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UniProtKB/Swiss-Prot entry Q8N441


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FGRL1_HUMAN
Primary accession number Q8N441
Secondary accession numbers B2RAU9 Q6PJN1 Q9BXN7 Q9H4D7
Integrated into Swiss-Prot on June 21, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 59)
Name and origin of the protein
Protein name Fibroblast growth factor receptor-like 1 [Precursor]
Synonyms FGF receptor-like protein 1
Fibroblast growth factor receptor 5
FGFR-like protein
FGF homologous factor receptor
Gene name
Name: FGFRL1
Synonyms: FGFR5, FHFR
ORFNames: UNQ480/PRO943
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT GLN-362.
TISSUE=Cartilage;
DOI=10.1006/geno.2000.6332; PubMed=11031111 [NCBI, ExPASy, EBI, Israel, Japan]
Wiedemann M., Trueb B.;
"Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors.";
Genomics 69:275-279(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT GLN-362.
DOI=10.1016/S0167-4781(00)00282-7; PubMed=11267671 [NCBI, ExPASy, EBI, Israel, Japan]
Kim I., Moon S.-O., Yu K.-H., Kim U.-H., Koh G.Y.;
"A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas.";
Biochim. Biophys. Acta 1518:152-156(2001).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Aggarwal S., Xie M.-H., Foster J., Frantz G., Stinson J., Corpuz R.T., Simmons L., Hillan K., Yansura D.G., Vandlen R.L., Goddard A.D., Gurney A.L.;
"FHFR, a novel fibroblast growth factor receptor that uniquely binds the fibroblast growth factor homologous factors.";
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-362.
TISSUE=Brain, and Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 25-39.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[8]
TISSUE SPECIFICITY.
DOI=10.1016/S0378-1119(01)00518-2; PubMed=11418238 [NCBI, ExPASy, EBI, Israel, Japan]
Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G.;
"Identification of a new fibroblast growth factor receptor, FGFR5.";
Gene 271:171-182(2001).
[9]
SUBCELLULAR LOCATION.
TISSUE=Cartilage;
DOI=10.1074/jbc.M300281200; PubMed=12813049 [NCBI, ExPASy, EBI, Israel, Japan]
Trueb B., Zhuang L., Taeschler S., Wiedemann M.;
"Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues.";
J. Biol. Chem. 278:33857-33865(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ277437; CAC14171.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF279689; AAK26742.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF312678; AAK15273.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358303; AAQ88670.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK314365; BAG36996.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013955; AAH13955.2; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC036769; AAH36769.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00296561; -.
RefSeq NP_001004356.1; -.
NP_001004358.1; -.
NP_068742.2; -.
UniGene Hs.193326
3D structure databases
HSSP Q9UQH9; 1EV2. [HSSP ENTRY / PDB]
ModBase Q8N441.
Organism-specific databases
GeneCards GC04P000996; -.
H-InvDB HIX0004011; -.
HIX0060458; -.
HGNC HGNC:3693; FGFRL1.
GenAtlas FGFRL1.
MIM 605830; gene. [NCBI / EBI]
PharmGKB PA28132; -.
Gene expression databases
ArrayExpress Q8N441; -.
Bgee Q8N441; -.
CleanEx HS_FGFRL1; -.
GermOnline ENSG00000127418; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0005007; Molecular function: fibroblast growth factor receptor activity (non-traceable author statement from UniProtKB).
GO:0001558; Biological process: regulation of cell growth (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 3.
Pfam PF07679; I-set; 3.
Pfam graphical view of domain structure.
SMART SM00409; IG; 1.
SM00408; IGc2; 2.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 3.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas Q8N441; -.
PRIDE Q8N441; -.
Genome annotation databases
Ensembl ENSG00000127418; Homo sapiens. [Contig view]
GeneID 53834; -.
KEGG hsa:53834; -.
Phylogenomic databases
HOGENOM Q8N441; -.
HOVERGEN Q8N441; -.
OMA Q8N441; TLIVMDD.
Other
NextBio 56170; -.
SOURCE FGFRL1; Homo sapiens.
ProtoNet Q8N441.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    24  24      
CHAIN   25   504  480     Fibroblast growth factor receptor-like 1. PRO_0000021250
TOPO_DOM   25   378  354     Extracellular (Potential). 
TRANSMEM   379   399  21     Potential. 
TOPO_DOM   400   504  105     Cytoplasmic (Potential). 
DOMAIN   29   115  87     Ig-like C2-type 1. 
DOMAIN   147   237  91     Ig-like C2-type 2. 
DOMAIN   246   354  109     Ig-like C2-type 3. 
COMPBIAS   479   501  23     His-rich. 
CARBOHYD   111   111        N-linked (GlcNAc...) (Potential). 
CARBOHYD   231   231        N-linked (GlcNAc...) (Potential). 
CARBOHYD   255   255        N-linked (GlcNAc...) (Potential). 
CARBOHYD   293   293        N-linked (GlcNAc...) (Potential). 
DISULFID   51    99        By similarity. 
DISULFID   172   221        By similarity. 
DISULFID   268   338        By similarity. 
VARIANT   362   362  1     P -> Q (in dbSNP:rs4647930 [NCBI]). VAR_022642 
VARIANT   464   464  1     P -> L (in dbSNP:rs4647932 [NCBI]). VAR_024316 
CONFLICT   374   380        Missing (in Ref. 3; AAK15273). 
Sequence information
Length: 504 AA [This is the length of the unprocessed precursor] Molecular weight: 54537 Da [This is the MW of the unprocessed precursor] CRC64: 56E35E57D5FC141B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ CPVEGDPPPL 

        70         80         90        100        110        120 
TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK ATNGFGSLSV NYTLVVLDDI 

       130        140        150        160        170        180 
SPGKESLGPD SSSGGQEDPA SQQWARPRFT QPSKMRRRVI ARPVGSSVRL KCVASGHPRP 

       190        200        210        220        230        240 
DITWMKDDQA LTRPEAAEPR KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ 

       250        260        270        280        290        300 
RTRSKPVLTG THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG 

       310        320        330        340        350        360 
QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS AFLTVLPDPK 

       370        380        390        400        410        420 
PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ AQKKPCTPAP APPLPGHRPP 

       430        440        450        460        470        480 
GTARDRSGDK DLPSLAALSA GPGVGLCEEH GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT 

       490        500 
HTHTHSHTHS HVEGKVHQHI HYQC 

Q8N441 in FASTA format

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