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UniProtKB/Swiss-Prot entry Q72GU2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ODBB_THET2
Primary accession number Q72GU2
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 28)
Name and origin of the protein
Protein name 2-oxoisovalerate dehydrogenase subunit beta
Synonyms EC 1.2.4.4
Branched-chain alpha-keto acid dehydrogenase E1 component beta chain
BCKDH E1-beta
Gene name
OrderedLocusNames: TT_C1756
From
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [TaxID: 262724] [HAMAP proteome]
Taxonomy Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nbt956; PubMed=15064768 [NCBI, ExPASy, EBI, Israel, Japan]
Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
"The genome sequence of the extreme thermophile Thermus thermophilus.";
Nat. Biotechnol. 22:547-553(2004).
Comments
  • FUNCTION: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
  • CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2.
  • COFACTOR: Thiamine pyrophosphate (By similarity).
  • SUBUNIT: Heterotetramer of two alpha and two beta chains. Directly associated with ODBA in the E1 complex (By similarity).
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017221; AAS82098.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_005725.1; -.
3D structure databases
SMR Q72GU2; 2-324.
ModBase Q72GU2.
Enzyme and pathway databases
BioCyc TTHE262724:TT_C1756-MON; -.
Ontologies
GO
GO:0003863; Molecular function: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR005476; Transketo_C.
IPR005475; Transketo_Cen_R.
IPR015941; Transketolase_C-like.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.920; Transketo_C_like; 1.
Pfam PF02779; Transket_pyr; 1.
PF02780; Transketolase_C; 1.
Pfam graphical view of domain structure.
ProtoNet Q72GU2.
Genome annotation databases
GeneID 2775494; -.
GenomeReviews AE017221_GR; TT_C1756.
Phylogenomic databases
HOGENOM Q72GU2; -.
Genome annotation databases
CMR Q72GU2; TT_C1756.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Oxidoreductase; Thiamine pyrophosphate.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   324  324     2-oxoisovalerate dehydrogenase subunit beta. PRO_0000294976
REGION   58    60  3     Thiamine pyrophosphate (By similarity). 
REGION   83    86  4     Substrate (By similarity). 
REGION   86    89  4     Thiamine pyrophosphate (By similarity). 
ACT_SITE   129   129        Proton acceptor (Probable). 
BINDING   29    29        Thiamine pyrophosphate (By similarity). 
BINDING   82    82        Thiamine pyrophosphate (By similarity). 
BINDING   129   129        Substrate (By similarity). 
Sequence information
Length: 324 AA [This is the length of the unprocessed precursor] Molecular weight: 35083 Da [This is the MW of the unprocessed precursor] CRC64: 6799254F5589D04A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MALMTMVQAL NRALDEEMAK DPRVVVLGED VGKRGGVFLV TEGLLQKYGP DRVMDTPLSE 

        70         80         90        100        110        120 
AAIVGAALGM AAHGLRPVAE IQFADYIFPG FDQLVSQVAK LRYRSGGQFT APLVVRMPSG 

       130        140        150        160        170        180 
GGVRGGHHHS QSPEAHFVHT AGLKVVAVST PYDAKGLLKA AIRDEDPVVF LEPKRLYRSV 

       190        200        210        220        230        240 
KEEVPEEDYT LSIGKAALRR EGKDLTLIGY GTVMPEVLQA AAELAKAGVS AEVLDLRTLM 

       250        260        270        280        290        300 
PWDYEAVMNS VAKTGRVVLV SDAPRHASFV SEVAATIAED LLDMLLAPPI RVTGFDTPYP 

       310        320 
YAQDKLYLPT VTRILNAAKR ALDY
Q72GU2 in FASTA format

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