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UniProtKB/Swiss-Prot entry Q8IWJ2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GCC2_HUMAN
Primary accession number Q8IWJ2
Secondary accession numbers O15045 Q4ZG46 Q8TDH3 Q9H2G8
Integrated into Swiss-Prot on July 3, 2003
Sequence was last modified on October 2, 2007 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 70)
Name and origin of the protein
Protein name GRIP and coiled-coil domain-containing protein 2
Synonyms Golgi coiled-coil protein GCC185
Ran-binding protein 2-like 4
RanBP2L4
CTCL tumor antigen se1-1
CLL-associated antigen KW-11
Renal carcinoma antigen NY-REN-53
Gene name
Name: GCC2
Synonyms: KIAA0336, RANBP2L4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLU-1033.
TISSUE=Brain;
DOI=10.1093/dnares/4.2.141; PubMed=9205841 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.";
DNA Res. 4:141-150(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-347 (ISOFORM 2).
DOI=10.1182/blood-2002-02-0513; PubMed=12200376 [NCBI, ExPASy, EBI, Israel, Japan]
Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G.;
"Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.";
Blood 100:2123-2131(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-349 (ISOFORM 1).
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 60-839, AND TISSUE SPECIFICITY.
TISSUE=Testis;
DOI=10.1073/pnas.021386498; PubMed=11149944 [NCBI, ExPASy, EBI, Israel, Japan]
Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.;
"Serological detection of cutaneous T-cell lymphoma-associated antigens.";
Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).
[6]
IDENTIFICATION AS A RENAL CANCER ANTIGEN.
TISSUE=Renal cell carcinoma;
DOI=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5; PubMed=10508479 [NCBI, ExPASy, EBI, Israel, Japan]
Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J.;
"Antigens recognized by autologous antibody in patients with renal-cell carcinoma.";
Int. J. Cancer 83:456-464(1999).
[7]
SUBCELLULAR LOCATION.
DOI=10.1074/jbc.M210387200; PubMed=12446665 [NCBI, ExPASy, EBI, Israel, Japan]
Luke M.R., Kjer-Nielsen L., Brown D.L., Stow J.L., Gleeson P.A.;
"GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network.";
J. Biol. Chem. 278:4216-4226(2003).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1382, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186 AND SER-1548, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1382; SER-1441 AND SER-1548, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB002334; BAA20794.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC012487; AAX88838.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC068941; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AF432211; AAL99918.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC037774; AAH37774.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF273042; AAG34902.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00005631; -.
IPI00333197; -.
RefSeq NP_055450.1; -.
NP_852118.1; -.
UniGene Hs.436505
3D structure databases
PDB
3BBP; X-ray; 3.00 A; D/E/F=1446-1511.[ExPASy / RCSB / EBI]
PDBsum 3BBP; -.
ModBase Q8IWJ2.
Protein-protein interaction databases
IntAct Q8IWJ2; 6.
PTM databases
PhosphoSite Q8IWJ2; -.
Organism-specific databases
GeneCards GC02P108524; -.
H-InvDB HIX0022004; -.
HIX0023314; -.
HGNC HGNC:23218; GCC2.
GenAtlas GCC2.
PharmGKB PA134876902; -.
HUGE KIAA0336.
Gene expression databases
Bgee Q8IWJ2; -.
CleanEx HS_GCC2; -.
GermOnline ENSG00000135968; Homo sapiens.
Ontologies
GO
GO:0000139; Cellular component: Golgi membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0042802; Molecular function: identical protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR000237; GRIP.
Graphical view of domain structure.
Pfam PF01465; GRIP; 1.
Pfam graphical view of domain structure.
SMART SM00755; Grip; 1.
SMART graphical view of domain structure.
PROSITE PS50913; GRIP; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q8IWJ2; -.
Genome annotation databases
Ensembl ENSG00000135968; Homo sapiens. [Contig view]
GeneID 9648; -.
KEGG hsa:9648; -.
Phylogenomic databases
HOGENOM Q8IWJ2; -.
HOVERGEN Q8IWJ2; -.
Other
NextBio 36215; -.
ProtoNet Q8IWJ2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Coiled coil; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1583  1583     GRIP and coiled-coil domain-containing protein 2. PRO_0000190074
DOMAIN   1508   1558  51     GRIP. 
COILED   9   1517  1509     Potential. 
COMPBIAS   138    947  810     Glu-rich. 
MOD_RES   186    186        Phosphoserine. 
MOD_RES   1382   1382        Phosphoserine. 
MOD_RES   1441   1441        Phosphoserine. 
MOD_RES   1548   1548        Phosphoserine. 
VAR_SEQ   1      1        M -> MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMML IQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDA LLLEKAETEQQCLSLKKENIKM (in isoform 2). VSP_007733
VARIANT   1033   1033  1     Q -> E (in dbSNP:rs2718698 [NCBI]). VAR_046635 
VARIANT   1197   1197  1     R -> G (in dbSNP:rs1061202 [NCBI]). VAR_016101 
CONFLICT   593    599        NNKLSSE -> TINSVQK (in Ref. 5; AAG34902). 
CONFLICT   836    839        SVKN -> YCKK (in Ref. 5; AAG34902). 
HELIX   1473   1504  32      
Sequence information
Length: 1583 AA [This is the length of the unprocessed precursor] Molecular weight: 184657 Da [This is the MW of the unprocessed precursor] CRC64: 65D503FAE5969494 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKQEVEDSVT KMGDAHKELE QSHINYVKEI ENLKNELMAV RSKYSEDKAN LQKQLEEAMN 

        70         80         90        100        110        120 
TQLELSEQLK FQNNSEDNVK KLQEEIEKIR PGFEEQILYL QKQLDATTDE KKETVTQLQN 

       130        140        150        160        170        180 
IIEANSQHYQ KNINSLQEEL LQLKAIHQEE VKELMCQIEA SAKEHEAEIN KLNELKENLV 

       190        200        210        220        230        240 
KQCEASEKNI QKKYECELEN LRKATSNANQ DNQICSILLQ ENTFVEQVVN EKVKHLEDTL 

       250        260        270        280        290        300 
KELESQHSIL KDEVTYMNNL KLKLEMDAQH IKDEFFHERE DLEFKINELL LAKEEQGCVI 

       310        320        330        340        350        360 
EKLKSELAGL NKQFCYTVEQ HNREVQSLKE QHQKEISELN ETFLSDSEKE KLTLMFEIQG 

       370        380        390        400        410        420 
LKEQCENLQQ EKQEAILNYE SLREIMEILQ TELGESAGKI SQEFESMKQQ QASDVHELQQ 

       430        440        450        460        470        480 
KLRTAFTEKD ALLETVNRLQ GENEKLLSQQ ELVPELENTI KNLQEKNGVY LLSLSQRDTM 

       490        500        510        520        530        540 
LKELEGKINS LTEEKDDFIN KLKNSHEEMD NFHKKCEREE RLILELGKKV EQTIQYNSEL 

       550        560        570        580        590        600 
EQKVNELTGG LEETLKEKDQ NDQKLEKLMV QMKVLSEDKE VLSAEVKSLY EENNKLSSEK 

       610        620        630        640        650        660 
KQLSRDLEVF LSQKEDVILK EHITQLEKKL QLMVEEQDNL NKLLENEQVQ KLFVKTQLYG 

       670        680        690        700        710        720 
FLKEMGSEVS EDSEEKDVVN VLQAVGESLA KINEEKCNLA FQRDEKVLEL EKEIKCLQEE 

       730        740        750        760        770        780 
SVVQCEELKS LLRDYEQEKV LLRKELEEIQ SEKEALQSDL LEMKNANEKT RLENQNLLIQ 

       790        800        810        820        830        840 
VEEVSQTCSK SEIHNEKEKC FIKEHENLKP LLEQKELRDR RAELILLKDS LAKSPSVKND 

       850        860        870        880        890        900 
PLSSVKELEE KIENLEKECK EKEEKINKIK LVAVKAKKEL DSSRKETQTV KEELESLRSE 

       910        920        930        940        950        960 
KDQLSASMRD LIQGAESYKN LLLEYEKQSE QLDVEKERAN NFEHRIEDLT RQLRNSTLQC 

       970        980        990       1000       1010       1020 
ETINSDNEDL LARIETLQSN AKLLEVQILE VQRAKAMVDK ELEAEKLQKE QKIKEHATTV 

      1030       1040       1050       1060       1070       1080 
NELEELQVQL QKQKKQLQKT MQELELVKKD AQQTTLMNME IADYERLMKE LNQKLTNKNN 

      1090       1100       1110       1120       1130       1140 
KIEDLEQEIK IQKQKQETLQ EEITSLQSSV QQYEEKNTKI KQLLVKTKKE LADSKQAETD 

      1150       1160       1170       1180       1190       1200 
HLILQASLKG ELEASQQQVE VYKIQLAEIT SEKHKIHEHL KTSAEQHQRT LSAYQQRVTA 

      1210       1220       1230       1240       1250       1260 
LQEECRAAKA EQATVTSEFE SYKVRVHNVL KQQKNKSMSQ AETEGAKQER EHLEMLIDQL 

      1270       1280       1290       1300       1310       1320 
KIKLQDSQNN LQINVSELQT LQSEHDTLLE RHNKMLQETV SKEAELREKL CSIQSENMMM 

      1330       1340       1350       1360       1370       1380 
KSEHTQTVSQ LTSQNEVLRN SFRDQVRHLQ EEHRKTVETL QQQLSKMEAQ LFQLKNEPTT 

      1390       1400       1410       1420       1430       1440 
RSPVSSQQSL KNLRERRNTD LPLLDMHTVT REEGEGMETT DTESVSSAST YTQSLEQLLN 

      1450       1460       1470       1480       1490       1500 
SPETKLEPPL WHAEFTKEEL VQKLSSTTKS ADHLNGLLRE TEATNAILME QIKLLKSEIR 

      1510       1520       1530       1540       1550       1560 
RLERNQEREK SAANLEYLKN VLLQFIFLKP GSERERLLPV INTMLQLSPE EKGKLAAVAQ 

      1570       1580 
GEEENASRSS GWASYLHSWS GLR 

Q8IWJ2 in FASTA format

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