[1]	NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION. STRAIN=BALB/c; TISSUE=Kidney; DOI=10.1016/S1074-7613(02)00283-2; PubMed=11911831 [NCBI, ExPASy, EBI, Israel, Japan] Migone T.-S., Zhang J., Luo X., Zhuang L., Chen C., Hu B., Hong J.S., Perry J.W., Chen S.-F., Zhou J.X.H., Cho Y.H., Ullrich S., Kanakaraj P., Carrell J., Boyd E., Olsen H.S., Hu G., Pukac L., Liu D., Ni J., Kim S., Gentz R., Feng P., Moore P.A., Ruben S.M., Wei P.; "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator."; Immunity 16:479-492(2002).
[2]	NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION. STRAIN=C57BL/6; PubMed=15702971 [NCBI, ExPASy, EBI, Israel, Japan] Xiao Q., Hsu C.Y., Chen H., Ma X., Xu J., Lee J.-M.; "Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter."; Biochem. J. 388:913-920(2005).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=C3H/He; TISSUE=Osteoblast; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis (By similarity). Promotes splenocyte alloactivation.
SUBUNIT: Homotrimer (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Probable).
INDUCTION: Up-regulated by TNF-alpha.
SIMILARITY: Belongs to the tumor necrosis factor family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF520786; AAM77367.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY764130; AAV33431.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096494; AAH96494.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00330923; -.

NP_796345.2; -.

3D structure databases

ModBase

Q5UBV8.

Organism-specific databases

MGI

MGI:2180140; Tnfsf15.

Ontologies

GO:0005615;	Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005125;	Molecular function: cytokine activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005164;	Molecular function: tumor necrosis factor receptor binding (inferred from electronic annotation from InterPro).
GO:0006955;	Biological process: immune response (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR006053; TNF_abc.
IPR006052; TNF_family.
IPR008983; Tumour_necrosis_fac-like.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1.

Pfam

PF00229; TNF; 1.
Pfam graphical view of domain structure.

PRINTS

PR01234; TNECROSISFCT.

ProDom

PD002012; TNF_subf; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00207; TNF; 1.
SMART graphical view of domain structure.

PROSITE

PS50049; TNF_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q5UBV8; -.

Genome annotation databases

Ensembl

ENSMUSG00000050395; Mus musculus. [Contig view]

GeneID

326623; -.

KEGG

mmu:326623; -.

Other

NextBio

397918; -.

SOURCE

Tnfsf15; Mus musculus.

ProtoNet

Q5UBV8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytokine; Disulfide bond; Glycoprotein; Membrane; Signal-anchor; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 252`	`252`	`Tumor necrosis factor ligand superfamily member 15.`	`PRO_0000333232`
`TOPO_DOM`	`1 39`	`39`	`Cytoplasmic (Potential).`
`TRANSMEM`	`40 60`	`21`	`Signal-anchor for type II membrane protein (Potential).`
`TOPO_DOM`	`61 252`	`192`	`Extracellular (Potential).`
`CARBOHYD`	`137 137`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`230 230`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`163 203`		`By similarity.`
`CONFLICT`	`180 180`		`V -> M (in Ref. 2; AAV33431 and 3; AAH96494).`
`CONFLICT`	`218 218`		`M -> T (in Ref. 2; AAV33431 and 3; AAH96494).`

Sequence information

Length: 252 AA [This is the length of the unprocessed precursor]

Molecular weight: 27723 Da [This is the MW of the unprocessed precursor]

CRC64: BB901C9350119E0F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAEELGLGFG EGVPVEVLPE GCRHRPEARA GLAARSKACL ALTCCLLSFP ILAGLSTLLM 

        70         80         90        100        110        120 
AGQLRVPGKD CMLRAITEER SEPSPQQVYS PPRGKPRAHL TIKKQTPAPH LKNQLSALHW 

       130        140        150        160        170        180 
EHDLGMAFTK NGMKYINKSL VIPESGDYFI YSQITFRGTT SVCGDISRGR RPNKPDSITV 

       190        200        210        220        230        240 
VITKVADSYP EPARLLTGSK SVCEISNNWF QSLYLGAMFS LEEGDRLMVN VSDISLVDYT 

       250 
KEDKTFFGAF LL

Q5UBV8 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools