q8VIC6; -.

Bgee

Q8VIC6; -.

CleanEx

MM_V1RA1; -.
MM_V1RA8; -.

GermOnline

ENSMUSG00000062818; Mus musculus.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016503;	Molecular function: pheromone receptor activity (inferred from electronic annotation from InterPro).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0019236;	Biological process: response to pheromone (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
IPR004072; Vmron_rcpt_1.
Graphical view of domain structure.

PANTHER

PTHR11391; Vmron_rcpt_1; 1.

Pfam

PF03402; V1R; 1.
Pfam graphical view of domain structure.

PRINTS

PR01534; VOMERONASL1R.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSMUSG00000062818; Mus musculus. [Contig view]

Phylogenomic databases

HOVERGEN

Q8VIC6; -.

Other

V1ra1; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Pheromone response; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 319`	`319`	`Vomeronasal type-1 receptor A1.`	`PRO_0000239955`
`TOPO_DOM`	`1 31`	`31`	`Extracellular (Potential).`
`TRANSMEM`	`32 52`	`21`	`1 (Potential).`
`TOPO_DOM`	`53 65`	`13`	`Cytoplasmic (Potential).`
`TRANSMEM`	`66 86`	`21`	`2 (Potential).`
`TOPO_DOM`	`87 109`	`23`	`Extracellular (Potential).`
`TRANSMEM`	`110 130`	`21`	`3 (Potential).`
`TOPO_DOM`	`131 150`	`20`	`Cytoplasmic (Potential).`
`TRANSMEM`	`151 171`	`21`	`4 (Potential).`
`TOPO_DOM`	`172 203`	`32`	`Extracellular (Potential).`
`TRANSMEM`	`204 224`	`21`	`5 (Potential).`
`TOPO_DOM`	`225 254`	`30`	`Cytoplasmic (Potential).`
`TRANSMEM`	`255 275`	`21`	`6 (Potential).`
`TOPO_DOM`	`276 285`	`10`	`Extracellular (Potential).`
`TRANSMEM`	`286 306`	`21`	`7 (Potential).`
`TOPO_DOM`	`307 319`	`13`	`Cytoplasmic (Potential).`
`CARBOHYD`	`175 175`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`101 188`		`By similarity.`
`CONFLICT`	`17 17`		`M -> MM (in Ref. 1; CAA73257).`

Sequence information

Length: 319 AA [This is the length of the unprocessed precursor]

Molecular weight: 36533 Da [This is the MW of the unprocessed precursor]

CRC64: 6F42DE9DBCA02261 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNEILFFSPQ PLFSHMMNEN SRVHTHSNLR HIFFSEIGIG ISGNSFLLLF HILKFIHGHR 

        70         80         90        100        110        120 
SRLSDLPIGL LSLIHLLMLL VMAFIATDIF ISWRGWDDII CKFLVYLYRV LRGLSLCTTS 

       130        140        150        160        170        180 
MLSVLQAIIL SPRSSCLAKF KRKSLHHISC AILFLSVLYM LIGSQLLVSI IATPNLTTND 

       190        200        210        220        230        240 
FIYVTQSCSI LPLSYVMQSM FSTLLVIRDV FLISLMVLST WYMVALLCRH RKKTQHLQGI 

       250        260        270        280        290        300 
SLSPKTSPKQ RATQTLLMLM SFFVLMTIYD TIVSCSRTMF LNDPTSYNMQ IFVVHIYATV 

       310 
SPFVFMSTEK HIVNCLRSV

Q8VIC6 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools