[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. TISSUE=Forebrain; DOI=10.1006/mcpr.2000.0314; PubMed=10970730 [NCBI, ExPASy, EBI, Israel, Japan] Haug K., Kremerskothen J., Hallmann K., Sander T., Dullinger J., Rau B., Beyenburg S., Lentze M.J., Barnekow A., Elger C.E., Propping P., Heils A.; "Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy."; Mol. Cell. Probes 14:255-260(2000).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1093/dnares/3.5.321; PubMed=9039502 [NCBI, ExPASy, EBI, Israel, Japan] Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.; "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."; DNA Res. 3:321-329(1996).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain, and Uterus; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity).
SUBUNIT: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Endosome (By similarity). Acrosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse (By similarity). Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity).
SIMILARITY: Belongs to the ARC/ARG3.1 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF193421; AAF07185.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF248637; AAG33705.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D87468; BAA19667.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012321; AAH12321.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC075802; AAH75802.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_056008.1; -.

UniGene

Hs.40888

3D structure databases

ModBase

Q7LC44.

Organism-specific databases

HGNC:648; ARC.

ARC.

CAB009347; -.

PA24930; -.

Gene expression databases

ArrayExpress

Q7LC44; -.

CleanEx

HS_ARC; -.

Ontologies

GO:0001669;	Cellular component: acrosome (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

BLOCKS

Q7LC44.

Genome annotation databases

Ensembl

ENSG00000198576; Homo sapiens. [Contig view]

GeneID

23237; -.

KEGG

hsa:23237; -.

Phylogenomic databases

HOVERGEN

Q7LC44; -.

Other

ProtoNet

Q7LC44.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell junction; Cell membrane; Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein; Endocytosis; Endosome; Membrane; Postsynaptic cell membrane; Synapse.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 396`	`396`	`Activity-regulated cytoskeleton-associated protein.`	`PRO_0000273285`
`REGION`	`89 100`	`12`	`Binds SH3GL1 or SH3GL3 (By similarity).`
`REGION`	`195 214`	`20`	`Required for binding DNM2 (By similarity).`
`COILED`	`54 78`	`25`	`Potential.`

Sequence information

Length: 396 AA [This is the length of the unprocessed precursor]

Molecular weight: 45316 Da [This is the MW of the unprocessed precursor]

CRC64: D5C8A8A07FE9615D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE 

        70         80         90        100        110        120 
LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF 

       130        140        150        160        170        180 
YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA 

       190        200        210        220        230        240 
GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS 

       250        260        270        280        290        300 
QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ 

       310        320        330        340        350        360 
FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE 

       370        380        390 
QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE

Q7LC44 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools