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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryo;
DOI=10.1093/hmg/ddg087; PubMed=12651873 [NCBI, ExPASy, EBI, Israel, Japan]
Hurle B.,
Ignatova E.,
Massironi S.M.,
Mashimo T.,
Rios X.,
Thalmann I.,
Thalmann R.,
Ornitz D.M.;
"Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.";
Hum. Mol. Genet. 12:777-789(2003).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, AND CHARACTERIZATION OF MUTANT VAL-429.
DOI=10.1007/s00427-004-0440-2; PubMed=15480759 [NCBI, ExPASy, EBI, Israel, Japan]
Soellner C.,
Schwarz H.,
Geisler R.,
Nicolson T.;
"Mutated otopetrin 1 affects the genesis of otoliths and the localization of Starmaker in zebrafish.";
Dev. Genes Evol. 214:582-590(2004).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Larva;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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[4]
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FUNCTION, DISEASE, AND DEVELOPMENTAL STAGE.
DOI=10.1016/j.ydbio.2004.09.001; PubMed=15581873 [NCBI, ExPASy, EBI, Israel, Japan]
Hughes I.,
Blasiole B.,
Huss D.,
Warchol M.E.,
Rath N.P.,
Hurle B.,
Ignatova E.,
Dickman J.D.,
Thalmann R.,
Levenson R.,
Ornitz D.M.;
"Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.";
Dev. Biol. 276:391-402(2004).
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- FUNCTION: Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity). Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration.
- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Secreted, extracellular space (By similarity).
- DEVELOPMENTAL STAGE: First detected in the otic placode at 16.5 hours post-fertilization (hpf). Detected in the developing inner ear sensory epithelium at 24 hpf. Detected in hair cells of the sensory epithelium at 4 days post-fertilization (dpf). At 5 dpf, levels are much reduced in the otolith organs, and not detectable at 7 dpf. Detected in neuromasts and in the lateral line system at 5 dpf and 7 dpf.
- MISCELLANEOUS: Fishes lacking otop1 display the backstroke phenotype. Mutant fish exhibit otolith agenesis without additional effects on the sensory epithelium or other inner ear structures. Otoliths are essential for the perception of gravity and acceleration. Larvae without otoliths are unable to orient dorsal side up and rest mostly on their side in contact with the ground.
- MISCELLANEOUS: Otoliths are structures composed of proteins and calcium carbonate that are found in the fish inner ear in contact with the otic epithelium. They are essential for the perception of gravity and acceleration.
- SIMILARITY: Belongs to the otopetrin family.
- WEB RESOURCE: Name=Protein Spotlight; Note=Ear of stone - Issue 89 of December 2007; URL="http://www.expasy.org/spotlight/back_issues/sptlt089.shtml";.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 586 AA [This is the length of the unprocessed precursor] |
Molecular weight: 65721 Da [This is the MW of the unprocessed precursor] |
CRC64: 000ED7A4E690831E [This is a checksum on the sequence] |
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10 20 30 40 50 60
MVEHGGTDSM WLNKYNPAAA SSASSSSSSD AENKLFSRLK VSLTKKYPQK NAELLSAQYG
70 80 90 100 110 120
TNLLLLGVSV MLALAAQSGP VKEEHLLSFI TVLMLVQLVW MLCYMIRRER ERSPVPERDA
130 140 150 160 170 180
HAGASWIRGG LTMLALLSLI MDAFRIGYFV GYHSCISAAL GVYPIVHALH TISQVHFLWF
190 200 210 220 230 240
HIKDVIKKYE TFERFGVIHA VFTNLLLWCN GVMSETEHFM HNHRRRLIEM GYANLSTVDV
250 260 270 280 290 300
QPHCNCTTSV CSMFSTSLYY LYPFNIEYHI FVSAMLFVMW KNIGRTLDRH SNRKRRSTGS
310 320 330 340 350 360
TGLLLGPLGG LVALASSVSV LVVYLIHLEK TEEMHEAAVS MFYYYGVAMM ACMCVGSGTG
370 380 390 400 410 420
LLVYRMENRP MDTGSNPART LDTELLLASS LGSWLMSWCS VVASVAEAGQ KSPSFSWTSL
430 440 450 460 470 480
TYSLLLVLEK CIQNLFIVES LYRRHSEEEE DAAAPQVFSV AVPPYDGILN HGYEAHDKHR
490 500 510 520 530 540
EAEPAAGSHA LSRKQPDAPL PAGQRLDVTP GRKRQILKNI CMFLFMCNIS LWILPAFGCR
550 560 570 580
PQYDNPLENE TFGTSVWTTV LNVAIPLNLF YRMHSVASLF EVFRKV
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Q7ZWK8 in FASTA format |
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