[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1073/pnas.1732949100; PubMed=12909716 [NCBI, ExPASy, EBI, Israel, Japan] Zylka M.J., Dong X., Southwell A.L., Anderson D.J.; "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family."; Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
[2]	NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND POSSIBLE FUNCTION. TISSUE=Liver; DOI=10.1074/jbc.M314240200; PubMed=15037633 [NCBI, ExPASy, EBI, Israel, Japan] Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H., Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T., Moriya T., Itoh Y., Hinuma S.; "Identification of a G protein-coupled receptor specifically responsive to beta-alanine."; J. Biol. Chem. 279:23559-23564(2004).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1016/S0014-5793(02)02775-8; PubMed=12044878 [NCBI, ExPASy, EBI, Israel, Japan] Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; "Identification of G protein-coupled receptor genes from the human genome sequence."; FEBS Lett. 520:97-101(2002).
[4]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas subfamily [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY427820; AAR05120.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB154410; BAD20638.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB083627; BAB89340.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB065786; BAC06005.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00447219; -.

NP_944605.2; -.

3D structure databases

ModBase

Q8TDS7.

Protein family/group databases

GPCRDB

Q8TDS7; MRGRD_HUMAN.

Organism-specific databases

GC11M068504; -.

HIX0035840; -.

HGNC:29626; MRGPRD.

607231; gene. [NCBI / EBI]

PharmGKB

PA134978563; -.

Gene expression databases

ArrayExpress

Q8TDS7; -.

Bgee

Q8TDS7; -.

CleanEx

HS_MRGPRD; -.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004930;	Molecular function: G-protein coupled receptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00237; GPCRRHODOPSN.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q8TDS7; -.

Genome annotation databases

Ensembl

ENSG00000172938; Homo sapiens. [Contig view]

GeneID

116512; -.

KEGG

hsa:116512; -.

Phylogenomic databases

HOGENOM

Q8TDS7; -.

HOVERGEN

Q8TDS7; -.

OMA

Q8TDS7; DKVHELM.

Other

NextBio

79958; -.

SOURCE

MRGPRD; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 321`	`321`	`Mas-related G-protein coupled receptor member D.`	`PRO_0000069756`
`TOPO_DOM`	`1 33`	`33`	`Extracellular (Potential).`
`TRANSMEM`	`34 54`	`21`	`1 (Potential).`
`TOPO_DOM`	`55 59`	`5`	`Cytoplasmic (Potential).`
`TRANSMEM`	`60 80`	`21`	`2 (Potential).`
`TOPO_DOM`	`81 112`	`32`	`Extracellular (Potential).`
`TRANSMEM`	`113 133`	`21`	`3 (Potential).`
`TOPO_DOM`	`134 142`	`9`	`Cytoplasmic (Potential).`
`TRANSMEM`	`143 163`	`21`	`4 (Potential).`
`TOPO_DOM`	`164 184`	`21`	`Extracellular (Potential).`
`TRANSMEM`	`185 205`	`21`	`5 (Potential).`
`TOPO_DOM`	`206 218`	`13`	`Cytoplasmic (Potential).`
`TRANSMEM`	`219 239`	`21`	`6 (Potential).`
`TOPO_DOM`	`240 257`	`18`	`Extracellular (Potential).`
`TRANSMEM`	`258 280`	`23`	`7 (Potential).`
`TOPO_DOM`	`281 321`	`41`	`Cytoplasmic (Potential).`
`CARBOHYD`	`2 2`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`6 6`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`16 16`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`92 92`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 321 AA [This is the length of the unprocessed precursor]

Molecular weight: 36118 Da [This is the MW of the unprocessed precursor]

CRC64: B45AB7FEB2154B40 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNQTLNSSGT VESALNYSRG STVHTAYLVL SSLAMFTCLC GMAGNSMVIW LLGFRMHRNP 

        70         80         90        100        110        120 
FCIYILNLAA ADLLFLFSMA STLSLETQPL VNTTDKVHEL MKRLMYFAYT VGLSLLTAIS 

       130        140        150        160        170        180 
TQRCLSVLFP IWFKCHRPRH LSAWVCGLLW TLCLLMNGLT SSFCSKFLKF NEDRCFRVDM 

       190        200        210        220        230        240 
VQAALIMGVL TPVMTLSSLT LFVWVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLSIY 

       250        260        270        280        290        300 
WFVLYWLSLP PEMQVLCFSL SRLSSSVSSS ANPVIYFLVG SRRSHRLPTR SLGTVLQQAL 

       310        320 
REEPELEGGE TPTVGTNEMG A

Q8TDS7 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools