[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/S0960-9822(02)00909-0; PubMed=12123587 [NCBI, ExPASy, EBI, Israel, Japan] Rodriguez I., Mombaerts P.; "Novel human vomeronasal receptor-like genes reveal species-specific families."; Curr. Biol. 12:R409-R411(2002).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-350. DOI=10.1073/pnas.1331721100; PubMed=12826614 [NCBI, ExPASy, EBI, Israel, Japan] Zhang J., Webb D.M.; "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."; Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1016/S0014-5793(02)02775-8; PubMed=12044878 [NCBI, ExPASy, EBI, Israel, Japan] Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; "Identification of G protein-coupled receptor genes from the human genome sequence."; FEBS Lett. 520:97-101(2002).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Putative pheromone receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
POLYMORPHISM: There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.
MISCELLANEOUS: The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].
WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of August 2005; URL="http://www.expasy.org/spotlight/back_issues/sptlt061.shtml";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY114735; AAM66756.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY312489; AAP85622.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY312490; -; NOT_ANNOTATED_CDS; Genomic_DNA.	[EMBL / GenBank / DDBJ]
AY312491; AAP85623.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB083608; BAB89321.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC126341; AAI26342.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC126367; AAI26368.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00168753; -.

NP_776257.1; -.

3D structure databases

ModBase

Q7Z5H4.

Protein family/group databases

GPCRDB

Q7Z5H4; VN1R5_HUMAN.

PTM databases

PhosphoSite

Q7Z5H4; -.

Organism-specific databases

GeneCards

GC01P245485; -.

H-InvDB

HIX0029586; -.
HIX0029720; -.

HGNC:19870; VN1R5.

PA134993066; -.

Gene expression databases

CleanEx

HS_VN1R5; -.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016503;	Molecular function: pheromone receptor activity (inferred from electronic annotation from InterPro).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0019236;	Biological process: response to pheromone (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR004072; Vmron_rcpt_1.
Graphical view of domain structure.

PANTHER

PTHR11391; Vmron_rcpt_1; 1.

Pfam

PF03402; V1R; 1.
Pfam graphical view of domain structure.

PRINTS

PR01534; VOMERONASL1R.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
PS50262; G_PROTEIN_RECEP_F1_2; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSG00000197617; Homo sapiens. [Contig view]

GeneID

317705; -.

KEGG

hsa:317705; -.

Phylogenomic databases

HOVERGEN

Q7Z5H4; -.

Other

96372; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Pheromone response; Polymorphism; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 357`	`357`	`Vomeronasal type-1 receptor 5.`	`PRO_0000070220`
`TOPO_DOM`	`1 3`	`3`	`Extracellular (Potential).`
`TRANSMEM`	`4 24`	`21`	`1 (Potential).`
`TOPO_DOM`	`25 52`	`28`	`Cytoplasmic (Potential).`
`TRANSMEM`	`53 73`	`21`	`2 (Potential).`
`TOPO_DOM`	`74 81`	`8`	`Extracellular (Potential).`
`TRANSMEM`	`82 102`	`21`	`3 (Potential).`
`TOPO_DOM`	`103 130`	`28`	`Cytoplasmic (Potential).`
`TRANSMEM`	`131 151`	`21`	`4 (Potential).`
`TOPO_DOM`	`152 163`	`12`	`Extracellular (Potential).`
`TRANSMEM`	`164 184`	`21`	`5 (Potential).`
`TOPO_DOM`	`185 269`	`85`	`Cytoplasmic (Potential).`
`TRANSMEM`	`270 290`	`21`	`6 (Potential).`
`TOPO_DOM`	`291 300`	`10`	`Extracellular (Potential).`
`TRANSMEM`	`301 321`	`21`	`7 (Potential).`
`TOPO_DOM`	`322 357`	`36`	`Cytoplasmic (Potential).`
`CARBOHYD`	`297 297`		`N-linked (GlcNAc...) (Potential).`
`VARIANT`	`350 350`	`1`	`R -> C (in allele VN1R5*3).`	`VAR_022802`
`CONFLICT`	`66 66`		`F -> Y (in Ref. 3; BAB89321).`

Sequence information

Length: 357 AA [This is the length of the unprocessed precursor]

Molecular weight: 40779 Da [This is the MW of the unprocessed precursor]

CRC64: 0E01BA2B43D5F2FE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY PQASFGISAN 

        70         80         90        100        110        120 
TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI LVSLDFFGSQ NTQDDLRYKV 

       130        140        150        160        170        180 
IVFLNKVMRG LSICTPCLLS VLQAIISPSI FSLAKLKHPS ASHILGFFLF SWVLNMFIGV 

       190        200        210        220        230        240 
IFCCTLRLPP VKRGQSSVCH TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD 

       250        260        270        280        290        300 
YFIQTIRGYL SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL 

       310        320        330        340        350 
LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR QCGSTKK

Q7Z5H4 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools