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UniProtKB/Swiss-Prot entry Q8VCX1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AK1D1_MOUSE
Primary accession number Q8VCX1
Secondary accession numbers None
Integrated into Swiss-Prot on June 7, 2005
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name 3-oxo-5-beta-steroid 4-dehydrogenase
Synonyms EC 1.3.1.3
Delta(4)-3-ketosteroid 5-beta-reductase
Delta(4)-3-oxosteroid 5-beta-reductase
Aldo-keto reductase family 1 member D1
Gene name
Name: Akr1d1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC018333; AAH18333.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_663339.1; -.
UniGene Mm.262635
3D structure databases
HSSP P52895; 1J96. [HSSP ENTRY / PDB]
ModBase Q8VCX1.
PTM databases
PhosphoSite Q8VCX1; -.
Organism-specific databases
MGI MGI:2384785; Akr1d1.
Gene expression databases
ArrayExpress Q8VCX1; -.
CleanEx MM_AKR1D1; -.
GermOnline ENSMUSG00000038641; Mus musculus.
Ontologies
GO
GO:0047787; Molecular function: delta4-3-oxosteroid 5beta-reductase activity (inferred from electronic annotation from EC).
GO:0030573; Biological process: bile acid catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001395; Aldo/ket_red.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.100; Aldo/ket_red; 1.
PANTHER PTHR11732; Aldo/ket_red; 1.
Pfam PF00248; Aldo_ket_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00069; ALDKETRDTASE.
ProDom PD000288; Aldo/ket_red; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00798; ALDOKETO_REDUCTASE_1; 1.
PS00062; ALDOKETO_REDUCTASE_2; 1.
PS00063; ALDOKETO_REDUCTASE_3; 1.
ProtoNet Q8VCX1.
Genome annotation databases
Ensembl ENSMUSG00000038641; Mus musculus. [Contig view]
GeneID 208665; -.
KEGG mmu:208665; -.
Phylogenomic databases
HOGENOM Q8VCX1; -.
HOVERGEN Q8VCX1; -.
Other
NextBio 372375; -.
SOURCE Akr1d1; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Bile acid catabolism; Cytoplasm; Lipid metabolism; NADP; Oxidoreductase; Steroid metabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   325  325     3-oxo-5-beta-steroid 4-dehydrogenase. PRO_0000124670
NP_BIND   168   169  2     NADP (By similarity). 
NP_BIND   219   223  5     NADP (By similarity). 
NP_BIND   272   282  11     NADP (By similarity). 
ACT_SITE   57    57        Proton donor (By similarity). 
BINDING   52    52        NADP (By similarity). 
BINDING   192   192        NADP (By similarity). 
BINDING   229   229        Substrate (By similarity). 
Sequence information
Length: 325 AA [This is the length of the unprocessed precursor] Molecular weight: 37290 Da [This is the MW of the unprocessed precursor] CRC64: 1866A0DA4C5DDA98 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNLSAAHHQI SLSDGNNIPL IGLGTYSDPR PVPGKTYVAV KTAIDEGYRH IDGAYVYHNE 

        70         80         90        100        110        120 
HEVGEAIREK IAEGKVKREE IFYCGKLWNT EHVPSMVLPA LERTLKALKL DYIDLYIIEL 

       130        140        150        160        170        180 
PMAFKPGKEI YPRDENGRII YDKTNLCATW EALEACKDAG LVKSLGVSNF NRRQLELILN 

       190        200        210        220        230        240 
KPGLKYKPVT NQVECHPYFT QTKLLKFCQQ HDIVIVAHSP LGTCRNPSWV NVSSPPLLND 

       250        260        270        280        290        300 
ELLTSLGKKY NKTQAQIVLR FNIQRGIVVI PKSFTPERIK ENFQIFDFSL TEEEMKDIDA 

       310        320 
LNKNVRYVEL LMWSDHPEYP FHDEY
Q8VCX1 in FASTA format

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