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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=ILS, and ISS;
DOI=10.1007/s00335-001-1001-x; PubMed=11471062 [NCBI, ExPASy, EBI, Israel, Japan]
Ehringer M.A.,
Thompson J.,
Conroy O.,
Xu Y.,
Yang F.,
Canniff J.,
Beeson M.,
Gordon L.,
Bennett B.,
Johnson T.E.,
Sikela J.M.;
"High-throughput sequence identification of gene coding variants within alcohol-related QTLs.";
Mamm. Genome 12:657-663(2001).
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[2]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, AND MASS SPECTROMETRY.
TISSUE=Brain;
DOI=10.1074/mcp.T500041-MCP200; PubMed=16452087 [NCBI, ExPASy, EBI, Israel, Japan]
Trinidad J.C.,
Specht C.G.,
Thalhammer A.,
Schoepfer R.,
Burlingame A.L.;
"Comprehensive identification of phosphorylation sites in postsynaptic density preparations.";
Mol. Cell. Proteomics 5:914-922(2006).
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[3]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461 AND SER-469, AND MASS SPECTROMETRY.
TISSUE=Brain cortex;
DOI=10.1074/mcp.M600046-MCP200; PubMed=17114649 [NCBI, ExPASy, EBI, Israel, Japan]
Munton R.P.,
Tweedie-Cullen R.,
Livingstone-Zatchej M.,
Weinandy F.,
Waidelich M.,
Longo D.,
Gehrig P.,
Potthast F.,
Rutishauser D.,
Gerrits B.,
Panse C.,
Schlapbach R.,
Mansuy I.M.;
"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.";
Mol. Cell. Proteomics 6:283-293(2007).
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- FUNCTION: May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity).
- SUBUNIT: Interacts with CAPON (By similarity).
- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles (By similarity).
- MISCELLANEOUS: Regulated by calcium. Calcium inhibits ATP binding to the C-domain (By similarity).
- SIMILARITY: Belongs to the synapsin family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 579 AA [This is the length of the unprocessed precursor] |
Molecular weight: 63345 Da [This is the MW of the unprocessed precursor] |
CRC64: 2B84E6B283A3D50F [This is a checksum on the sequence] |
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10 20 30 40 50 60
MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA SFSSPGSSLF
70 80 90 100 110 120
SSFSSAMKQT PQAPSGLMEP PTPVTPVVQR PRILLVIDDA HTDWSKYFHG KKVNGDIEIR
130 140 150 160 170 180
VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV
190 200 210 220 230 240
IGLQYGGLPA VNSLYSVYNF CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP
250 260 270 280 290 300
NFPVVIKLGH AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN
310 320 330 340 350 360
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV KAVHSKDGRD
370 380 390 400 410 420
YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA TVPSPLRPWG PQTKPAKSPG
430 440 450 460 470 480
QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS
490 500 510 520 530 540
PGSPQLSRAS GGSSPNQASK PSASLSSHNR PPVQGRSTSQ QGEEPQKSAS PHPHLNKSQS
550 560 570
LTNSLSTSDT SHRGTPSEDE AKAETIRNLR KSFASLFSD
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Q8JZP2 in FASTA format |
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ExPASy Home page
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